Abstract: A multi-analyte sensor system is provided, comprising: a transmitter for containing a battery the transmitter being for placement on top of patient skin; and an implantable multianalyte monolithic integrated circuit for placement beneath the patient skin, wherein the implantable multianalyte monolithic integrated circuit comprises a sensor control circuit (e.g., Potentiostat, Voltametric Circuit) and an electrochemical sensing element, wherein the electrochemical sensing element is configured to sense concentrations of two or more analytes and generate an electrical signal representative of these concentrations, and wherein sensor control circuit is electrically connected to the electrochemical sensing element and enables independent control of detection method and conditions (e.g., redox potential) at the integrated sensing circuit.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (I) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (I) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (1) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (1) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (I) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

Abstract: A prosthetic valve comprises a frame assembly having a first opening at an inflow portion of the frame assembly and a second opening at an outflow portion of the frame assembly, a first sensor device situated at the inflow portion of the frame, and a second sensor device situated at the outflow portion of the frame. Each of the first sensor device and the second sensor device is configured to sense a physical parameter and provide a sensor signal. The prosthetic valve further comprises a transmitter assembly configured to receive the sensor signals from the first sensor device and the second sensor device and wirelessly transmit a transmission signal based at least in part on the sensor signals.

Abstract: Disclosed is a finger cuff connectable to a patient's finger to be used in measuring the patient's blood pressure utilizing the volume clamp method. The finger cuff may comprise: a finger cavity to receive the patient's finger; a micro-laser and a detector to measure a pleth signal; a bladder mountable within the finger cavity, wherein the patient's finger received in the finger cavity abuts against the bladder; and a processor. The processor may be configured to control pressure applied by the bladder to the patient's finger based upon measuring the pleth signal received from the detector and the micro-laser to keep the pleth signal approximately constant to replicate the patient's blood pressure to implement the volume clamp method and to measure the patient's blood pressure.

Abstract: Disclosed is a non-invasive tissue oximetry device that is attachable to a patient's tissue to measure oxygen perfusion of the patient's tissue. The non-invasive tissue oximetry device includes: one or more micro-lasers to generate one or more optical signals; one or more detectors to receive the one or more optical signals; and a processor coupled to the one or more micro-lasers and detectors to measure oxygen perfusion of the tissue based upon the received one or more optical signals.

Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: Monitoring of one or more key indicators can provide powerful insights into operation and state of different physical systems. For example, continuous monitoring of multiple analyte in body will allow for detailed insights into personal health and will allow for preventative health management. In this application, we present an ultra-small scale wireless sensing platform capable of long-term wireless in-vivo sensing. The key for extreme miniaturization lies in ultra-low-power compact design and lithographic integration of key system components. The key to low cost is using standard technologies and scalable manufacturing. For example, using standard semiconductor technologies for sensing, processing and wireless operation paves way to a low-cost integrated wireless sensing technology. Modern semiconductor technologies provide the capability to provide low-power and yet powerful electronics functionality in a small (mm-scale) size and wireless operation at high frequency.

Abstract: Respiratory diseases affect a large part of world population, especially in developing world. In this invention, we present a breathing support system to provide life-saving support to such patients. The system automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system uses mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia). The system can be used to save hundreds of thousands of lives in the developing world, in emergencies and during transportation globally.

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

Abstract: Respiratory diseases affect a large part of world population, especially in developing world. In this invention, we present a breathing support system to provide life-saving support to such patients. The system automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system uses mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia). The system can be used to save hundreds of thousands of lives in the developing world, in emergencies and during transportation globally.

Abstract: Respiratory diseases affect a large part of world population, especially in developing world. In this invention, we present a breathing support system to provide life-saving support to such patients. The system automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system uses mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia). The system can be used to save hundreds of thousands of lives in the developing world, in emergencies and during transportation globally.

Abstract: Respiratory diseases affect a large part of world population, especially in developing world. In this invention, we present a breathing support system to provide life-saving support to such patients. The system automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system uses mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia). The system can be used to save hundreds of thousands of lives in the developing world, in emergencies and during transportation globally.

Abstract: In this disclosure, a breathing support system is presented which automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system can use mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia).

Abstract: A sensing device allows detection of biological quantities in ways that are minimally invasive. Micrometer or nanometer sized needles allow sensing of bodily fluids in a minimally invasive method. The device comprises electronics and power harvesting. Antennas or coils allow communication and power harvesting from an external device, which can be attached to smartphones to allow operation of a camera and camera light for biosensing.