Patents by Inventor Murat Cirit

Murat Cirit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250122456
    Abstract: A modular multi-tissue chip (MTC) microphysiological system (MPS) platform has integrated sensors and real-time data analysis software for immune engineering and CBRN studies that can be deployed by expert labs for rapid testing.
    Type: Application
    Filed: September 25, 2024
    Publication date: April 17, 2025
    Inventor: Murat Cirit
  • Publication number: 20240228927
    Abstract: A microfluidic chip is configured to determine DILI parameters. The microfluidic chip includes a cell chamber hosting a tissue culture comprising liver tissue; a reoxygenation chamber configured to add oxygen to a fluid media; a fluid loop configured to recirculate the fluid media through the cell chamber and the reoxygenation chamber and supply oxygenated fluid media to the tissue culture; and an oxygen sensor configured to measure an oxygen concentration within the fluid media. The microfluidic chip includes a controller configured to perform operations including recirculating the fluid media in the fluid loop, the fluid media comprising a drug dose; obtaining measurements of the oxygen concentration at a sequence of time points during recirculating; and determining, based on the measured oxygen concentration, at least one physiologic parameter value of the tissue culture that describes a clinical test metric describing a damage level to the tissue culture.
    Type: Application
    Filed: January 5, 2024
    Publication date: July 11, 2024
    Inventor: Murat Cirit
  • Publication number: 20240150696
    Abstract: This disclosure describes hardware for microfluidic chips and an associated platform for facilitating operation of one or more microfluidic chips. The microfluidic chips described herein are designed for supporting multiple different tissue types, including kidney tissue, liver tissue, adipose cells, and so forth. Chip geometry facilities fluid flow through one or more channels of the chip with a particular flow rate. For example, shear forces are reduced where needed to ensure proper flow rate of fluid in the channels. The chamber geometry and the geometry of the channels ensures that a desired amount of oxygen is delivered to sample cells or tissues in a controlled manner.
    Type: Application
    Filed: November 7, 2023
    Publication date: May 9, 2024
    Inventors: Shiny Amala Priya Rajan, Jacob Dylan Freake, Corbin Munn, Murat Cirit
  • Publication number: 20230330668
    Abstract: A microphysiological system (MPS) includes at least one first inlet for receiving a fluid medium. The MPS includes a brain module comprising brain tissue. The MPS includes a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium. The MPS includes a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module. The MPS is configured for treating the brain tissue and the BBB tissue with a drug or a combination of drugs to determine a phenotypic effect and a transcriptomic effect of the drug. A drug perturbation is related to the phenotypic effect and the transcriptomic effect based on kinetic optimization.
    Type: Application
    Filed: June 23, 2023
    Publication date: October 19, 2023
    Inventors: Murat Cirit, Begum Alaybeyoglu, Jason Samuel Sherfey, John Wayne Rumsey, Yoojin Shin
  • Patent number: 11738340
    Abstract: A microphysiological system (MPS) includes at least one first inlet for receiving a fluid medium. The MPS includes a brain module comprising brain tissue. The MPS includes a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium. The MPS includes a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module. The MPS is configured for treating the brain tissue and the BBB tissue with a drug or a combination of drugs to determine a phenotypic effect and a transcriptomic effect of the drug. A drug perturbation is related to the phenotypic effect and the transcriptomic effect based on kinetic optimization.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: August 29, 2023
    Assignee: Javelin Biotech, Inc.
    Inventors: Murat Cirit, Begum Alaybeyoglu, Jason Samuel Sherfey, John Wayne Rumsey, Yoojin Shin
  • Publication number: 20230058647
    Abstract: This disclosure describes hardware for microfluidic chips and an associated support module for facilitating operation of one or more microfluidic chips. The microfluidic chips described herein are designed for supporting multiple different tissue types, including kidney tissue, liver tissue, adipose cells, and so forth. Chip geometry facilities fluid flow through one or more channels of the chip with a particular flow rate. For example, shear forces are reduced where needed to ensure proper flow rate of fluid in the channels. The chamber geometry and the geometry of the channels ensures that a desired amount of oxygen is delivered to sample cells or tissues in a controlled manner.
    Type: Application
    Filed: August 19, 2022
    Publication date: February 23, 2023
    Inventors: Murat Cirit, Douglas G. Sabin, Peter Conway, Jacob Freake, Corbin Munn, Joseph Von Shoppe, Renee Hester, Emily Geishecker, Shiny Rajan, Abraham LeMole
  • Publication number: 20220074924
    Abstract: Microfluidic platforms including multiple microphysiological systems. At least one of the platforms include: at least one inlet; a plurality of organ constructs, each organ construct of the plurality of organ constructs being sized relative to other organ constructs of the plurality of organ constructs based on at least one predetermined human pharmacokinetic (PK) parameter; and a plurality of channels, each channel of the plurality of channels causing an organ construct of the plurality of organ constructs to be in fluidic communication with at least one other organ construct of the plurality of organ constructs.
    Type: Application
    Filed: September 4, 2020
    Publication date: March 10, 2022
    Inventor: Murat Cirit
  • Publication number: 20210301238
    Abstract: Microfluidic platforms including multiple microphysiological systems. At least one of the platforms include: at least one inlet; a plurality of organ constructs, each organ construct of the plurality of organ constructs being sized relative to other organ constructs of the plurality of organ constructs based on at least one predetermined human pharmacokinetic (PK) parameter; and a plurality of channels, each channel of the plurality of channels causing an organ construct of the plurality of organ constructs to be in fluidic communication with at least one other organ construct of the plurality of organ constructs.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 30, 2021
    Inventor: Murat Cirit
  • Publication number: 20210156846
    Abstract: A method for developing stratified medicine for nonalcoholic fatty liver disease (NAFLD includes obtaining a microphysiological system (MPS) comprising a liver tissue cytoarchitecture, adipose tissue, or both. The method includes inducing metabolic dysfunction representing NAFLD in the liver or adipose tissue of the MPS. The method includes generating, based on inducing the metabolic dysfunction, transcriptomics data for the MPS. The method includes applying a drug to the MPS using a dosing regimen. The method includes monitoring changes in the transcriptomics data based on applying the drug. The method includes generating a model relating the changes in the transcriptomics data to the dosing regimen of the drug.
    Type: Application
    Filed: November 25, 2020
    Publication date: May 27, 2021
    Inventors: Murat Cirit, Begum Alaybeyoglu, Nathan Brent Sorensen, John Wayne Rumsey
  • Publication number: 20210101146
    Abstract: A microphysiological system (MPS) includes at least one first inlet for receiving a fluid medium. The MPS includes a brain module comprising brain tissue. The MPS includes a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium. The MPS includes a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module. The MPS is configured for treating the brain tissue and the BBB tissue with a drug or a combination of drugs to determine a phenotypic effect and a transcriptomic effect of the drug. A drug perturbation is related to the phenotypic effect and the transcriptomic effect based on kinetic optimization.
    Type: Application
    Filed: October 5, 2020
    Publication date: April 8, 2021
    Inventors: Murat Cirit, Begum Alaybeyoglu, Jason Samuel Sherfey, John Wayne Rumsey, Yoojin Shin