Abstract: The present invention relates to systems and methods for detecting and regulating neuroendocrine control. The systems involve measurement of real time pulsatile endocrine hormone levels in a subject and calculation of an appropriate dose of an analyte for treating the subject based on several factors. The systems are preferably closed loop systems.

Abstract: An apparatus for optimal control of distributed actuator and sensor arrays includes a control system having a state estimator including an operator which acts on estimation error through convolution with respect to a spatial variable to generate a state estimate, and a control output generator which applies a control operator to the state estimate through convolution with respect to the spatial variable. A method of designing an optimized control system includes the steps of obtaining a system model, computing a transform of the model with respect to the spatial domain, solving linear matrix inequalities to generate auxiliary variables, performing an inverse transform on the auxiliary variables, and computing an estimator operator and a control operator for a model-based estimator control system.

Abstract: In the context of associations between sets of objects, such as between two categorical data sets, a system and method of performing associations and determining optimizations thereof is presented. Performing various modifications of original object sets, such as by aggregating, refining and permuting the elements of the original object sets yield modified object sets corresponding to the original object sets. Functions and metrics are performed on the object sets, such as by calculating pair association values and overall association values to evaluate the strength or adequacy of an association. A process which iteratively modifies and re-evaluates the resulting associations of modified object sets is described, optionally checking for consistency or convergence of the result, optionally onto an optimum result and optionally checking a stopping criterion for terminating the process.