Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

Abstract: The present invention relates to a compound represented by formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

Abstract: A golf ball includes an inner core layer formed from a thermoset rubber composition. The inner core layer has a first outer surface Shore D hardness and an outer diameter of about 0.8 to 1.40 inches. A thermoplastic outer core layer is formed around the inner core layer, has a second outer surface Shore D hardness, and is formed from a copolymer of ethylene and an ?,?-unsaturated carboxylic acid, a magnesium salt of oleic acid, and sufficient cation source to fully-neutralize the acid groups of the copolymer. The golf ball includes an inner cover layer and an outer cover layer. The first outer surface Shore D hardness is greater than the second outer surface Shore D hardness and the outer core layer has a thickness of about 0.01 inches to 0.05 inches.

Abstract: The present invention is directed to a golf ball and, more particularly, a golf ball core having a curable core composition comprising a dithiane compound, a rubber based compound comprising cis-1,4-polybutadiene rubber, a crosslinking agent comprising a metallic salt of unsaturated carboxylic acid in an amount between 10 to 50 parts per hundred of rubber (pphr), a peroxide initiator, one or more filler materials, and optionally an organ sulfur compound, are used to provide soft and resilient cores.

Abstract: The present invention provides golf balls having a rubber core, and a cover layer made from a thermoset polyurethane of polyurethane-urea that is the reaction product of a polyisocyanate with moisture-resistant polyol and curing agent. An intermediate layer, formed from an olefin-based acid copolymer ionomer composition and preferably an ethylene acid copolymer, is disposed between the rubber core and cover. The moisture-resistant polyol is preferably a reaction product of dimer acid or dimer ester and a polyolefin diol, or a polybutadiene polyol, or a polyisoprene. Preferably, the cover layer has a moisture vapor transmission rate (MVTR) between 3 grams·mm/m2·day to 4 grams·mm/m2·day.

Abstract: The present invention is directed to a golf ball and, more particularly, a golf ball having a polybutadiene based core, a cover disposed about the core, and optionally an intermediate layer disposed between the core and the cover. In one embodiment, at least one or more portions of the core, cover, or intermediate layer comprises a blend of thermoplastic or thermoset material and about 1 to 10 pphr of a nanocrystalline cellulose material.

Abstract: The present invention is directed to a golf ball and, more particularly, a golf ball core having a curable core composition comprising a dithiane compound, a rubber based compound comprising cis-1,4-polybutadiene rubber, a crosslinking agent comprising a metallic salt of unsaturated carboxylic acid in an amount between 10 to 50 parts per hundred of rubber (pphr), a peroxide initiator, one or more filler materials, and optionally an organ sulfur compound, are used to provide soft and resilient cores.

Abstract: Golf balls that have at least one layer formed from a cationic polyurea material. In particular, the compositions of the invention, which include a polymer backbone including urea linkages with cationic groups, may be formed from an isocyanate-containing component and an isocyanate-reactive component, at least one of which includes precursor cationic groups, in the presence of an alkylating, quaternizing, or ternarizing agent.

Abstract: Golf balls that have at least one layer formed from a cationic polyurea material. In particular, the compositions of the invention, which include a polymer backbone including urea linkages with cationic groups, may be formed from an isocyanate-containing component and an isocyanate-reactive component, at least one of which includes precursor cationic groups, in the presence of an alkylating, quaternizing, or ternarizing agent.

Abstract: The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

Abstract: Golf balls that have at least one layer formed from a cationic polyurea material. In particular, the compositions of the invention, which include a polymer backbone including urea linkages with cationic groups, may be formed from an isocyanate-containing component and an isocyanate-reactive component, at least one of which includes precursor cationic groups, in the presence of an alkylating, quaternizing, or ternarizing agent.

Abstract: A golf ball includes an inner core layer formed from a thermoset rubber composition. The inner core layer has a first outer surface Shore D hardness and an outer diameter of about 0.8 to 1.40 inches. A thermoplastic outer core layer is formed around the inner core layer, has a second outer surface Shore D hardness, and is formed from a copolymer of ethylene and an ?,?-unsaturated carboxylic acid, a magnesium salt of oleic acid, and sufficient cation source to fully-neutralize the acid groups of the copolymer. The golf ball includes an inner cover layer and an outer cover layer. The first outer surface Shore D hardness is greater than the second outer surface Shore D hardness and the outer core layer has a thickness of about 0.01 inches to 0.05 inches.

Abstract: A golf ball includes an inner core layer formed from a thermoset rubber composition. The inner core layer has a first outer surface Shore D hardness and an outer diameter of about 0.8 to 1.40 inches. A thermoplastic outer core layer is formed around the inner core layer, has a second outer surface Shore D hardness, and is formed from a copolymer of ethylene and an ?,?-unsaturated carboxylic acid, a magnesium salt of oleic acid, and sufficient cation source to fully-neutralize the acid groups of the copolymer. The golf ball includes an inner cover layer and an outer cover layer. The first outer surface Shore D hardness is greater than the second outer surface Shore D hardness and the outer core layer has a thickness of about 0.01 inches to 0.05 inches.

Abstract: Compositions for golf balls including modified highly neutralized polymeric compositions that have improved processability including improved melt flow index and improved performance characteristics when included in a layer of a golf ball. In addition, the compositions of the invention have less moisture transmission and higher flexural modulus than non-modified highly neutralized polymers.

Abstract: Golf equipment having improved cut and shear resistance that includes a polyurea composition, preferably saturated and/or water resistant, formed of a polyurea prepolymer and a curing agent, wherein the polyurea prepolymer includes an isocyanate and an amine-terminated compound, and wherein the curing agent includes a hydroxy-terminated curing agent, amine-terminated curing agent, or a mixture thereof.

Abstract: The present invention generally relates to golf balls and more particularly to golf balls having multi-layered cores comprising a thermoset rubber center, a thermoplastic intermediate core layer, and a thermoset rubber outer core layer. A cover layer is disposed about the multi-layered core. At least one of the center, intermediate core layer, and outer core layer comprises a polyalkenamer rubber. The polyalkenamer rubber may be blended with other rubbers such as polybutadiene, polyisoprene, ethylene propylene diene, and styrene-butadiene rubbers. The polyalkenamer rubber composition helps improve resiliency of the core and provides the ball with a comfortable and soft feel.

Abstract: This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.