Abstract: Single-sided MRI apparatuses, systems, and methods are disclosed. A method can include transmitting a frequency sweep excitation pulse comprising a low-to-high frequency sweep; phase encoding during the frequency sweep excitation pulse; and tuning the amount of phase accumulated during the frequency sweep excitation pulse from adjacent slices in the slab. The frequency sweep excitation pulse can be a chirp pulse. Encoding in this way can prevent spin echoes from drifting and prevent k-space truncation in certain instances. Moreover, the resultant images can be combined more efficiently.

Abstract: A method for performing magnetic resonance imaging is provided. The method includes providing a magnetic resonance imaging system comprising: a radio frequency receive system comprising a radio frequency receive coil, and a housing, wherein the housing comprises a permanent magnet for providing an inhomogeneous permanent gradient field, a radio frequency transmit system, and a single-sided gradient coil set. The method also includes placing the receive coil proximate a target subject; applying a sequence of chirped pulses via the transmit system; applying a multi-slice excitation along the inhomogeneous permanent gradient field; applying a plurality of gradient pulses via the gradient coil set orthogonal to the inhomogeneous permanent gradient field; acquiring a signal of the target subject via the receive system, wherein the signal comprises at least two chirped pulses; and forming a magnetic resonance image of the target subject.

Abstract: Some embodiments of the present disclosure disclose systems and methods for robust magnetic resonance image reconstruction that can model for all or nearly all components in the magnetic resonance imaging system, that possess compressibility features to speed up reconstructions, and that can be optimized such that the reconstruction can be performed within a short period of time.

Abstract: A method for performing magnetic resonance imaging is provided. The method includes providing a magnetic resonance imaging system comprising: a radio frequency receive system comprising a radio frequency receive coil, and a housing, wherein the housing comprises a permanent magnet for providing an inhomogeneous permanent gradient field, a radio frequency transmit system, and a single-sided gradient coil set. The method also includes placing the receive coil proximate a target subject; applying a sequence of chirped pulses via the transmit system; applying a multi-slice excitation along the inhomogeneous permanent gradient field; applying a plurality of gradient pulses via the gradient coil set orthogonal to the inhomogeneous permanent gradient field; acquiring a signal of the target subject via the receive system, wherein the signal comprises at least two chirped pulses; and forming a magnetic resonance image of the target subject.

Abstract: A system of field cycled magnetic resonance system and a method of operating a field cycled magnetic resonance system are described. In accordance with various embodiments, the disclosed system includes a static field magnet, wherein the magnet is configured to provide a low static external magnetic field to a given field of view, a radio frequency coil, and a field cycling magnet. In accordance with various embodiments, the method includes providing a static field magnet configured to image a tissue sample within a given field of view, applying a low static external magnetic field to the given field of view, providing a radio frequency coil configured to produce cycling radio frequency field, providing a field cycling magnet, altering the low static external magnetic field within the given field of view, and collecting images from the system.

Abstract: In accordance with various embodiments, a magnetic resonance imaging system is provided. In accordance with various embodiments, the system includes a housing having a front surface, a permanent magnet for providing a static magnetic field, a radio N frequency transmit coil, and at least one gradient coil set. In accordance with various embodiments, the radio frequency transmit coil and the at least one gradient coil set are positioned proximate to the front surface. In accordance with various embodiments, the radio frequency transmit coil and the at least one gradient coil set are configured to generate an electromagnetic field in a region of interest. In accordance with various embodiments, the permanent magnet has an aperture through center of the permanent magnet. In accordance with various embodiments, the region of interest resides outside the front surface.

Abstract: Described herein are techniques and methods for measuring the chemical dynamics of a sample by monitoring the longitudinal and/or transverse relaxation rate of hyperpolarized xenon at low magnetic fields using a rubidium magnetometer.

Abstract: Described herein is a technique and method for analyzing the protein binding affinity of a drug. The techniques and methods described herein leverage magnetic resonance techniques such as NMR and MRI to make relaxation measurements of an NMR detectable species. In some embodiments, a rubidium polarizer is used to magnetize 129Xe, which is bubbled into a protein solution. The magnetic decay of the hyperpolarized 129Xe is monitored by measuring the T1 or T2 of 129Xe through NMR spectroscopy.