Patents by Inventor Muralidhara Padigaru

Muralidhara Padigaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040029150
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 31, 2003
    Publication date: February 12, 2004
    Inventors: John Alsobrook, David Anderson, Ferenc Boldog, Catherine Burgess, Stacie Casman, Shlomit R. Edinger, Valerie Gerlach, William Grosse, Xiaojia Guo, Vladimir Gusev, Weizhen Ji, William LaRochelle, Denise Lepley, Li Li, Xiaohong Liu, John R. MacDougall, Uriel M. Malyankar, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John A. Peyman, Luca Rastelli, Daniel Rieger, Mark E. Rothenberg, Richard Shimkets, David J. Stone, Raymond Taupier, Corine Vernet, Bryan Zerhusen
  • Publication number: 20040029790
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: July 2, 2002
    Publication date: February 12, 2004
    Inventors: Meera Patturajan, Valerie Gerlach, David W. Anderson, Raymond J. Taupier, Bryan D. Zerhusen, Xiaojia Sasha Guo, Stacie J. Casman, Tord Hjalt, Charles E. Miller, Ramesh Kekuda, Richard A. Shimkets, Uriel M. Malyankar, Mei Zhong, Muralidhara Padigaru, Li Li, Suresh G. Shenoy, Linda Gorman, Shlomit R. Edinger
  • Publication number: 20040030096
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: August 1, 2002
    Publication date: February 12, 2004
    Inventors: Linda Gorman, Bryan D. Zerhusen, Shlomit R. Edinger, Muralidhara Padigaru, Xiaojia (Sasha) Guo, Ramesh Kekuda, Mei Zhong, Meera Patturajan, Charles E. Miller, Weizhen Ji, Carol E. A. Pena, Catherine E. Burgess, Paul Sciore, David J. Stone, Raymond J. Taupier, Stacie J. Casman, Mark E. Rothenberg, Uriel M. Malyankar, Ferenc L. Boldog
  • Publication number: 20040030110
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
    Type: Application
    Filed: April 2, 2002
    Publication date: February 12, 2004
    Inventors: Xiaojia (Sasha) Guo, Ramesh Kekuda, Charles E. Miller, Uriel M. Malyankar, Kimberly A. Spytek, Meera Patturajan, Xiaohong Liu, Vladimir Y. Gusev, Li Li, Corine A.M. Vernet, Bryan D. Zerhusen, Linda Gorman, Suresh G. Shenoy, Carol E. A. Pena, Glennda Smithson, Catherine E. Burgess, Valerie Gerlach, Muralidhara Padigaru, Richard A. Shimkets, Esha A. Gangolli, Raymond J. Taupier, Stacie J. Casman, Weizhen Ji, David W. Anderson, Mario W. Leite, Luca Rastelli, Shlomit R. Edinger, David J. Stone, John R. MacDougall, Mark E. Rothenberg, Ann Mazur, Isabelle Millet, John A. Peyman, Karen Ellerman
  • Publication number: 20040024181
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: October 26, 2001
    Publication date: February 5, 2004
    Inventors: Esha A. Gangolli, Kimberly A. Spytek, Jennifer Gilbert, Stacie Casman, Angela Blalock, Li Li, Corine Vernet, Suresh Shenoy, Vishnu S. Mishra, Katarzyna Furtak, Valerie L. Gerlach, Shlomit Edinger, Uriel Malyanker, David Stone, Isabelle Millet, Glennda Smithson, Erik Gunther, Karen Ellerman, Muralidhara Padigaru, Raymond J. Taupier, David W. Anderson
  • Publication number: 20040018977
    Abstract: The proteins of the invention are a family used to modulate the activity of cells and their ability to attract blood vessels. The proteins are used to inhibit angiogenesis, inhibit cell migration, and inhibit actin filament formation. These proteins are used in this context to diagnose and treat proliferative disorders such as cancer.
    Type: Application
    Filed: May 30, 2003
    Publication date: January 29, 2004
    Inventors: Enrique Alvarez, David W. Anderson, Mohanraj Dhanabal, Nikolai V. Khramtsov, William J. LaRochelle, Henri S. Lichenstein, Li Li, Chean Eng Ooi, Muralidhara Padigaru, Richard A. Shimkets, Mei Zhong
  • Publication number: 20040018555
    Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
    Type: Application
    Filed: June 3, 2002
    Publication date: January 29, 2004
    Inventors: David W. Anderson, Bryan D. Zerhusen, Li Li, Mei Zhong, Stacie J. Casman, Valerie Gerlach, Richard A. Shimkets, Linda Gorman, Carol E. A. Pena, Ramesh Kekuda, Meera Patturajan, Kimberly A. Spytek, Mario W. Leite, Luca Rastelli, John R. MacDougall, Raymond J. Taupier, Xiaojia Sasha Guo, Charles E. Miller, Suresh G. Shenoy, Tord Hjalt, Edward Z. Voss, Ferenc L. Boldog, Uriel M. Malyankar, Muralidhara Padigaru, Weizhen Ji, Glennda Smithson, Shlomit R. Edinger, Isabelle Millet, Karen Ellerman
  • Publication number: 20040018594
    Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
    Type: Application
    Filed: May 1, 2002
    Publication date: January 29, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Shlomit R. Edinger, Valerie Gerlach, Linda Gorman, Erik Gunther, Xiaojia Sasha Guo, Ramesh Kekuda, Denise M. Lepley, Li Li, Xiaohong Liu, Uriel M. Malyankar, Charles E. Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Suresh G. Shenoy, Richard A. Shimkets, Kimberly A. Spytek, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen
  • Publication number: 20040014053
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: August 1, 2002
    Publication date: January 22, 2004
    Inventors: Bryan D. Zerhusen, Meera Patturajan, Ramesh Kekuda, Charles E. Miller, Daniel K. Rieger, Carol E.A. Pena, Richard A. Shimkets, Li Li, Constance Berghs, Mei Zhong, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Muralidhara Padigaru, Glennda Smithson, Weizhen Ji, Linda Gorman, Corine A.M. Vernet, Mario W. Leite, Xiaojia Sasha Guo, David W. Anderson, Kimberly A. Spytek, Valerie Gerlach, Catherine E. Burgess, Nikolai V. Khramtsov, Tatiana Ort, Karen Ellerman, Luca Rastelli, Michele L. Agee, Amitabha Chaudhuri, John S. Chant, Vincent A. DiPippo, Shlomit R. Edinger, Andrew J. Eisen, Esha A. Gangolli, Loic Giot, Chean Eng Ooi, Mark E. Rothenberg, Steven K. Spaderna, Tord Hjalt, Xiaohong Liu, Raymond J. Taupier, Elina Catterton, Suresh G. Shenoy
  • Publication number: 20040014081
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: February 18, 2003
    Publication date: January 22, 2004
    Inventors: John P. Alsobrook, Steven K. Spaderna, Velizar T. Tchernev, Xiaohong Liu, Suresh G. Shenoy, Kimberly A. Spytek, Bryan D. Zerhusen, Meera Patturajan, Raymond J. Taupier, Luca Rastelli, William M. Grosse, Edward S. Szekeres, Denise M. Lepley, Lei Shen, Catherine E. Burgess, Richard A. Shimkets, Muralidhara Padigaru
  • Publication number: 20040014038
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 3, 2002
    Publication date: January 22, 2004
    Inventors: Stacie J. Casman, Shlomit R. Edinger, Karen Ellerman, Glennda Smithson, Ramesh Kekuda, Muralidhara Padigaru
  • Publication number: 20040014173
    Abstract: The present invention provides novel polypeptides, termed SECX polypeptides, as well as polynucleotides encoding SECX polypeptides and antibodies that immunospecifically bind to SECX or a derivative, variant, mutant, or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to others uses.
    Type: Application
    Filed: March 10, 2003
    Publication date: January 22, 2004
    Inventors: David W. Anderson, Ferenc L. Boldog, Stacie J. Casman, Shlomit R. Edinger, Karen Ellerman, Elma R. Fernandes, Erik Gunther, Martin D. Leach, John R. MacDougall, Muralidhara Padigaru, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek
  • Publication number: 20040010120
    Abstract: The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Application
    Filed: April 7, 2003
    Publication date: January 15, 2004
    Inventors: Uriel M. Malyankar, Velizar T. Tchernev, Muralidhara Padigaru, Raymond J. Taupier, Kimberly A. Spytek, Xiaojia (Sasha) Guo, Steven K. Spaderna, Ferenc L. Boldog, Valerie Gerlach, Karen Ellerman, John R. MacDougall, Glennda Smithson
  • Publication number: 20040010118
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: August 15, 2001
    Publication date: January 15, 2004
    Inventors: Bryan D. Zerhusen, Muralidhara Padigaru, Kimberly Spytek, Steven Spaderna, Esha A. Gangolli, Luca Rastelli, Catherine E. Burgess, Kumud Majumder, Richard Shimkets, Vishnu Mishra, Corine Vernet, Edward S. Szekeres, William M. Grosse, John P. Alsobrook, Xiaohong Liu, Valerie L. Gerlach, Karen Ellerman, Glennda Smithson, John Peyman, David Stone, John MacDougall
  • Publication number: 20040009907
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: February 25, 2002
    Publication date: January 15, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Robert A. Ballinger, Ference L. Boldog, Catherine E. Burgess, Stacie J. Casman, Karen Ellerman, Esha A. Gangolli, Valerie Gerlach, Jennifer A. Gilbert, Linda Gorman, Xiaojia (Sasha) Guo, Vladimir Y. Gusev, Ramesh Kekuda, Li Li, Xiaohong Liu, Uriel M. Malyankar, Charles E. Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Raymond J. Taupier, Velizar T. Tchernev, Corine A.M. Vernet, Bryan D. Zerhusen
  • Publication number: 20040009480
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 3, 2002
    Publication date: January 15, 2004
    Inventors: David W. Anderson, Jason C. Baumgartner, Ferenc L. Boldog, Stacie J. Casman, Shlomit R. Edinger, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia Sasha Guo, Tord Hjalt, Ramesh Kekuda, Li Li, John R. MacDougall, Uriel M. Malyankar, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Richard A. Shimkets, David J. Stone, Kimberly A. Spytek, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen
  • Publication number: 20040005576
    Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
    Type: Application
    Filed: August 30, 2002
    Publication date: January 8, 2004
    Inventors: Xiaojia (Sasha) Guo, Li Li, Meera Patturajan, Richard A. Shimkets, Stacie J. Casman, Uriel M. Malyankar, Velizar T. Tchernev, Corine A. Vernet, Kimberly A. Spytek, Suresh G. Shenoy, John P. Alsobrook, Schlomit Edinger, John A. Peyman, David J. Stone, Karen Ellerman, Esha A. Gangolli, Ferenc L. Boldog, Steven D. Colman, Andrew Eisen, Xiaohong Liu, Muralidhara Padigaru, Steven K. Spaderna, Bryan D. Zerhusen
  • Publication number: 20040005656
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: October 16, 2001
    Publication date: January 8, 2004
    Inventors: Ramesh Kekuda, Kimberly A. Spytek, Stacie J. Casman, Bryan D. Zerhusen, Li Li, Velizar T. Tchernev, Steven D. Colman, Robert A. Ballinger, Muralidhara Padigaru, Adam R. Wolenc, Suresh G. Shenoy, Shlomit R. Edinger, Valerie Gerlach, Esha A. Gangolli, John R. MacDougall, Glennda Smithson, John A. Peyman, David J. Stone, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess
  • Publication number: 20040005557
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 16, 2002
    Publication date: January 8, 2004
    Inventors: Muralidhara Padigaru, John P. Alsobrook, Steven D. Colman, Kimberly A. Spytek, Ferenc L. Boldog, Corine A.M. Vernet, Li Li, Suresh G. Shenoy, Stacie J. Casman, Xiaojia (Sasha) Guo, Shlomit R. Edinger, John R. MacDougall, Uriel M. Malyankar, Meera Patturajan, Richard A. Shimkets, Carol E. A. Pena, Velizar T. Tchernev, Bryan D. Zerhusen, Isabelle Millet, Charles E. Miller, Denise M. Lepley, Glennda Smithson, Jason C. Baumgartner, John L. Herrmann, John A. Peyman, Linda Gorman, Peter D. Mezes, Ramesh Kekuda, Raymond J. Taupier, Valerie Gerlach, William M. Grosse, Xiaohong Liu, Karen Ellerman, Mark Rothenberg, David J. Stone, Catherine E. Burgess
  • Publication number: 20040002120
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 7, 2002
    Publication date: January 1, 2004
    Inventors: Ramesh Kekuda, Velizar T. Tchernev, Xiaohong Liu, Kimberly A. Spytek, Meera Patturajan, Catherine E. Burgess, Corine A.M. Vernet, Li Li, Linda Gorman, Uriel M. Malyankar, Ferenc L. Boldog, Xiaojia (Sasha) Guo, Suresh G. Shenoy, Muralidhara Padigaru, Raymond J. Taupier, Charles E. Miller, Stacie J. Casman, Carol E. A. Pena, Esha A. Gangolli, Vladimir Y. Gusev, Glennda Smithson, Bryan D. Zerhusen, Valerie Gerlach, Pascale F-J Pochart, Elma R. Fernandes, Richard A. Shimkets, Luca Rastelli, Steven K. Spaderna, William J. LaRochelle, Mei Zhong, Nikolai V. Khramtsov, Edward Z. Voss, John L. Herrmann