Patents by Inventor Murali JAYARAMAN

Murali JAYARAMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CTLA4-IG FUSION PROTEIN FORMULATION
    Publication number: 20210179690
    Abstract: The present invention discloses a stable pharmaceutical formulation of a fusion protein, wherein the formulation contains buffer, sugar alcohol/polyol, amino acid and surfactant, and wherein the formulation is devoid of sucrose. Additionally, the formulation may also be devoid of a salt. The disclosed fusion protein formulations are liquid formulations that are also suitable for lyophilization.
    Type: Application
    Filed: May 24, 2019
    Publication date: June 17, 2021
    Applicant: DR. REDDY?S LABORATORIES LIMITED
    Inventors: Murali JAYARAMAN, Lakshmi KANAKADURGA M
  • ANTIBODY FORMULATION
    Publication number: 20210147555
    Abstract: The present invention discloses a stable pharmaceutical formulation of an antibody, wherein the formulation contains buffer, surfactant, sugar, and optionally contains a free amino acid. The disclosed formulation is stable at 50° C. for two weeks. In addition, the formulation maintains at least 96% of the antibody in monomeric form under above said storage conditions.
    Type: Application
    Filed: April 10, 2019
    Publication date: May 20, 2021
    Inventors: Murali JAYARAMAN, Anuja CHANDRASEKAR
  • STABLE LIQUID PHARMACEUTICAL COMPOSITION
    Publication number: 20210101987
    Abstract: The present invention provides a stable liquid formulation of an antibody in phosphate-amino acid based dual buffer system. The antibody formulated in phosphate-amino acid based dual buffer system imparts optimum stability to the antibody, at lower as well as higher concentrations. Further, the antibody formulated in phosphate-amino acid based buffer system has low viscosity and is suitable for therapeutic administration of high concentrations of antibody.
    Type: Application
    Filed: April 18, 2018
    Publication date: April 8, 2021
    Inventors: Murali JAYARAMAN, Pravin NAIR, Navneet KAUR, Deepak THUMBRAHALLI
  • STABLE PHARMACEUTICAL COMPOSITION
    Publication number: 20190284282
    Abstract: This present invention relates to a method of stabilizing an aqueous pharmaceutical preparation susceptible to de-gradation by formulating in a dual buffer system wherein the individual buffers are selected from phosphate, aspartate, glutamate, and succinate buffer.
    Type: Application
    Filed: January 11, 2017
    Publication date: September 19, 2019
    Applicant: Dr. Reddy's Laboratories Limited
    Inventors: Murali JAYARAMAN, Pravin NAIR, Lakshmi KANAKADURGA, Navneet KAUR, Deepak THUMBRAHALLI