Patents by Inventor Muhammad Monim-ul-Mehboob

Muhammad Monim-ul-Mehboob has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gold(I) complexes with anticancer properties and methods of use thereof
    Patent number: 10092579
    Abstract: Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: October 9, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Muhammad Altaf, Muhammad Monim-Ul-Mehboob, Anvarhusein Abdulkadir Isab, Saleh Altuwaijri
  • GOLD(I) COMPLEXES WITH ANTICANCER PROPERTIES AND METHODS OF USE THEREOF
    Publication number: 20170232012
    Abstract: Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 17, 2017
    Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Muhammad ALTAF, Muhammad MONIM-UL-MEHBOOB, Anvarhusein Abdulkadir ISAB, Saleh ALTUWAIJRI
  • GOLD(I) COMPLEXES WITH ANTICANCER PROPERTIES AND METHODS OF USE THEREOF
    Publication number: 20170197997
    Abstract: Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
    Type: Application
    Filed: January 7, 2016
    Publication date: July 13, 2017
    Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Muhammad ALTAF, Muhammad MONIM-UL-MEHBOOB, Anvarhusein Abdulkadir ISAB, Saleh ALTUWAIJRI
  • PLATINUM COMPLEXES AS ANTICANCER AGENTS
    Publication number: 20170136031
    Abstract: Novel compounds comprising a Pt(II) metal center and S-containing ligands as anticancer agents including tetrakis(1,3-diazinane-2-thione)platinum(II) chloride monohydrate complex [Pt(Diaz)4]Cl2.H2O, wherein Diaz=1,3-diazinane-2-thione. Cytotoxic evaluations reveal that the compound possesses better cytotoxic activities against MCF7 than cisplatin. Methods of treating cancer comprising administering the compound are also provided.
    Type: Application
    Filed: January 27, 2017
    Publication date: May 18, 2017
    Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Ahmed Zainelabdeen Abdalla Mustafa, Muhammad Monim-Ul-Mehboob, Muhammad Altaf, Anvarhusein Isab
  • Treatment of cervical cancer with gold(I) complexes
    Patent number: 9572822
    Abstract: Gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 21, 2017
    Assignees: King Fahd University of Petroleum and Minerals, King Abdulaziz City for Science and Technology
    Inventors: Anvarhusein Abdulkadir Isab, Muhammad Altaf, Muhammad Monim-Ul-Mehboob, Adam Ahmed Abdallah Seliman, Mohammed Ismail Wazeer
  • TREATMENT OF CERVICAL CANCER WITH GOLD(I) COMPLEXES
    Publication number: 20170020901
    Abstract: Gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.
    Type: Application
    Filed: September 30, 2016
    Publication date: January 26, 2017
    Applicants: KING FAHD UNIVERSITY OF PETROLEUM AND MATERIALS, KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY
    Inventors: Anvarhusein AbdulKadir ISAB, Muhammad ALTAF, Muhammad MONIM-UL-MEHBOOB, Adam Ahmed Abdallah SELIMAN, Mohammed Ismail WAZEER
  • Gold(I) complexes with t-butyl phosphine and dialkyl dithiocarbamate ligands
    Patent number: 9492465
    Abstract: Gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: November 15, 2016
    Assignees: King Fahd University of Petroleum and Minerals, King Abdulaziz City for Science and Technology
    Inventors: Anvarhusein Abdulkadir Isab, Muhammad Altaf, Muhammad Monim-Ul-Mehboob, Adam Ahmed Abdallah Seliman, Mohammed Ismail Wazeer
  • GOLD(I) COMPLEXES WITH T-BUTYL PHOSPHINE AND DIALKYL DITHIOCARBAMATE LIGANDS
    Publication number: 20160193236
    Abstract: Gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.
    Type: Application
    Filed: February 12, 2016
    Publication date: July 7, 2016
    Applicants: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS, KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY
    Inventors: Anvarhusein Abdulkadir ISAB, Muhammad Altaf, Muhammad Monim-Ul-Mehboob, Adam Ahmed Abdallah Seliman, Mohammed Ismail Wazeer
  • PLATINUM COMPLEXES AS ANTICANCER AGENTS
    Publication number: 20160130291
    Abstract: Compounds comprising a Pt(II) metal center and S-containing ligands in accordance to Formula I as anticancer agents. Methods of treating cancer comprising administering the compounds are also provided.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 12, 2016
    Applicant: King Fahd University of Petroleum and Minerals
    Inventors: Ahmed Zainelabdeen Abdalla Mustafa, Muhammad Monim-Ul-Mehboob, Muhammad Altaf, Anvarhusein Abdulkadir Isab
  • GOLD(I) COMPLEXES WITH T-BUTYL PHOSPHINE AND DIALKYL DITHIOCARBAMATE LIGANDS
    Publication number: 20150266909
    Abstract: Gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 24, 2015
    Applicants: King Abdulaziz City for Science and Technology, King Fahd University of Petroleum and Minerals
    Inventors: Anvarhusein Abdulkadir Isab, Muhammad Altaf, Muhammad Monim-ul-Mehboob, Adam Ahmed Abdallah Seliman, Mohammed Ismail Wazeer