Patents by Inventor Mukund Keshao Gurjar
Mukund Keshao Gurjar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090247545Abstract: The present invention provides substituted oxazolidinone derivatives, which can be used as antimicrobial agents. Compounds disclosed can be used for the treatment or prevention of a condition caused by or contributed to by bacteria, such as, inter alia, multiply-resistant Staphylococci, Streptococci, Enterococci, Bacterioides spp., Clostridium spp., Mycobacterium spp. Bacillus spp., Corynebacterium spp. Heptoslreptacoccus spp. Listeria spp., Legionella spp., Haemophilus influenza, Moraxella, Eschericia faecalis, and Eschericia coli. Processes for the preparation of disclosed compounds, pharmaceutical compositions thereof, and method of treating microbial infection are provided.Type: ApplicationFiled: December 28, 2004Publication date: October 1, 2009Inventors: Mukund Keshao Gurjar, Madhusudan Nagorao Deshmukh, Anita Mehta, Sudershan Kumar Arora, Ashok Rattan
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Patent number: 7109353Abstract: The present invention relates to an improved process for the preparation of 5,6-dihydro-4-(S)-(ethylamino)-6-(S)methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide hydrochloride of formula (I) commonly known as Dorzolamide Hydrochloride useful as an agent to reduce intraoccular pressure by inhibiting carbonic anhydrase enzymeType: GrantFiled: December 28, 2004Date of Patent: September 19, 2006Assignee: Council of Scientific and Industrial ResearchInventors: Mukund Keshao Gurjar, Madhusudan Nagorao Deshmukh, Vincent Paul, Venkatasubramaniam Radhakrishnan Tarur, Dhananjay Govind Sathe, Santosh Pratap Pardeshi, Sanjay Janardhan Naik, Tushar Anil Naik
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Patent number: 7041830Abstract: The Present invention relates to a process for the preparation of (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine of formula 1. (RS) 3-Methyl-1-(2-piperidinyl phenyl butyl amine having formula 1 is an important key intermediate for the synthesis of repaglinide of formula 2 an oral hypoglycemic agent.Type: GrantFiled: March 31, 2003Date of Patent: May 9, 2006Assignee: Council of Scientific and Industrial ResearchInventors: Uttam Ramrao Kalkote, Mukund Keshao Gurjar, Shreerang Vidyadhar Joshi, Suresh Mahadev Kadam, Harish Kashinath Mondkar
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Publication number: 20040192921Abstract: The Present invention relates to a process for the preparation of (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine of formula 1.Type: ApplicationFiled: March 31, 2003Publication date: September 30, 2004Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Uttam Ramrao Kalkote, Mukund Keshao Gurjar, Shreerang Vidyadhar Joshi, Suresh Mahadev Kadam, Harish Kashinath Mondkar
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Patent number: 6713639Abstract: The present invention relates to a process for the in situ preparation of optically pure (S)-3,4-dihydroxybutyric acid derivatives represented by the Formula [2] and more particularly, to a process which enables preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone represented by Formula [1] by oxidation of &agr;- or &bgr;-(1,4) linked disaccharide or oligosaccharide with an oxidant under basic condition to give acid and cyclization sequentially under acidic condition to give (S)-3-hydroxy-&ggr;-butyrolactone.Type: GrantFiled: October 28, 2002Date of Patent: March 30, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Mukund Keshao Gurjar, Pradeep Kumar, Anis Naim Deshmukh, Rajesh Kumar Upadhyay, Puspesh Kumar Upadhyay
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Patent number: 6566538Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.Type: GrantFiled: June 27, 2002Date of Patent: May 20, 2003Assignee: Millennium Pharmaceuticals, Inc.Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
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Patent number: 6541647Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1 -butynyl)-tetrahydrofuran and precursors thereof.Type: GrantFiled: October 2, 2001Date of Patent: April 1, 2003Assignee: Millennium Pharmaceuticals, Inc.Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Chittineni Hari Prasad, Alla Venkata Rama Rao
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Patent number: 6504044Abstract: A process for the preparation of 1-[(cyano) aryl methyl] cyclohexanol of the general formula 1 (1a-d) by reacting cyclohexanone with the carbanions of an aryl acetonitrile of the general formula 3 (3a-d), a) R1=H, R2=H b) R1=OMe R2=H c) R1=OMe R2=OMe d) R1=OMe R2=cyclopentyloxy using a base, isolating the compound of formula 1 and purifying the compound of formula 1a-d by crystallisation is disclosed.Type: GrantFiled: February 28, 2001Date of Patent: January 7, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Subhash Prataprao Chavan, Subhash Krishnaji Kamat, Latha Sivadasan, Kamalam Balakrishnan, Dushant Anandrao Khobragade, Ravindranathan Thottapillil, Mukund Keshao Gurjar, Uttam Ramrao Kalkote
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Publication number: 20020128491Abstract: A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±) trans-2-[5-(N′-methyl-N′-hydroxyureidyl-methyl)-3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.Type: ApplicationFiled: February 12, 2002Publication date: September 12, 2002Inventors: Alla Venkata Rama Rao, Mukund S. Chorghade, Amin ul Islam, Vemuri Venkata Kiran Rao, Anegondi Sreenivasa Prasad, Batchu Venkateswara Rao, Ranga Reddy, Lalata Krishnakanth Reddy, Kotakonda Shailaja, Mukund Keshao Gurjar, Sunil Vyankatesh Mhaskar
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Publication number: 20020120164Abstract: A process for the preparation of 1-[(cyano) aryl methyl] cyclohexanol of the general formula 1 (1a-d) by reacting cyclohexanone with the carbanions of an aryl acetonitrile of the general formula 3 (3a-d), 1Type: ApplicationFiled: February 28, 2001Publication date: August 29, 2002Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Subhash Prataprao Chavan, Subhash Krishnaji Kamat, Latha Sivadasan, Kamalam Balakrishnan, Dushant Anandrao Khobragade, Ravindranathan Thottapillil, Mukund Keshao Gurjar, Uttam Ramrao Kalkote
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Patent number: 6433197Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.Type: GrantFiled: October 2, 2001Date of Patent: August 13, 2002Assignee: Millennium Pharmaceuticals, Inc.Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
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Patent number: 6403814Abstract: A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N′-methyl-N′-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.Type: GrantFiled: October 15, 1999Date of Patent: June 11, 2002Assignee: Millennium Pharmaceuticals, Inc.Inventors: Alla Venkata Rama Rao, Mukund S. Chorghade, Amin ul Islam, Vemuri Venkata Kiran Rao, Anegondi Sreenivasa Prasad, Batchu Venkateswara Rao, Ranga Reddy, Lalata Krishnakanth Reddy, Kotakonda Shailaja, Mukund Keshao Gurjar, Sunil Vyankatesh Mhaskar
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Publication number: 20020040154Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.Type: ApplicationFiled: October 2, 2001Publication date: April 4, 2002Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
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Publication number: 20020035278Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereofType: ApplicationFiled: October 2, 2001Publication date: March 21, 2002Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Chittineni Hari Prasad, Alla Venkata Rama Rao
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Patent number: 6350912Abstract: A process for the preparation of 2-[dimethylamino-(4-methoxyphenyl)ethyl]-cyclohexanol of formula 1 by reducing 1-[cyano(4-methoxyphenyl)-methyl]cyclohexanol of formula 2 with a formylating agent in a protic solvent in the presence of a catalyst, removing the catalyst by filtration, isolating and purifying the compound of formula 1 is disclosed.Type: GrantFiled: February 28, 2001Date of Patent: February 26, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Subhash Prataprao Chavan, Subhash Krishnaji Kamat, Latha Sivadasan, Kamalam Balakrishnan, Dushant Anandrao Khobragade, Ravindranathan Thottapillil, Mukund Keshao Gurjar, Uttam Ramrao Kalkote
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Patent number: 6310221Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.Type: GrantFiled: July 2, 1999Date of Patent: October 30, 2001Assignee: Millennium Pharmaceuticals, Inc.Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Chittineni Hari Prasad, Alla Venkata Rama Rao
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Patent number: 6306895Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.Type: GrantFiled: July 2, 1999Date of Patent: October 23, 2001Assignee: Millenium Pharmaceuticals, Inc.Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
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Patent number: 6191279Abstract: The invention relates to novel dipyrano-quinolinone class of compounds having the general formula: Wherein R is hydrogen, alkyl optionally substituted about C-1 to C-10 alkenyl optionally substituted about C-1 to C-10 with one or more double bounds, alkynyl optionally substituted about C-1 to C-10 with one or more triple bonds, aryl, hetero aryl, carbocyclic aryl, alkyl aryl, alcyclic compounds, C-1 to C-6 alkyl with terminal dialkyl amino group, thio alkyl, hydroxyl alkyl groups; R1 is H, lower dialkyl amino alkyls such as methyl, ethyl, propyl, and other alkyl groups or b-amino acid moieties, hydroxy alkyl groups having optionally substituted about C-1 to C-10 carbons, acid amides such as aliphatic acids, aromatic acids, sulphonic acids trihalo acids.Type: GrantFiled: May 28, 1999Date of Patent: February 20, 2001Assignee: Council of Science & Industrial ResearchInventors: Mukund Keshao Gurjar, Gangavaram Vasantha Madhava Sharma, Aindivelu Ilangovan, Ven Narayanan