Abstract: Methods and systems for combining electrically isolated LEDs and one or more laser diodes into a hybrid illumination device are presented herein. A hybrid LED and laser diode based illumination device includes both electrically isolated LEDs and one or more laser diodes assembled on common metal core printed circuit board. Employing electrically isolated LEDs allows the electrical connection of multiple LEDs in series on the common metal core printed circuit board with high spatial density. In some embodiments, a laser diode source is located within a spatial envelope of an LED array to realize a particularly compact, high optical power, hybrid LED and laser diode based illumination device with a relatively small illumination source etendue. In a further aspect, different sets of LEDs and one or more laser diodes are independently controlled to generate illumination with different spectral characteristics.