Patents by Inventor Muhammad Sharaf

Muhammad Sharaf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8637247
    Abstract: The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: January 28, 2014
    Assignee: Applied Biosystems, LLC
    Inventors: Muhammad Sharaf, Timothy Woudenberg, Khairuzzaman Bashar Mullah
  • Publication number: 20070249001
    Abstract: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in a sample, the methods employing employ single molecule detection techniques to individually detect at least one molecular complex or at least part of a molecular complex.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 25, 2007
    Applicant: Applera Corporation
    Inventors: Timothy Woudenberg, Dar Bahatt, Muhammad Sharaf, Timothy Liu, Serguei Ermakov, Charles Connell, Jens Hyldig-Nielsen
  • Publication number: 20060102479
    Abstract: The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards and their use. A multiple color calibration standard is a mixture of at least two polynucleotides of different length, wherein each of the polynucleotides is labeled with a spectrally distinct fluorescent dye. Another aspect of the invention is to produce total emission temporal profiles of multiple color calibration standards for use in calibrating fluorescent polynucleotide separation apparatus. The peaks corresponding to the fluorescently labeled polynucleotides in the total emission temporal profile may be detected using a peak detector that is driven by changes in the slopes of the total emission temporal profile.
    Type: Application
    Filed: December 30, 2005
    Publication date: May 18, 2006
    Applicant: Applera Corporation
    Inventors: Muhammad Sharaf, Maria Roque-Biewer
  • Publication number: 20050074774
    Abstract: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in a sample, the methods employing employ single molecule detection techniques to individually detect at least one molecular complex or at least part of a molecular complex.
    Type: Application
    Filed: August 29, 2003
    Publication date: April 7, 2005
    Applicant: Applera Corporation
    Inventors: Timothy Woudenberg, Dar Bahatt, Muhammad Sharaf, Timothy Liu, Serguei Ermakov, Charles Connell, Jens Hyldig-Nielsen
  • Publication number: 20050069895
    Abstract: The teachings herein generally relates to probes comprising fabricated coded molecular tags for detecting analytes. The teachings also relate to compositions, methods, and kits for fabricating coded molecular tags comprising a multiplicity or reporter groups in an ordered pattern.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 31, 2005
    Applicant: Applera Corporation
    Inventors: Timothy Woudenberg, Dar Bahatt, Muhammad Sharaf, Timothy Liu, Serguei Ermakov, Charles Connell, Jens Hyldig-Nielsen, Benjamin Schroeder, Paolo Vatta
  • Publication number: 20050048498
    Abstract: The present teachings generally relate to probes and probes sets for detecting analytes. The teachings also relates to compositions, methods, and kits for assembling probes comprising at least one coded molecular tag.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 3, 2005
    Applicant: Applera Corporation
    Inventors: Timothy Woudenberg, Dar Bahatt, Muhammad Sharaf, Timothy Liu, Serguei Ermakov, Charles Connell