Abstract: A method of treating cardiac hypertrophy and/or heart failure in a subject includes administering to the subject a therapeutically effective amount of a REV-ERB? agonist.

Abstract: A method of treating cardiac hypertrophy and/or heart failure in a subject includes administering to the subject a therapeutically effective amount of a REV-ERB? agonist.

Abstract: A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film; providing sheet metal having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.

Abstract: A method of treating cardiac hypertrophy and/or heart failure in a subject includes administering to the subject a therapeutically effective amount of a REV-ERB? agonist.

Abstract: A method of treating a cardiomyopathy in a subject in need thereof includes administering to the subject a therapeutically amount of a CCR2 inhibitor.

Abstract: A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film; providing sheet metal having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.

Abstract: A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film (24); providing sheet metal (26) having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate (22) comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.

Abstract: A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film (24); providing sheet metal (26) having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate (22) comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.

Abstract: A stretchable chemical protective material is described comprising a selectively permeable chemical protective film and an elastic textile. Further described are methods for making a stretchable chemical protective material and methods of using the same. Materials made from these methods may have improved flex durability. Garments made from these materials may have improved heat loss.

Abstract: A stretchable chemical protective material is described comprising a selectively permeable chemical protective film and an elastic textile. Further described are methods for making a stretchable chemical protective material and methods of using the same. Materials made from these methods may have improved flex durability. Garments made from these materials may have improved heat loss.

Abstract: A protective covering is described comprising at least one microporous film attached to a functional layer, the protective covering capable of inhibiting the passage of toxic substances therethrough. Preferably the functional layer is an adsorptive layer contained between two oleophobic, microporous films. Additional shell and backer layers may be added to the construction forming a protective covering having good durability, flexibility and high moisture vapor transmission.

Abstract: The present invention is directed to protective coverings, such as articles of apparel and enclosures, capable of transmitting high amounts of moisture vapor and resisting permeation to noxious chemicals. Preferred chemical protective coverings comprise a fabric laminate comprising at least one layer of apparel fabric and a layer comprising a sulfonated aromatic polymer. The present invention is further directed to a method of reducing exposure of a person to harmful chemicals.

Abstract: A process for producing fibres composed of or coated with carbides or nitrides. The process involves forming a first reaction zone containing microfine particles of an oxide (or oxide precursor) of silicon or a suitable metal (e.g. boron) uniformly mixed with carbon (or a carbon precursor); forming a second reaction zone comprising a layer having a thickness of 1 cm or less of a porous mass having a density of 1 g/cc or less formed of short or continuous fibres made of or coated with carbon (or carbon precursor); heating the first reaction zone in a non-oxidizing atmosphere to generate a gaseous sub-oxide of the silicon or metal; simultaneously heating the second reaction zone so that the gaseous sub-oxide diffuses into it and reacts with the carbon to form carbide or nitride on the fibres; and separating the resulting fibres from any carbide or nitride whiskers that may have formed in the second rection zone. Short or continuous fibres (e.g.

Abstract: A process of producing nitrides of aluminum and titanium. The process involves producing a uniform dispersion of microfine particles of the corresponding metal oxide in an infusible polymer, carbonizing the resulting dispersion in a non-oxidizing atmosphere and heating the carbonized product in a nitrogen atmosphere at high temperature to cause the oxide to react with the carbon and nitrogen to form the nitride. Before carbonization, however, the dispersion is formed into shapes in which none of the oxide particles is more than about 2.5 mm (0.098 inch) from an external surface and the shapes are loosely packed in a reactor. The process can achieve a good conversion of the oxide to the nitride to yield a product of high purity and small particle size.

Abstract: A process for producing silicon carbide platelets and the platelets so produced. The process comprises reacting particles of a non-graphitizable form of hard carbon containing 0.5-1.5% by weight of aluminum and at least 0.2% by weight of iron (preferably anthracite coal, most preferably Pennsylvania anthracite), with silica or a silica precursor at a temperature in the range of 1900.degree.-2100.degree. C. under an inert atmosphere. If the carbon contains 0.2-1.0% by weight of iron, 0.1-10% by weight of boron, relative to the weight of SiO.sub.2, is added (if not already present). The carbon is in the form of particles of less than 50.mu. and the silica or precursor is preferably in the form of particles of less than about 1 .mu.. The weight ratio of silica to carbon is greater than 1.67:1. The resulting platelets are substantially unagglomerated and preferably of a size of less than 50.mu. with an aspect ratio greater than 5. The platelets can be used as reinforcements for ceramic and metal matrix materials.

Abstract: Shaped refractory products, particularly in the form of hollow spheres, and a process for their formation. The process involves dispersing particles of silica or a metal oxide, e.g. Al.sub.2 O.sub.3, in an organic polymer, shaping the dispersion into a desired shape, heating the shaped dispersion in a non-oxidizing atmosphere to carbonize the polymer, and heating the carbonized product at high temperature in a non-oxidizing atmosphere containing nitrogen so that some of the oxide is converted to the corresponding nitride and the particles of unreacted oxide sinter together. The ratio of oxide to carbon should be high so that some but not all of the oxide is converted to the nitride and, preferably, only a relatively small amount should be converted. The resulting refractory material is strong and can be used for a variety of uses, e.g. catalyst supports, packing materials and insulating materials.

Abstract: A process for forming silicon nitride containing little or no silicon carbide. The process involves producing a uniform dispersion of finely divided silica particles in a polymer, heating the polymer/silica dispersion in a non-oxidizing atmosphere to carbonize the polymer, and heating the resulting carbonized product to a temperature in the range of 1300.degree.-1800.degree. C. in a non-oxidizing nitrogen-containing atmosphere. This latter heating step is carried out in the presence of a metal oxide (preferably alumina which is capable, in the reaction conditions, of reducing the amount of silicon carbide formed as an undesired by-product.

Abstract: Porous membranes made of sintered refractory metal oxides, e.g., silica aluimina, titania, zirconia, tungsten oxide, etc., and to a process for their formation. The membranes are formed by dispersing a powder of the metal oxide in an organic polymer. The relative amount of metal oxide to polymer is such that, after the polymer has been carbonized in a subsquent step, there is a stoichiometrical excess of the oxide to carbon. The solution is then shaped to form a desired thin membrane, and the polymer is then carbonized by heating it in a non-oxidizing atmosphere. The resulting oxide/carbon product is heated to a temperature at which (a) the carbon reacts with the oxide to form a volatile sub-oxide and carbon monoxide and (b) the remaining (unreacted) oxide particles sinter together. The heating is carried out in a non-oxidizing atmosphere containing either no nitrogen whatsoever, or an amount of nitrogen less than that which results in the formation of a non-porous product.

Abstract: A method of producing whiskers of silicon carbide and other materials. For the formation of silicon carbide, the method involves forming a first reaction zone containing microfine particles of silicon dioxide uniformly mixed with carbon or a carbon precursor, with the ratio of the silicon dioxide to the carbon present as a starting material or derivable from the precursor being greater than about 5 to 1 by weight. A closely adjacent second reaction zone is formed containing a porous fibrous mass of active carbon or an infusible carbon precursor. The reaction zones are heated under a non-oxidizing atmosphere to temperatures at which silicon monoxide is formed in the first reaction zone, diffuses to the second reaction zone and reacts with carbon derived from the carbon precursor in the second reaction zone to form silicon carbide whiskers.