Patents by Inventor Munusamy Jayamani

Munusamy Jayamani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of 9-hydroxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one hydrochloride
    Patent number: 8071767
    Abstract: Described herein is an improved, commercially viable and industrially advantageous process for the preparation of paliperidone intermediate 9-hydroxy-3-(2-chloroethyl)-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one and its hydrochloride salt. The process provides the paliperidone intermediate in higher yield and reduced reaction time compared to the previously disclosed processes, thereby providing for production of paliperidone and its pharmaceutically acceptable acid addition salts in high purity and in high yield.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: December 6, 2011
    Assignee: Actavis Group PTC EHF
    Inventors: Uday Rajaram Bapat, Munusamy Jayamani, Sivaji Ravisaravanan, Vigneshwara Ravisankar
  • PROCESS FOR PREPARATION OF 9-HYDROXY-3-(2-CHLOROETHYL)-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE HYDROCHLORIDE
    Publication number: 20100004447
    Abstract: Described herein is an improved, commercially viable and industrially advantageous process for the preparation of paliperidone intermediate 9-hydroxy-3-(2-chloroethyl)-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one and its hydrochloride salt. The process provides the paliperidone intermediate in higher yield and reduced reaction time compared to the previously disclosed processes, thereby providing for production of paliperidone and its pharmaceutically acceptable acid addition salts in high purity and in high yield.
    Type: Application
    Filed: January 8, 2008
    Publication date: January 7, 2010
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Uday Rajaram Bapat, Munusamy Jayamani, Sivaji Ravisaravanan, Vigneshwara Ravisankar
  • Highly Pure Paliperidone or a Pharmaceutically Acceptable Salt Thereof Substantially Free of Keto Impurity
    Publication number: 20090247553
    Abstract: Provided herein is a highly pure paliperidone or a pharmaceutically acceptable salt thereof substantially free of keto impurity, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2-methyl-7,8-dihydro-6H-pyrido[1,2-a]pyrimidin-4,9-dione, a process for the preparation thereof, and pharmaceutical compositions comprising highly pure paliperidone or a pharmaceutically acceptable salt thereof substantially free of keto impurity.
    Type: Application
    Filed: March 26, 2009
    Publication date: October 1, 2009
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Uday Rajaram Bapat, Munusamy Jayamani, Sivaji Ravisaravanan, Vishal Amrutlal Sodha, Jon Valgeirsson