Abstract: A neurostimulation device includes a plurality of electrodes adapted to be electrically connected to a subject to receive multichannel electrical signals from the subject's brain, a multichannel seizure detection unit electrically connected to the plurality of electrical leads to receive the multichannel electrical signals, and a neurostimulation unit in communication with the multichannel seizure detection unit. The plurality of electrodes are at least three electrodes such that the multichannel electrical signals are at least three channels of electrical signals, and the multichannel seizure detection unit detects a presence of a seizure based on multichannel statistics from the multichannel electrical signals including higher order combinations than two-channel combinations.

Abstract: The present invention relates to systems and methods for detecting and regulating neuroendocrine control. The systems involve measurement of real time pulsatile endocrine hormone levels in a subject and calculation of an appropriate dose of an analyte for treating the subject based on several factors. The systems are preferably closed loop systems.

Abstract: A neurostimulation device includes a plurality of electrodes adapted to be electrically connected to a subject to receive multichannel electrical signals from the subject's brain, a multichannel seizure detection unit electrically connected to the plurality of electrical leads to receive the multichannel electrical signals, and a neurostimulation unit in communication with the multichannel seizure detection unit. The plurality of electrodes are at least three electrodes such that the multichannel electrical signals are at least three channels of electrical signals, and the multichannel seizure detection unit detects a presence of a seizure based on multichannel statistics from the multichannel electrical signals including higher order combinations than two-channel combinations. Another embodiment of the invention includes determining a singular vector centrality (SVC) for each of the electrodes in order to detect the seizure onset.

Abstract: A neurostimulation device includes a plurality of electrodes adapted to be electrically connected to a subject to receive multichannel electrical signals from the subject's brain, a multichannel seizure detection unit electrically connected to the plurality of electrical leads to receive the multichannel electrical signals, and a neurostimulation unit in communication with the multichannel seizure detection unit. The plurality of electrodes are at least three electrodes such that the multichannel electrical signals are at least three channels of electrical signals, and the multichannel seizure detection unit detects a presence of a seizure based on multichannel statistics from the multichannel electrical signals including higher order combinations than two-channel combinations.

Abstract: A method for selecting a target group of customers for promoting a product is based on data representing individual buying patterns for a pool of customers over a set of products a product to be promoted. A first subset of customers is selected whose buying patterns can form a behavioral benchmark for the selection of the target group of customers. A market model for the product set is constructed and a second subset of customers is selected who are considered to be potentially interested in a product to be promoted. The second subset of customers is scored according to their similarity to customer segments in the benchmark customer market model and a third subset is selected based upon their scores. Members of the third subset are matched to products according to product segments for which they have demonstrated similarity. Offer parameters indicating collaborative promotions can then be output.

Abstract: An apparatus for optimal control of distributed actuator and sensor arrays includes a control system having a state estimator including an operator which acts on estimation error through convolution with respect to a spatial variable to generate a state estimate, and a control output generator which applies a control operator to the state estimate through convolution with respect to the spatial variable. A method of designing an optimized control system includes the steps of obtaining a system model, computing a transform of the model with respect to the spatial domain, solving linear matrix inequalities to generate auxiliary variables, performing an inverse transform on the auxiliary variables, and computing an estimator operator and a control operator for a model-based estimator control system.

Abstract: In the context of associations between sets of objects, such as between two categorical data sets, a system and method of performing associations and determining optimizations thereof is presented. Performing various modifications of original object sets, such as by aggregating, refining and permuting the elements of the original object sets yield modified object sets corresponding to the original object sets. Functions and metrics are performed on the object sets, such as by calculating pair association values and overall association values to evaluate the strength or adequacy of an association. A process which iteratively modifies and re-evaluates the resulting associations of modified object sets is described, optionally checking for consistency or convergence of the result, optionally onto an optimum result and optionally checking a stopping criterion for terminating the process.