Abstract: The present invention describes an orally administered edible product designed to provide a health benefit in a delivery formulation that will increase ease of use and thus lead to increased compliance and consumption to promote human health and wellness. The present invention provides an enhanced oral delivery method by developing edible products that can be ingested like food, are designed to taste like food not medicine, provide optimal absorption of lipophilic ingredients and allow for the delivery of the equivalent of multiple capsules in a single oral “dose” thus providing a superior method for the consumption of plant-based products.

Abstract: This invention relates to a pipette tip or tube designed to perform biological or chemical sample preparation, purification or separation. The narrow end of the pipette tip is twisted in such a way that it forms a narrow spiral passage, which allows the retention of the chromatographic material in the pipette tip. The narrow spiral formed by twisting the capillary or the tube creates an opening that is large enough to permit the passage of fluids or smaller particles, but small enough to block the passage of solid materials or larger particles, The device described herein can be used for sample separation or purification using a vacuum, pressure, centrifugation, gravitation or other separation methods.

Abstract: This invention relates to a pipette tip or tube designed to perform biological or chemical sample preparation, purification or separation. The narrow end of the pipette tip is twisted in such a way that it forms a narrow spiral passage, which allows the retention of the chromatographic material in the pipette tip. The narrow spiral formed by twisting the capillary or the tube creates an opening that is large enough to permit the passage of fluids or smaller particles, but small enough to block the passage of solid materials or larger particles, The device described herein can be used for sample separation or purification using a vacuum, pressure, centrifugation, gravitation or other separation methods.

Abstract: In the present invention, we describe a device and a method that shows the use of a perforated surface (e.g. net, grid, mesh etc.) for the preparation of small biological and chemical samples. In this present invention, the sample is concentrated on the edges of the perforation. If a solution of chemical or biological sample is applied on the perforated area; upon drying the solvent, the solute will concentrate on the edges of the perforation. This offers a novel method for the sample concentration. The perforated surface can be directly placed in the MALDI instrument for sample analysis. Furthermore, the edges of the perforation of the perforated surface can be modified, treated or coated with different chromatographic materials and thus have the retention property for analyzing the molecules. The woven net may contain not just single but double or more threads that creates a capillary effect, which further enhances the sample purification and concentration.

Abstract: The present invention relates to a novel device for transport of chemicals and biochemicals in small amounts such as in microgram range. For example, a pipette tip, or a film containing chromatographic media, wherein the media contains an enzyme for the enzymic action. The enzyme is adsorbed on the surface of the chromatographic media and is non-covalently bound. These enzyme containing tips will be used for the transport of very small amounts of enzyme to the sample, where the biochemical reaction takes place. They will also be used in a buffer where the enzyme will be kept adsorbed on the chromatographic media and will not dissociate from chromatographic media and the substrate will react with the enzyme on the surface of the media. Furthermore, the presence of chromatographic media can be used simultaneously for the purification of the reaction product from the buffer components.

Abstract: In the present invention we describe a vehicle for the transport of biologically active or therapeutic agents into organisms, such as human beings. The vehicle described in the present invention comprises mucin, wherein said mucin is present in a natural or modified form. The mucin component of the vehicle, as described in the present invention, serves to enhance the transport of biologically active agents, such as therapeutic agents into living organisms; to control and/or improve the delivery of biologically active agents to cells, tissues, organs or organelles; to increase the level of specificity in targeting particular cells or cells types; and/or, to enhance the activity of such therapeutic agents once they enter an organism.

Abstract: The present invention relates to a novel device for small sample preparation using tubes and columns, such as capillaries or pipette tips, in which particles of a separation medium, such as particles of a chromatography material used for sample preparation, are directly embedded in the solid material composing the tubes or columns. Most small sample preparation methods currently available cannot prevent sample loss and they are not well suited for small sample volumes. The present invention minimizes sample loss and is well suited for samples with volumes in nanoliters. In the invention described herein, the desired sample, such as a sample composed of biomolecules, is brought in contact with particles of the separation medium embedded on the surface of the device comprised of tubes and columns, according to the present invention.

Abstract: This invention relates to micro volume spin columns used for the preparation and purification of small chemical and/or biological samples by centrifugation. The present invention relates to the use of the conventional luer lock fitting in micro volume spin columns. This invention also relates to multi-spin column systems based on joining two or more spin columns by their ends or by combining different filtration or ultra-filtration membranes with spin columns.

Abstract: A device for warning when a low fluid level is reached is provided in which a levelness detecting switch is encapsulated in a conically shaped inert material (such as TEFLON.TM.), sized appropriately to the predetermined fluid limit, and coupled to an alarm device (such as an audible alarm, a frequency signal or a light).