Abstract: Methods, apparatus, systems, and articles of manufacture providing a Bayesian compute unit with reconfigurable sampler and methods and apparatus to operate the same are disclosed. An example apparatus includes a processor element to generate (a) a first element by applying a mean value to an activation and (b) a second element by applying a variance value to a square of the activation, the mean value and the variance value corresponding to a single probability distribution; a programmable sampling unit to: generate a pseudo random number; and generate an output based on the pseudo random number, the first element, and the second element, wherein the output corresponds to the single probability distribution; and output memory to store the output.