Patents by Inventor Murali K. R. Tummuru

Murali K. R. Tummuru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TagA gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
    Patent number: 6153390
    Abstract: The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: November 28, 2000
    Assignee: Vanderbilt University
    Inventors: Timothy L. Cover, Martin J. Blaser, Harry Kleanthous, Murali K. R. Tummuru
  • Helicobacter TagA gene fusion protein
    Patent number: 5876943
    Abstract: The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: March 2, 1999
    Assignee: Vanderbilt University
    Inventors: Timothy L. Cover, Martin J. Blaser, Harry Kleanthous, Murali K. R. Tummuru
  • Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
    Patent number: 5733740
    Abstract: An isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: March 31, 1998
    Assignees: Vanderbilt University, OraVax, Inc.
    Inventors: Timothy L. Cover, Martin J. Blaser, Harry Kleanthous, Murali K. R. Tummuru
  • CagB and CagC genes of helicobacter pylori and related compositions
    Patent number: 5527678
    Abstract: A cagB gene of H. pylori is provided. This nucleic acid can be the nucleic acid consisting of nucleotides 193 through 1158 in the sequence set forth as SEQ ID NO:1, which is an example of a native coding sequence for CagB. This nucleic acid can also be in a vector suitable for expressing a polypeptide encoded by the nucleic acid. A cagC gene of H. pylori is provided. This nucleic acid can be the isolated nucleic acid consisting of nucleotides 1170 through 3830 in the sequence set forth as SEQ ID NO:3, which is an example of a native coding sequence for CagC. This nucleic acid can also be in a vector suitable for expressing a polypeptide encoded by the nucleic acid. Isolated nucleic acids that specifically hybridize with cagB and cagC are provided. CagB and CagC are associated with peptic ulceration and other clinical syndromes in humans infected with strains of H. pylori that express it.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: June 18, 1996
    Assignee: Vanderbilt University
    Inventors: Martin J. Blaser, Murali K. R. Tummuru, Smita A. Sharma
  • Taga gene and methods for detecting predisposition to peptic ulceration
    Patent number: 5403924
    Abstract: The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic fragment of the present invention and detecting the reaction of the antigen or fragment and the antibody. A mutant H. pylori not expressing a functional tagA antigen is also provided.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: April 4, 1995
    Assignee: Vanderbilt University
    Inventors: Timothy L. Cover, Murali K. R. Tummuru, Martin J. Blaser