Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: The present disclosure provides fusion proteins comprising an IL-10 polypeptide and a second polypeptide, e.g., an Fc polypeptide. Certain aspects of the present disclosure are directed to methods of treating a subject comprising administering the IL-10 fusion protein. In certain aspects, the subject is afflicted with a cancer.

Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: The invention is directed to methods of treating cancer in subjects with a combination comprising a CCR2/5 dual antagonist, such as N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide; a monoclonal antibody, such as nivolumab; and/or chemotherapy.

Abstract: Methods and systems are disclosed for automated semantic tagging that include detecting a particular thread executed by a processor and identifying a root process of the particular thread. An object-process link may be by linking an object that executed code that called the particular thread to the root process. A thread list of thread definitions of the object may be identified. A particular thread definition that corresponds to the particular thread can be mapped. Resource types to be consumed upon executing an instance of the thread instantiated from the particular thread definition can be identified and the corresponding values of the resource types can be determined. A process specification can be generated that encapsulates the thread definition, resource types and values so as to reproduce a state of the root process at a point in which the particular thread executed.

Abstract: The invention is directed to methods of treating cancer in subjects with a combination comprising a CCR2/5 dual antagonist, such as N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide; a monoclonal antibody, such as nivolumab; and/or chemotherapy.

Abstract: The present invention describes methods of treating cancer, cancer metastasis, and drug resistant cancers using miRNA inhibitors; for example, inhibitors of miR-409-5p, miR-409-3p, miR-154*. Also described are methods of using the miRNA as biomarkers; for example, to predict responsiveness to a cancer drug, to detect a disease state of cancer.

Abstract: The present invention describes methods of treating cancer, cancer metastasis, and drug resistant cancers using miRNA inhibitors; for example, inhibitors of miR-409-5p, miR-409-3p, miR-154*. Also described are methods of using the miRNA as biomarkers; for example, to predict responsiveness to a cancer drug, to detect a disease state of cancer.

Abstract: The present invention describes methods of treating cancer, cancer metastasis, and drug resistant cancers using miRNA inhibitors; for example, inhibitors of miR-409-5p. Also described are methods of using the miRNA as biomarkers; for example, to predict responsiveness to a cancer drug, to detect a disease state of cancer.