Patents by Inventor Muneef AYYASH

Muneef AYYASH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230295575
    Abstract: Provided are methods of generating a metabolically mature human cell selected from the group consisting of a cardiomyocyte, a pancreatic beta cell, and a neuronal cell, using an effective concentration of a conjugated fatty acid and optionally a nonconjugated fatty acid selected from the group consisting of: a monounsaturated omega-9 fatty acid, palmitic acid, linoleic acid (LA) and a short chain fatty acid. Also provided are isolated populations of metabolically mature human cells, and methods and kits using same for selecting a compound for toxicity to the cells.
    Type: Application
    Filed: February 9, 2021
    Publication date: September 21, 2023
    Inventors: Yaakov Nahmias, Avner Ehrlich, Muneef Ayyash
  • Publication number: 20230070582
    Abstract: The present disclosure provides, in part, a cell culture medium comprising a serum-free medium and one or more fibroblast growth factor (FGF) activators, a kit comprising the cell culture medium and instructions for use, methods of growing cells in vitro and of producing a cultured meat using the cell culture medium, and a cultured meat so produced.
    Type: Application
    Filed: January 20, 2021
    Publication date: March 9, 2023
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov Nahmias, Muneef Ayyash, Laura Pasitka
  • Publication number: 20220042975
    Abstract: Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug.
    Type: Application
    Filed: August 22, 2021
    Publication date: February 10, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH, Muneef AYYASH
  • Publication number: 20210363495
    Abstract: A culture medium comprising a WNT inhibitor, a SRC inhibitor and a protein kinase C (PKC) inhibitor is disclosed. The medium is devoid of an amount of GSK3beta inhibitor that increases beta-catenin translocation to the nucleus of a pluripotent stem cell being cultured in the culture medium. Uses thereof are also disclosed.
    Type: Application
    Filed: July 22, 2021
    Publication date: November 25, 2021
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yaqub HANNA, Noa NOVERSHTERN, Tom Haim SHANI, Sergey VIUKOV, Rada MASSARWA, Jonathan BAYERL, Muneef AYYASH