Patents by Inventor Mu-Yi Hua

Mu-Yi Hua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210063339
    Abstract: A urine testing strip and a urine testing system are provided. The urine testing system includes the urine test strip and a detection device. The urine test strip includes a working electrode, a counter electrode, a reference electrode, a trigger circuit and a protection layer. The protection layer covers the working electrode, the counter electrode and the reference electrode, and portions of the working electrode, the counter electrode and the reference electrode are exposed through an opening of the protection layer. The detection device includes a test strip receiving module and a wireless transmission module. The test strip receiving module is used to receive the test strip and to provide electric power to the test strip for obtaining a detection result. The wireless transmission module is used to transmit the detection result to a mobile computer device.
    Type: Application
    Filed: August 25, 2020
    Publication date: March 4, 2021
    Inventors: Yu-Chia KUO, Ching-Yuan CHEN, Po-Ming YANG, Shun-Wei SHIH, Cho-Wen HUANG, Jen-Chieh CHIEN, Wei-San CHANG, Mu-Yi HUA, Ching-Fu CHEN, Yu-Cheng CHEN, Wan-Tun HUNG, Chin-Lien HUANG
  • Patent number: 10598658
    Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: March 24, 2020
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen
  • Publication number: 20160334399
    Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.
    Type: Application
    Filed: November 16, 2015
    Publication date: November 17, 2016
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen
  • Patent number: 9181290
    Abstract: Disclosed herein are an anti-biofilm composition and a method to inhibit or prevent cell adhesion and/or biofilm formation by a microorganism, in which use of 1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) is involved therein.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: November 10, 2015
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Shih-Tung Liu, Mei-Hui Lin, Fang-Rong Chang, Mu-Yi Hua, Hung-Wei Yang
  • Patent number: 9181167
    Abstract: A chemically-modified graphene includes a graphene layer and a plurality of functional groups that are grafted to the graphene layer and each of which is represented by —CO—R—COOH, wherein R is an optionally substituted C1-C5 alkylene group or an optionally substituted C1-C5 alkenylene group. A method for producing a chemically-modified grapheme includes subjecting a cyclic anhydride and graphite to a Friedel-Crafts reaction in the presence of a Lewis acid.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: November 10, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Shi-Liang Chen, Hsiao-Chien Chen, Rung-Ywan Tsai, Wu-Shiung Feng, Ming-Jer Jeng
  • Patent number: 8992990
    Abstract: The present invention discloses a magnetic nanocomposite for inhibiting/treating cancer and a method for fabricating the same. The magnetic nanocomposite comprises a core formed of a plurality of magnetic nanoparticles made of ferric ferrous oxide (Fe3O4); a shell made of a carboxy-functionalized polyaniline; and an anti-tumor medicine bound to the external surface of the shell. The method of the present invention fast fabricates the magnetic nanocomposite in a simple way. The medicine of the present invention has a longer half life and a better thermal stability. The present invention disperses the water-insoluble medicine in water uniformly to decrease the biological rejection. Moreover, the magnetic nanocomposite of the present invention is guided to the nidus by an external magnetic field to increase the local concentration of the medicine and provide an effective chemotherapy. Therefore, the present invention has competitive advantage over the conventional BCNU.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: March 31, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang
  • Patent number: 8974769
    Abstract: The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: March 10, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Hao-Li Liu
  • Patent number: 8889192
    Abstract: The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: November 18, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Cheng-Keng Chuang, See-Tong Pang, Hao-Li Liu, Rung-Ywan Tsai, Kun-Lung Chuang
  • Patent number: 8858767
    Abstract: This invention is directed to a polyamic acid represented by the following formula (I), and an electrode having an active layer made from the polyamic acid of formula (I).
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: October 14, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Yaw-Terng Chern, Hsiao-Chien Chen, Rung-Ywan Tsai
  • Patent number: 8702924
    Abstract: An electrode for an electrochemical device includes a conductor, and an active layer formed on the conductor and including a polybenzimidazole polymer that contains at least one of the functional group of the following formula:
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: April 22, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Rung-Ywan Tsai, Kong-Wei Cheng
  • Patent number: 8653203
    Abstract: A method for preparing a carboxylic polybenzimidazole includes reacting a polybenzimidazole polymer with a cyclic acid anhydride to form the carboxylic polybenzimidazole.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: February 18, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Rung-Ywan Tsai, Kong-Wei Cheng
  • Patent number: 8653204
    Abstract: A carboxylic polybenzimidazole includes at least one of the following functional group of formula (I): wherein G is a group containing a carboxylic acid end group or a carboxylated end group.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: February 18, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Rung-Ywan Tsai, Lee-Yih Wang
  • Publication number: 20130270112
    Abstract: This invention is directed to a polyamic acid represented by the following formula (I), and an electrode having an active layer made from the polyamic acid of formula (I).
    Type: Application
    Filed: April 12, 2012
    Publication date: October 17, 2013
    Applicant: Chang Gun University
    Inventors: Mu-Yi Hua, Yaw-Terng Chern, Hsiao-Chien Chen, Rung-Ywan Tsai
  • Publication number: 20130251814
    Abstract: The present invention discloses a magnetic nanodrug for treating thrombosis, which comprises a core formed of magnetic nanoparticles, a shell enveloping the core and made of carboxyl-functionalized polyaniline, and a thrombosis-treatment drug covalently bonded to the shell. The magnetic nanodrug of the present invention is non-toxic to vascular endothelial cells, has superior stability, features superparamagnetism, and can be uniformly dissolved in water. Therefore, the magnetic nanodrug for treating thrombosis can be guided by an external magnetic field to concentrate on a specified region and increase the effect of thrombosis treatment.
    Type: Application
    Filed: September 14, 2012
    Publication date: September 26, 2013
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Tony Wu, Rung-Ywan Tsai, Yunn-Hwa Ma, Jyh-Ping Chen
  • Publication number: 20130137894
    Abstract: A chemically-modified graphene includes a graphene layer and a plurality of functional groups that are grafted to the graphene layer and each of which is represented by —CO—R—COOH, wherein R is an optionally substituted C1-C5 alkylene group or an optionally substituted C1-C5 alkenylene group. A method for producing a chemically-modified grapheme includes subjecting a cyclic anhydride and graphite to a Friedel-Crafts reaction in the presence of a Lewis acid.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 30, 2013
    Applicant: Chang Gung University
    Inventors: Mu-Yi Hua, Shi-Liang Chen, Hsiao-Chien Chen, Rung-Ywan Tsai, Wu-Shiung Feng, Ming-Jer Jeng
  • Publication number: 20130011485
    Abstract: The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
    Type: Application
    Filed: July 6, 2011
    Publication date: January 10, 2013
    Applicant: Chang Gung University
    Inventors: Mu-Yi HUA, Hung-Wei Yang, Cheng-Keng Chuang, See-Tong Pang, Hao-Li Liu, Rung-Ywan Tsai, Kun-Lung Chuang
  • Publication number: 20120328705
    Abstract: A magnetic nanomedicine for tumor suppression and therapy, comprising: a core, made of magnetic nanoparticles; a shell, encapsulating said core and is made of carboxylated polyaniline (SPAnH); and a tumor suppression medicine Epirubicin (EPI) or Doxorubicin (DOX) covalently bonded onto said shell. Said magnetic nanomedicine is capable of improving its thermal stability, and it can be dissolved uniformly in water, plus its superparamagnetic property, thus it can be guided by an outside magnetic field to concentrate to the site of tumor distribution to increase the local medicine concentration and enhance therapy effect.
    Type: Application
    Filed: June 22, 2011
    Publication date: December 27, 2012
    Inventors: Mu-Yi Hua, Hong-Wei Yang, Cheng-Keng Chuang, See-Tong Pang, Rung-Ywan Tsai, Kun-Lung Chuang
  • Publication number: 20120321566
    Abstract: Disclosed herein are an anti-biofilm composition and a method to inhibit or prevent cell adhesion and/or biofilm formation by a microorganism, in which use of 1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) is involved therein.
    Type: Application
    Filed: September 19, 2011
    Publication date: December 20, 2012
    Applicant: Chang Gung University
    Inventors: Shih-Tung Liu, Mei-Hui Lin, Fang-Rong Chang, Mu-Yi Hua, Hung-Wei Yang
  • Patent number: 8329222
    Abstract: A magnetic nanomedicine for tumor suppression and therapy, comprising: a core, made of magnetic nanoparticles; a shell, encapsulating said core and is made of carboxylated polyaniline (SPAnH); and a tumor suppression medicine Epirubicin (EPI) or Doxorubicin (DOX) covalently bonded onto said shell. Said magnetic nanomedicine is capable of improving its thermal stability, and it can be dissolved uniformly in water, plus its superparamagnetic property, thus it can be guided by an outside magnetic field to concentrate to the site of tumor distribution to increase the local medicine concentration and enhance therapy effect.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: December 11, 2012
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hong-Wei Yang, Cheng-Keng Chuang, See-Tong Pang, Rung-Ywan Tsai, Kun-Lung Chuang
  • Patent number: 8329064
    Abstract: The present invention provides a water-soluble self-acid-doped polyaniline blends, comprising a 70-90% weight percentage polyaniline derivative and 10-30% weight percentage at least a water-soluble polymer. The blend can be used to produce a conductive polymer film and/or a conductive-polymer composite film. In the present invention, a water-soluble self-acid-doped polyaniline derivative is blended with a water-soluble polymer to enhance the mechanical properties and the coating-to-substrate adhesion of the electric conductive polymer film or the electric conductive-polymer composite film, and increase the conductivity of the blender. In addition, the blend containing a water-soluble self-acid-doped polyaniline of the present invention is biotoxicity-free and has free radical-capture capability. Thus it can be used as a biocompatible and conductive biomedical material.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: December 11, 2012
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hung-Wei Yang, Rung-Ywan Tsai, Ruey-Chi Hsu