Patents by Inventor Muhsen Al-Dhalimy

Muhsen Al-Dhalimy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of expanding human hepatocytes in vivo
    Patent number: 8569573
    Abstract: Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, allowing the hepatocytes to expand and collecting the expanded human hepatocytes. The method also allows serial transplantation of the human hepatocytes into secondary, tertiary, quaternary or additional mice. Also provided are mutant mice comprising homozygous deletions or point mutations in the Fah, Rag2 and Il2rg genes.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: October 29, 2013
    Assignees: Oregon Health & Science University, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Markus Grompe, Hisaya Azuma, Muhsen Al-Dhalimy, Mark A. Kay
  • METHOD OF EXPANDING HUMAN HEPATOCYTES IN VIVO
    Publication number: 20100325747
    Abstract: Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, allowing the hepatocytes to expand and collecting the expanded human hepatocytes. The method also allows serial transplantation of the human hepatocytes into secondary, tertiary, quaternary or additional mice. Also provided are mutant mice comprising homozygous deletions or point mutations in the Fah, Rag2 and Il2rg genes.
    Type: Application
    Filed: June 5, 2008
    Publication date: December 23, 2010
    Inventors: Markus Grompe, Hisaya Azuma, Muhsen Al-Dhalimy, Mark A. Kay