Patents by Inventor Munir N. Nassar

Munir N. Nassar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FACTOR Xa INHIBITOR FORMULATION AND METHOD
    Publication number: 20090291913
    Abstract: An injectable Factor Xa inhibitor formulation is provided which includes the Factor Xa inhibitor razaxaban or apixaban, a solubilizing agent which is a substituted ?-cyclodextrin, preferably, sulfobutyl ether ?-cyclodextrin (SBE-CD) or hydroxypropyl-?-cyclodextrin (HPB-CD), and water. A method for preventing or treating venous thrombosis, deep venous thrombosis and acute coronary syndrome employing the above formulation is also provided.
    Type: Application
    Filed: August 4, 2009
    Publication date: November 26, 2009
    Applicant: Bristol-Myers Squibb Company
    Inventors: Munir N. Nassar, Uday S. Gogate, Timothy M. Malloy
  • Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol
    Patent number: 7157446
    Abstract: A ras-farnesyltransferase inhibitor complex formed from a ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, a substituted cyclodextrin, and ethanol is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor, improved dissolution, enhanced stability and is essentially free of particulate matter.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: January 2, 2007
    Assignee: Bristol Myers Squibb Company
    Inventors: Anne Marie Smith, Michael Cucolo, Munir N. Nassar
  • Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol
    Publication number: 20040235790
    Abstract: A ras-farnesyltransferase inhibitor complex formed from a ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, a substituted cyclodextrin, and ethanol is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor, improved dissolution, enhanced stability and is essentially free of particulate matter.
    Type: Application
    Filed: April 20, 2004
    Publication date: November 25, 2004
    Inventors: Anne Marie Smith, Michael Cucolo, Munir N. Nassar
  • Parenteral elsamitrucin formulations
    Patent number: 5508268
    Abstract: Stable parenteral antitumor formulations contain elsamitrucin salt, a stabilizer and a buffer. The formations are optionally stored in sealed containers under air or nitrogen headspace.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: April 16, 1996
    Assignee: Bristol-Myers Squibb
    Inventors: Munir N. Nassar, Michael J. Reff, Sheeram N. Agharkar
  • Injectable compositions of a cephalosporin dihydrate salt
    Patent number: 5401842
    Abstract: The present invention provides physical admixtures of a new crystalline dihydrochloride dihydrate salt of the cephalosporin antibiotic, cefepime with a pharmaceutically acceptable non-toxic organic or inorganic base. In particular, this invention provides physical admixtures having a temperature and moisture stable crystalline dihydrochloride dihydrate form of cefepime having a specific X-ray powder diffraction pattern as described herein.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: March 28, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Munir N. Nassar, Murray A. Kaplan
  • Lyophilized cefepime dihydrochloride for parenteral use
    Patent number: 5095011
    Abstract: A stable, amorphous, lyophilized dihydrochloride salt of 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(z)-methoxyiminoacetamido]-3-[(1- methyl-1-pyrrolidinium) methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily prepared than the crystalline counterpart and can be reconstituted in effective concentrations for intramuscular and intravenous injection utilizing suitable organic and inorganic bases to pH 3-7.0.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: March 10, 1992
    Assignee: Bristol-Myers Company
    Inventors: Murray A. Kaplan, Munir N. Nassar
  • Stable injectable antiemetic compositions
    Patent number: 4882356
    Abstract: Stable, injectable, aqueous solutions of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[(substituted)alkoxy]benzamid e antiemetic agents are prepared by adding, as stabilizing agent, a pharmaceutically acceptable, water-miscible, hydroxylic organic solvent or water-soluble polyhydric alcohol or sugar which decreases the polarity of the solution.
    Type: Grant
    Filed: March 10, 1987
    Date of Patent: November 21, 1989
    Inventors: Munir N. Nassar, Shreeram N. Agharkar, Joseph B. Bogardus