Abstract: The disclosure describes methods and compositions for reducing the level or activity of metabotropic glutamate receptor 5 (mGluR5) or/and cannabinoid receptor 1 (CB1R) for the treatment of fibrotic disorders such as pulmonary fibrotic disorders (e.g., fibrosing interstitial lung discases). In some embodiments, a mGluR5 antagonist or/and a CB1R antagonist (c.g., a peripheral CB1R antagonist) is/are used to treat a fibrotic disorder such as a pulmonary fibrotic disorder (e.g., a fibrosing interstitial lung disease).

Abstract: A method and a system of distributed estimation using q-diffusion least mean squares (qDiff-LMS) to modify adaptive filter weights in a decentralized wireless sensor network of N nodes is described. The method includes receiving, at each node, k, a local estimate of a previous time instance weight, wk(i?1), of an adaptive filter of each neighboring node, l, where l=1, 2, . . . , M, combining the local estimates of the previous time instance weights to generate a linear combination of global diffused weights, Øk(i?1), measuring, for each node k, an output, yk(i), of the adaptive filter of the node k, calculating, for each node k, a desired response, dk(i); generating, for each node k, an estimation error, ekCTA(i) by subtracting the output, yk(i) from the desired response, dk(i), and updating the global diffused weights by adding a portion of the estimated error to the global diffused weights.

Abstract: A computer system can detect a request for status information relating to a particular deployment pattern; query, in response to the request, a deployment pattern registry for deployment configuration information about the particular deployment pattern; test deployment capabilities for the particular deployment pattern by: verifying installation files for the particular deployment pattern are accessible; identifying one or more candidate deployment components for a hypothetical deployment of the particular deployment pattern; installing, on the one or more candidate deployment components, a virtual machine that is configured to test computing resources of the one or more candidate deployment components; and receiving test results regarding the resources of the one or more candidate deployment components. The system can generate a notification in response to detecting a failure in the testing.

Abstract: A system, apparatus, method, and computer program product are provided that receive first input via a console to configure a plurality of different combinations of performance parameters that correspond to a manner in which a service may be provided, wherein the console is configured to provide a plurality of other services. The system, apparatus, method, and computer program also publish a plurality of user-facing interfaces to a service request catalog as a plurality of different service offerings, wherein the plurality of different service offerings correspond to the plurality of different combinations of performance parameters for the service. Further, the system, apparatus, method, and computer program initiate the service in a manner that corresponds to one of the plurality of different combinations of performance parameters for one of the plurality of service offerings when that one of the plurality of service offerings is selected with second input received via the console.

Abstract: A coach decision support method including collecting sensor data associated with an athlete at a data logger circuitry; wherein sensor data is generated by at least one sensor placed on the athlete; pre-processing the sensor data at the data logger circuitry and filtering sensor noise from the collected sensor data; extracting at least one feature of the collected sensor data; classifying the at least one extracted feature into at least one physical activity; transmitting the physical activity classification to a data analysis module; generating a detailed report of the physical activity analyzing the athlete's performance within a sporting arena; and generating at least one coach decision recommendation based at least in part on the generated detailed report.

Abstract: A spinal cord posture monitoring system for monitoring posture conformities of a spinal cord includes a wearable measurement device that houses a plurality of sensors, at least one mechanical assembly segment, the mechanical assembly segment includes a spherical encoder, a connector link connected to the spherical encoder on one end and to a hollow tube on the opposite end, such that the hollow tube is connected to the connector link on one end. The system also includes a communication circuit to communicate sensor information to a mobile application on a mobile device.

Abstract: A comfort level monitoring system monitors the physical and surrounding environment of an individual includes a wearable item to house a plurality of sensors, at least one physical pressure measuring sensor to detect an amount of external physical pressure exerted on a person wearing the wearable item, a first set of sensors to detect environmental data associated with an environmental comfort level of the person wearing the wearable item, a second set of sensors to detect oxygen ratios associated with the environment surrounding the person, a third set of sensors to detect total energy expenditure of the person, a user interface to receive personal physical data associated with the person, a fuzzy logic circuit to calculate, in response to received inputs, an overall comfort level associated with the person, and an activity alarm triggered when the overall comfort level falls below a predetermined threshold.

Abstract: A computer system can detect a request for status information relating to a particular deployment pattern; query, in response to the request, a deployment pattern registry for deployment configuration information about the particular deployment pattern; test deployment capabilities for the particular deployment pattern by: verifying installation files for the particular deployment pattern are accessible; identifying one or more candidate deployment components for a hypothetical deployment of the particular deployment pattern; installing, on the one or more candidate deployment components, a virtual machine that is configured to test computing resources of the one or more candidate deployment components; and receiving test results regarding the resources of the one or more candidate deployment components. The system can generate a notification in response to detecting a failure in the testing.

Abstract: A controlled food intake system includes an apparatus having an inlet tube configured to connect to a lower esophageal stoma, a flow controller, and at least one container configured to detachably attach to the inlet tube and to administer nutrition liquids to a patient at a flow rate based on a position of the flow controller. The apparatus also includes an outlet tube configured to connect to an upper esophageal stoma and a waste container that detachably attaches to the outlet tube. Processing circuitry of the apparatus is configured to control the flow controller to control the flow rate of the nutrition liquids being administered to the patient based on prescribed nutrition intake order. The controlled food intake system also includes at least one server configured to generate reports based on the nutrition liquids administered to the patient and substance consumed by the patient.

Abstract: A coach decision support method including collecting sensor data associated with an athlete at a data logger circuitry; wherein sensor data is generated by at least one sensor placed on the athlete; pre-processing the sensor data at the data logger circuitry and filtering sensor noise from the collected sensor data; extracting at least one feature of the collected sensor data; classifying the at least one extracted feature into at least one physical activity; transmitting the physical activity classification to a data analysis module; generating a detailed report of the physical activity analyzing the athlete's performance within a sporting arena; and generating at least one coach decision recommendation based at least in part on the generated detailed report.

Abstract: A computer system can detect a request for status information relating to a particular deployment pattern; query, in response to the request, a deployment pattern registry for deployment configuration information about the particular deployment pattern; test deployment capabilities for the particular deployment pattern by: verifying installation files for the particular deployment pattern are accessible; identifying one or more candidate deployment components for a hypothetical deployment of the particular deployment pattern; installing, on the one or more candidate deployment components, a virtual machine that is configured to test computing resources of the one or more candidate deployment components; and deleting the virtual machine in response to receiving test results regarding the resources of the one or more candidate deployment components. The system can generate a notification in response to detecting a failure in the testing.

Abstract: A computer system can detect a request for status information relating to a particular deployment pattern; query, in response to the request, a deployment pattern registry for deployment configuration information about the particular deployment pattern; test deployment capabilities for the particular deployment pattern by: verifying installation files for the particular deployment pattern are accessible; identifying one or more candidate deployment components for a hypothetical deployment of the particular deployment pattern; installing, on the one or more candidate deployment components, a virtual machine that is configured to test computing resources of the one or more candidate deployment components; and deleting the virtual machine in response to receiving test results regarding the resources of the one or more candidate deployment components. The system can generate a notification in response to detecting a failure in the testing.

Abstract: A set of computing devices are networked together. Each device maintains data about the other computing devices in the set, namely, a time and location of a last successful connection between the device and one or more of the other devices. The data at a device is updated as computing devices in the set move out of communication range with one another, for example (a) when the particular computing device itself loses contact with one of the other computing devices in the set, or (b) when the particular computing device receives a notification from one of the other computing devices that such other computing device has lost contact with a computing device that the other computing device had been in contact with. The connection table data is then used to locate a lost computing device, or the identity of a device that has such information in its connection table.

Abstract: A computer system can detect a request for status information relating to a particular deployment pattern; query, in response to the request, a deployment pattern registry for deployment configuration information about the particular deployment pattern; test deployment capabilities for the particular deployment pattern by: verifying installation files for the particular deployment pattern are accessible; identifying one or more candidate deployment components for a hypothetical deployment of the particular deployment pattern; installing, on the one or more candidate deployment components, a virtual machine that is configured to test computing resources of the one or more candidate deployment components; and deleting the virtual machine in response to receiving test results regarding the resources of the one or more candidate deployment components. The system can generate a notification in response to detecting a failure in the testing.

Abstract: A patterning device, including alignment targets having alignment features formed from a plurality of diffractive elements, each diffractive element including an absorber stack and a multi-layered reflector stack is provided. The diffractive elements are configured to enhance a pre-determined diffraction order used for pre-alignment and to diffract light in a pre-determined direction of a pre-alignment system when illuminated with light of a wavelength used for the pre-alignment. The diffractive elements may occupy at least half of an area of each alignment feature. The diffractive elements may be configured to enhance first or higher order diffractions, while substantially reducing zeroth diffraction orders and specular reflection when illuminated with a wavelength used for reticle prealignment. The dimensions of each diffractive element may be a function of a diffraction grating period of each alignment feature.

Abstract: A system for equalizing pulse to pulse energy of a light beam includes a group of optical devices including an optical device configured to exhibit nonlinear properties, e.g., higher order or third order nonlinear properties. Transmission properties of an unequalized light beam passing through the group of optical devices change such that an output intensity of a resulting light beam output from the optical devices is equalized. One example configuration includes at least first and second prisms having nonlinear properties, i.e., higher order or third order, and configured as a beam steering system.

Abstract: A system for equalizing pulse to pulse energy of a light beam includes a group of optical devices including an optical device configured to exhibit nonlinear properties, e.g., higher order or third order nonlinear properties. Transmission properties of an unequalized light beam passing through the group of optical devices change such that an output intensity of a resulting light beam output from the optical devices is equalized. One example configuration includes at least first and second prisms having nonlinear properties, i.e., higher order or third order, and configured as a beam steering system.

Abstract: A system for equalizing pulse to pulse energy of a light beam includes a group of optical devices including an optical device configured to exhibit third order nonlinear properties. Transmission properties of an unequalized light beam passing through the group of optical devices change such that an output intensity of a resulting light beam output from the optical devices is equalized. One example configuration includes a beam splitter, a nonlinear interference filter, a mirror and a beam combiner. A first portion of the light beam that is reflected from the nonlinear interference filter is combined with the light beam such that a resulting combined light beam has equalized output intensity. Another example includes at least first and second prisms having third order nonlinear properties and configured as a beam steering system. A lithography system and a method of equalizing pulse to pulse energy in a light beam are also presented.

Abstract: A system for equalizing pulse to pulse energy of a light beam includes a group of optical devices including an optical device configured to exhibit third order nonlinear properties. Transmission properties of an unequalized light beam passing through the group of optical devices change such that an output intensity of a resulting light beam output from the optical devices is equalized. One example configuration includes a beam splitter, a nonlinear interference filter, a mirror and a beam combiner. A first portion of the light beam that is reflected from the nonlinear interference filter is combined with the light beam such that a resulting combined light beam has equalized output intensity. Another example includes at least first and second prisms having third order nonlinear properties and configured as a beam steering system. A lithography system and a method of equalizing pulse to pulse energy in a light beam are also presented.

Abstract: A device package and method of fabrication where an optical fiber is aligned with an optical device, such as a laser or photodetector. An alignment assembly is provided which includes a ring and a barrel slidably mounted within an aperture in the ring. The ring is placed on a wall of the housing, and the barrel, which includes the fiber, is inserted in the ring. The barrel and/or the ring is moved until the desired position of the fiber is obtained, at which time the ring is fixed to the wall and to the barrel.