Abstract: Biotransformation of an aromatase inhibitor, testolactone (1), yielded four metabolites, 7?-hydroxy-3-oxo-13,17-seco-5?-androsta-1-eno-17,13?-lactone (2), 3?,11?-dihydroxy-13,17-seco-5?-androsta-17,13?-lactone (3), 4?,5?-epoxy-3?-hydroxy-13,17-secoandrosta-1-eno-17,13?-lactone (4), and 4?,5?-epoxy-3?-hydroxy-13,17-secoandrosta-1-eno-17,13?-lactone (5). Aromatase (estrogen synthase) involves in the synthesis of estrogen, and promotes the growth of breast cancerous cells. It is a key target for the discovery of chemotherapeutic agents against ER+(estrogen-positive) breast-cancers. Metabolites 2 (IC50=8.63±0.402 nM), and 3 (IC50=9.23±1.31 nM) were identified as potent inhibitors against human aromatase enzyme, in comparison to 1 (IC50=0.716±0.031 ?M), and the standard aromatase inhibiting drug, exemestane (IC50=0.232±0.031 ?M). Derivatives 4 (IC50=10.37±0.50 ?M) and 5 (IC50=0.82±0.059 ?M) also showed a good inhibition against aromatase enzyme.

Abstract: An information processing apparatus (10) includes a first acquisition unit (111), a second acquisition unit (111), and an estimation unit (112). The first acquisition unit (111) acquires first sensing information obtained by capturing an image of a subject using a first sensor (20A) including a single-plate image sensor. The second acquisition unit (111) acquires second sensing information obtained by sensing a direction different from a direction of the first sensor (20A) using second sensor (20B). The estimation unit (112) estimates the spectral reflectance of the subject based on the first sensing information and the second sensing information.

Abstract: A bag assembly that includes a bag portion having first and second walls defining an interior and an opening. The interior is formed by the first and second walls of the bag portion being attached to each other along at least a portion of a perimeter of the bag assembly up to one end of the bag portion. Portions of the first and second walls of the bag portion that are not attached to each other form the opening. The bag assembly also includes an aseptic system for sterile connection and disconnection of the bag assembly from a sterile process, the aseptic system being continuously formed at an interface between the aseptic system and the one end of the bag portion. The aseptic system includes an internal passage to allow fluid communication with the interior of the bag portion and the sterile process.

Abstract: A method of tracking inventory comprises providing a dispenser. The dispenser includes a body laterally extending between a first end and a second end. The dispenser also includes a stopper slidably coupled to the body to move between the first end and the second end and a biasing member coupled to the stopper to bias the stopper towards the second end. A plurality of identifiers are displayed on the biasing member. The method includes securing a plurality of units within the dispenser between the stopper and the second end, and displaying at least one of the plurality of identifiers to a user of the dispenser, the at least one of the plurality of identifiers corresponding to a total number of units in the dispenser.

Abstract: A method of tracking inventory comprises storing at least one container unit within a dispenser. The dispenser includes a first and second ledge. The dispenser secures at least one container unit within the dispenser using an arm, wherein the arm has a first face. A total container unit distance is determined, wherein the total container unit distance is the distance between the first face and the second ledge. A single container unit distance is identified, wherein the single container unit distance is the change in distance between the first face and the second ledge when a single container unit is removed from the dispenser. A total number of container units in the dispenser is determined, wherein the total number of container units in the dispenser is determined using the total container unit distance by the single container unit distance. The total number of container units in the dispenser is displayed.

Abstract: A video coding apparatus for encoding a compressive sensing signal has a processor. The processor obtains a compressive sensing sampling matrix; and captures the compressive sensing signal representing image data based on the compressive sensing sampling matrix, wherein the compressive sensing sampling matrix is non-uniform varied.

Abstract: A method of tracking inventory comprises storing at least one container unit within a dispenser. The dispenser includes a first and second ledge. The dispenser secures at least one container unit within the dispenser using an arm, wherein the arm has a first face. A total container unit distance is determined, wherein the total container unit distance is the distance between the first face and the second ledge. A single container unit distance is identified, wherein the single container unit distance is the change in distance between the first face and the second ledge when a single container unit is removed from the dispenser. A total number of container units in the dispenser is determined, wherein the total number of container units in the dispenser is determined using the total container unit distance by the single container unit distance. The total number of container units in the dispenser is displayed.

Abstract: A lens unit (120) shows longitudinal chromatic aberration and focuses an imaged scene into a first image for the infrared range in a first focal plane and into a second image for the visible range in a second focal plane. An optical element (150) manipulates the modulation transfer function assigned to the first and second images to extend the depth of field. An image processing unit (200) may amplify a modulation transfer function contrast in the first and second images. A focal shift between the focal planes may be compensated for. While in conventional approaches for RGBIR sensors contemporaneously providing both a conventional and an infrared image of the same scene the infrared image is severely out of focus, the present approach provides extended depth of field imaging to rectify the problem of out-of-focus blur for infrared radiation. An imaging system can be realized without any apochromatic lens.

Abstract: A lens and color filter assembly contains lens units, and each lens unit is assigned to a single-color color filter unit. The lens and color filter assembly may be combined with pixel units such that a plurality of monochromatic, low-resolution images can be obtained, and the monochromatic images refer to shifted versions of the same image object. By a super-resolution technique comprising shift-compensation a mosaicked image is obtained which is then demosaiced. In the resultant image only few artifacts appear. Simple color filter arrays allow a simplified fabrication process and provide less chromatic aberrations at less computational effort.

Abstract: An optical system includes an optical element arranged in an optical path of an optical system. A point spread function of the optical element images out-of-focus object points with positive defocus value into image areas oriented along a first radial axis in an image plane and out-of-focus object points with negative defocus value into image areas oriented along a second radial axis in the image plane. A distance of the image areas to an optical axis of the optical system increases with increasing absolute defocus value.

Abstract: A lens unit of an imaging unit features longitudinal chromatic aberration. From an imaged scene, an imaging sensor unit captures non-color-corrected first images of different spectral content. An intensity processing unit computes broadband luminance sharpness information from the first images on the basis of information descriptive for imaging properties of the lens unit. A chrominance processing unit computes chrominance information on the basis of the first images. A synthesizing unit combines the computed chrominance and luminance information to provide an output image having, for example, extended depth-of-field. The imaging unit may be provided in a camera system, a digital microscope, as examples.

Abstract: A lens and colour filter assembly contains lens units, and each lens unit is assigned to a single-colour colour filter unit. The lens and colour filter assembly may be combined with pixel units such that a plurality of monochromatic, low-resolution images can be obtained, and the monochromatic images refer to shifted versions of the same image object. By a super-resolution technique comprising shift-compensation a mosaicked image is obtained which is then demosaiced. In the resultant image only few artefacts appear. Simple colour filter arrays allow a simplified fabrication process and provide less chromatic aberrations at less computational effort.

Abstract: A lens unit (120) shows longitudinal chromatic aberration and focuses an imaged scene into a first image for the infrared range in a first focal plane and into a second image for the visible range in a second focal plane. An optical element (150) manipulates the modulation transfer function assigned to the first and second images to extend the depth of field. An image processing unit (200) may amplify a modulation transfer function contrast in the first and second images. A focal shift between the focal planes may be compensated for. While in conventional approaches for RGBIR sensors contemporaneously providing both a conventional and an infrared image of the same scene the infrared image is severely out of focus, the present approach provides extended depth of field imaging to rectify the problem of out-of-focus blur for infrared radiation. An imaging system can be realized without any apochromatic lens.

Abstract: A lens and color filter assembly contains lens units, and each lens unit is assigned to a single-color color filter unit. The lens and color filter assembly may be combined with pixel units such that a plurality of monochromatic, low-resolution images can be obtained, and the monochromatic images refer to shifted versions of the same image object. By a super-resolution technique comprising shift-compensation a mosaicked image is obtained which is then demosaiced. In the resultant image only few artifacts appear. Simple color filter arrays allow a simplified fabrication process and provide less chromatic aberrations at less computational effort.

Abstract: A lens unit (120) shows longitudinal chromatic aberration and focuses an imaged scene into a first image for the infrared range in a first focal plane and into a second image for the visible range in a second focal plane. An optical element (150) manipulates the modulation transfer function assigned to the first and second images to extend the depth of field. An image processing unit (200) may amplify a modulation transfer function contrast in the first and second images. A focal shift between the focal planes may be compensated for. While in conventional approaches for RGBIR sensors contemporaneously providing both a conventional and an infrared image of the same scene the infrared image is severely out of focus, the present approach provides extended depth of field imaging to rectify the problem of out-of-focus blur for infrared radiation. An imaging system can be realized without any apochromatic lens.

Abstract: A video coding apparatus for encoding a compressive sensing signal has a processor. The processor obtains a compressive sensing sampling matrix; and captures the compressive sensing signal representing image data based on the compressive sensing sampling matrix, wherein the compressive sensing sampling matrix is non-uniform varied.

Abstract: A method and optical system for determining a depth map of an image, the method including: determining a first focus measure of a first color in at least one region of the image; determining a second focus measure of a second color in the at least one region of the image; determining a ratio of the first and the second focus measure; and determining the depth map based on a ratio of the first and second focus measure.

Abstract: In a method for determining field of view dependent depth map correction values for correction of a depth map of an image taken with a lens having a field of view the following is performed: obtaining (31) relative depth information for at least two different depths and at least two different predetermined locations of the field of view of the lens; receiving (32) an image; determining (33) a depth of the received image; and determining (34) on the basis of the determined depth of the received image at least one depth map correction value on the basis of the relative depth information.

Abstract: An optical system includes an optical element arranged in an optical path of an optical system. A point spread function of the optical element images out-of-focus object points with positive defocus value into image areas oriented along a first radial axis in an image plane and out-of-focus object points with negative defocus value into image areas oriented along a second radial axis in the image plane. A distance of the image areas to an optical axis of the optical system increases with increasing absolute defocus value.

Abstract: A lens and colour filter assembly contains lens units, and each lens unit is assigned to a single-colour colour filter unit. The lens and colour filter assembly may be combined with pixel units such that a plurality of monochromatic, low-resolution images can be obtained, and the monochromatic images refer to shifted versions of the same image object. By a super-resolution technique comprising shift-compensation a mosaicked image is obtained which is then demosaiced. In the resultant image only few artefacts appear. Simple colour filter arrays allow a simplified fabrication process and provide less chromatic aberrations at less computational effort.