Abstract: An aspiration catheter and method of use for inverting the left atrial appendage (LAA) of a patient's heart. The aspiration catheter can include a proximal portion for attachment to a negative pressure source, and a distal portion for making suction contact with the interior wall of the LAA. The distal portion is preferably in the form of a self-expanding suction cup adapted to transition between a collapsed state and an expanded state. The proximal and distal portions share a common internal lumen for transmitting externally applied negative pressure therethrough, and the suction contact created by the negative pressure can adhere the suction cup portion of the catheter to the interior LAA wall for pulling or inverting the LAA into the left atrium.

Abstract: The disclosure features methods of treating RAS protein-related disease using Compound A, or a pharmaceutically acceptable salt thereof. The disclosure also features methods of treating RAS protein-related disease including combinations including Compound A, or a pharmaceutically acceptable salt thereof, and additional therapeutic agents.

Abstract: An aspiration catheter and method of use for inverting the left atrial appendage (LAA) of a patient's heart. The aspiration catheter can include a proximal portion for attachment to a negative pressure source, and a distal portion for making suction contact with the interior wall of the LAA. The distal portion is preferably in the form of a self-expanding suction cup adapted to transition between a collapsed state and an expanded state. The proximal and distal portions share a common internal lumen for transmitting externally applied negative pressure therethrough, and the suction contact created by the negative pressure can adhere the suction cup portion of the catheter to the interior LAA wall for pulling or inverting the LAA into the left atrium.

Abstract: A semiconductor structure comprises a layer of a first III-nitride material having a first lattice dimension; a non-porous layer of a second III-nitride material having a second lattice dimension different from the first lattice dimension; and a porous region of III-nitride material disposed between the layer of first III-nitride material and the non-porous layer of the second III-nitride material. An optoelectronic semiconductor device, an LED, and a method of manufacturing a semiconductor structure are also provided.

Abstract: The invention relates to a device and a method for projecting a plurality of radiation points onto an object surface, comprising at least one radiation source for emitting electromagnetic radiation, comprising at least one beam path, via which the radiation emitted at least temporarily by the emitters is deflected in the direction of the object surface, and comprising a controller which, in order to change at least one property of the emitted radiation, controls the radiation source according to a light object to be generated on the object surface. The controller is designed in such a way that at least two of the plurality of emitters of the radiation source are each individually controlled in order to change at least one property of the emitted radiation according to the light object to be generated, and at least one optical element for shaping, directing and/or converting the electromagnetic radiation is arranged in the beam path.

Abstract: A red-light emitting diode (LED) comprises: an n-doped portion; a p-doped portion; and a light emitting region located between the n-doped portion and a p-doped portion. The light emitting region comprises: a light-emitting indium gallium nitride layer which emits light at a peak wavelength between 600 and 750 nm under electrical bias thereacross; a III-nitride layer located on the light-emitting indium gallium nitride layer; and a III-nitride barrier layer located on the III-nitride layer, and the light emitting diode comprises a porous region of III-nitride material. A red mini LED, a red micro-LED, an array of micro-LEDs, and a method of manufacturing a red LED are also provided.

Abstract: A system can include a mold for performing during a liquid composite molding process. The mold can receive a fiber material comprising a plurality of fibers, at least some fibers coated with MXene to form a fabric sensor. The system can include a sensor system for measuring piezo-resistance of the fabric sensor when the fiber material is mounted in the mold during a molding process of an item in the mold. The system can include a computing device linked to the sensor system. The computing device can include a processor and a memory. The memory can include instructions that are executable by the processor for causing the processor to: responsive to receiving a plurality of measurements of current values associated with the fabric sensor from the sensor system, determining compaction forces associated with the liquid composite molding process.

Abstract: A light emitting diode (LED) comprises: an n-doped portion; a p-doped portion; and a light emitting region located between the n-doped portion and the p-doped portion. The light emitting region comprises: a light-emitting layer which emits light at a peak wavelength between 400 and 599 nm under electrical bias thereacross; a III-nitride layer located on the light-emitting layer; and a III-nitride barrier layer located on the III-nitride layer. The light emitting diode comprises a porous region of III-nitride material. An LED array and a method of manufacturing an LED with a peak emission wavelength between 400 nm and 599 nm under electrical bias are also provided.

Abstract: A liquid crystal device for absorbing and/or scattering a controllable amount of traversing light comprises an active layer having a first viewport surface, a second viewport surface, and at least two side surfaces. The first and second viewport surfaces contact respective first and second planar electrodes. The first and second planar electrodes respectively comprise first and second supply areas for receiving a control voltage for controlling the active layer. A first supply contacting device electrically connects to the first supply area, and a second supply contacting device electrically connects to the second supply area. The supply areas and the supply contacting devices each associate to one or more side surfaces, arranged to extend along at least a part of their respective associated sides, wherein the first supply contacting device and the second supply contacting device associate to adjacent side surfaces.

Abstract: Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived clinical-grade corneal endothelial cells (CECs) generation and cryopreservation through the neural crest cell (NCC) lineage using peripheral blood as a donor source and hESCs maximizes the availability of these vital cells for treating the corneal endothelial disease as an alternative to donor corneas for corneal endothelium (CE) transplantations and other applications.

Abstract: An aspiration catheter and method of use for inverting the left atrial appendage (LAA) of a patient's heart. The aspiration catheter can include a proximal portion for attachment to a negative pressure source, and a distal portion for making suction contact with the interior wall of the LAA. The distal portion is preferably in the form of a self-expanding suction cup adapted to transition between a collapsed state and an expanded state. The proximal and distal portions share a common internal lumen for transmitting externally applied negative pressure therethrough, and the suction contact created by the negative pressure can adhere the suction cup portion of the catheter to the interior LAA wall for pulling or inverting the LAA into the left atrium.

Abstract: In at least one embodiment, the radiation-emitting device comprises a laser bar for emitting laser radiation. The device further includes a waveguide having a core, a cladding, an entry face, and an exit face. The device may include a heat sink having a mounting side where the waveguide is applied thereon, the cladding being arranged at least above and below the core in relation to the mounting side. The device may be configured so that, during operation, the laser radiation impinges on the entry face of the waveguide and passes from there into the core. The core may include a conversion element configured to convert the laser radiation into secondary radiation. The waveguide may be configured to guide the laser radiation and/or the secondary radiation inside the core as far as the exit face by reflection at the interface between the cladding and the core.

Abstract: In an embodiment an edge-emitting laser bar includes an AlInGaN-based semiconductor layer sequence having a contact side and an active layer, a plurality of individual emitters arranged next to each other and spaced apart from one another in a lateral transverse direction, a plurality of contact elements arranged next to each other and spaced apart from one another in the lateral transverse direction on the contact side for making electrical contact with the individual emitters, and a thermal decoupling structure in a region between two adjacent individual emitters, wherein the decoupling structure includes an electrically conductive cooling element located on the contact side and completely covering a contiguous cooling region of the contact side, wherein the cooling element is completely electrically isolated from the semiconductor layer sequence and thermally coupled to the semiconductor layer sequence along the cooling region, and wherein the cooling region has a width, measured along the lateral transver

Abstract: Described herein is aerobic granular sludge gravity-driven membrane system, methods of making and using thereof are described. The aerobic granular sludge (AGS) integrated with a gravity-driven membrane (GDM) filtration system is an energy efficient wastewater treatment system that takes advantage of AGS reactor systems integrated with gravity-driven membrane system to reduce membrane fouling and produce microbiologically and chemically safe water. The AGS-GDM system includes at least an AGS reactor tank containing raw wastewater and granular sludge and a membrane tank including one or more gravity-driven membrane(s).

Abstract: Bioreactors for production and recovery of medium chain carboxylates from organic biomass are disclosed. Methods for improved production and recovery of medium chain carboxylates from organic biomass are also disclosed. The bioreactors can be used as a chain-elongation bioreactor, and a method of use thereof results in improved production and recovery of medium chain carboxylates from organic biomass. The bioreactor includes a shell defined by one or more walls and a length, and a plurality of porous hollow fiber membranes placed inside the reactor for continuous liquid-liquid extraction, as well as granular activated carbon (GAC) as biocarriers. The plurality of hollow fiber membranes is mounted such that a percentage of the length of the shell remains unoccupied by the plurality of porous hollow fiber membranes.

Abstract: Described herein is aerobic granular sludge gravity-driven membrane system, methods of making and using thereof are described. The aerobic granular sludge (AGS) integrated with a gravity-driven membrane (GDM) filtration system is an energy efficient wastewater treatment system that takes advantage of AGS reactor systems integrated with gravity-driven membrane system to reduce membrane fouling and produce microbiologically and chemically safe water. The AGS-GDM system includes at least an AGS reactor tank containing raw wastewater and granular sludge and a membrane tank including one or more gravity-driven membrane(s).

Abstract: Disclosed is an optoelectronic component comprising: an optoelectronic semiconductor chip which generates electromagnetic radiation during operation, and a metallic layer provided on the semiconductor chip, wherein an outer surface of the metallic layer has a patterning, the component can be identified by means of the patterning, and the metallic layer is continuous. Also disclosed is a method for producing an optoelectronic component.

Abstract: The invention provides binding proteins capable of specific binding to a human leukocyte antigen (HLA) complex type A2 presenting a peptide having the amino acid sequence ALYDKTKRI set forth in SEQ ID NO: 1 (peptide T1) or the amino acid sequence ALYDKTKRIFL set forth in SEQ ID NO: 15 (peptide T3) derived from human terminal deoxynucleotidyl transferase (TdT). The binding proteins comprise an antigen binding unit comprising an ?-chain variable domain and a ?-chain variable domain each comprising 3 complementarity determining regions (CDRs) derived from TCRs that recognise the peptides. The binding proteins and cells expressing them, may be used in cancer therapy.

Abstract: A variable-wavelength light emitting diode (LED) is provided. The variable-wavelength LED comprises an n-doped portion, a p-doped portion, and a light-emitting region located between the n-doped portion and the p-doped portion. The light-emitting region comprises a light-emitting layer which emits light at a peak emission wavelength under electrical bias thereacross. The LED is configured to receive a power supply, and the peak emission wavelength of the LED is continuously controllable over an emission wavelength range of at least 40 nm by varying the power supply. A display device comprising this variable-wavelength LED, a method of controlling said variable-wavelength LED and a method of manufacturing a variable-wavelength LED are also provided.

Abstract: A liquid crystal device for absorbing and/or scattering a controllable amount of traversing light comprises an active layer having a first viewport surface, a second viewport surface, and at least two side surfaces. The first and second viewport surfaces contact respective first and second planar electrodes. The first and second planar electrodes respectively comprise first and second supply areas for receiving a control voltage for controlling the active layer. A first supply contacting device electrically connects to the first supply area, and a second supply contacting device electrically connects to the second supply area. The supply areas and the supply contacting devices each associate to one or more side surfaces, arranged to extend along at least a part of their respective associated sides, wherein the first supply contacting device and the second supply contacting device associate to adjacent side surfaces.