Patents by Inventor Muppala S. Raju

Muppala S. Raju has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereopreferential synthesis of 3-(1-phenylprop-2-yl)-5-phenyloxazolidinones
    Patent number: 5468865
    Abstract: The (R,R)-diastereoisomer of oxazolidin-2-ones, which are chemical intermediates for the preparation therapeutic agents useful in the treatment of diabetes and hyperglycemia, are prepared substantially free of isomeric forms through reduction of an acid addition salt of an (R)-N-protected-N-phenylcarboxymethyl-1-phenylprop-2-ylamine to form a secondary alcohol of predominantly the (R,R) chiral form in preference to others, removal of the protecting group to form a secondary amine, and allowing the secondary amine to react with a source of carbonyl groups. A typical embodiment involves the preparation of (R,R)-3-[1-(3,4-dimethoxyphenyl)prop-2-yl]-5-(3-chlorophenyl)oxazolidin-2- one in which both the chemical purity and optical purity are in excess of 99%.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: November 21, 1995
    Assignee: Celgene Corporation
    Inventors: Muppala S. Raju, Vikram Khetani
  • Resolution of hydroxychroman-2-carboxylic acid esters by enantiomeric hydrolysis
    Patent number: 5348973
    Abstract: Hydroxychroman-2-carboxylic acid esters can be resolved by enantiospecific hydrolysis by the use of liver enzymes, particularly solvent treated (acetone) enzymes. Liver enzymes from calf, cat, dog, eel, goat, lungfish, mouse, rat and seal have been found to be enantiospecific.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: September 20, 1994
    Assignee: Rhone-Poulenc Chimie
    Inventors: Muppala S. Raju, Namdol Huh
  • Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
    Patent number: 5346828
    Abstract: Mixtures of enantiomeric D,L-threo 2-amino-3-hydroxy-3-phenylpropionic acids can be stereoisomerically enriched by contacting the mixture with a D-threonine aldolase. In a typical embodiment, D- and L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid is treated with D-threonine aldolase to produce L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid with a high ee. The benzaldehyde and amino acid formed from the D-threo isomer can be recycled.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: September 13, 1994
    Assignee: Celgene Corporation
    Inventors: David I. Stirling, Muppala S. Raju, Andrew L. Zeitlin
  • Substituted phenoxypropionaldehyde derivates and their use as herbicidal agents
    Patent number: 4715882
    Abstract: The invention relates to certain substituted phenoxypropionaldehyde derivatives, formulations of said derivatives and the use thereof for preemergence or postemergence control of noxious plants, i.e., weeds.
    Type: Grant
    Filed: October 15, 1986
    Date of Patent: December 29, 1987
    Assignee: PPG Industries, Inc.
    Inventor: Muppala S. Raju
  • Herbicidally active 3-isoxazolyl-2-imidazolidinone derivatives
    Patent number: 4689071
    Abstract: This invention relates to certain 3-isoxazolyl-2-imidazolidinone derivatives, namely 3-[5- or 3-substituted -3- or -5-isoxazolyl]-1-,4- or 5-substituted-2-imidazolidinones and the use thereof for preemergence or post-emergence control of noxious plants, i.e., weeds.
    Type: Grant
    Filed: May 2, 1986
    Date of Patent: August 25, 1987
    Assignee: PPG Industries, Inc.
    Inventors: Muppala S. Raju, Jerome M. Lavanish
  • Substituted phenoxypropionaldehyde derivatives useful as herbicides
    Patent number: 4661149
    Abstract: The invention relates to certain substituted phenoxypropionaldehyde derivatives, formulations of said derivatives and the use thereof for preemergence or postemergence control of noxious plants, i.e., weeds.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: April 28, 1987
    Assignee: PPG Industries, Inc.
    Inventor: Muppala S. Raju