Patents by Inventor Muriel Bardor
Muriel Bardor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170247714Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.Type: ApplicationFiled: March 30, 2017Publication date: August 31, 2017Applicants: Medicago, Inc., Centre National de la Recherche Scientifique, Universite De RouenInventors: Thomas PACCALET, Muriel BARDOR, Christophe RIHOUEY, Véronique GOMORD, Loïc FAYE, Patrice LEROUGE, Stéphanie AQUIN, Louis-Philippe VEZINA, Marc-André D'AOUST
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Patent number: 9657305Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.Type: GrantFiled: November 4, 2015Date of Patent: May 23, 2017Assignees: Medicago Inc., Centre National de la Recherche Scientifique, Universite De RouenInventors: Thomas Paccalet, Muriel Bardor, Christophe Rihouey, Véronique Gomord, Loïc Faye, Patrice Lerouge, Stéphanie Aquin, Louis-Philippe Vezina, Marc-André D'Aoust
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Patent number: 9587245Abstract: Transformed Phaeodactylum tricornutum including a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an N-acetylglucosaminyltransferase I and/or an ?-Mannosidase II and wherein at least one ?-N-acetylglucosaminidase of the transformed Phaeodactylum tricornutum has been inactivated. A method for producing a glycosylated polypeptide includes the steps of (i) culturing a transformed P. tricornutum as defined previously and (ii) purifying the polypeptide that is expressed and glycosylated in the transformed P. Tricornutum. The use of such a transformed P. tricornutum for producing a glycosylated polypeptide is also described.Type: GrantFiled: July 27, 2011Date of Patent: March 7, 2017Assignees: UNIVERSITE DE ROUEN, L'INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), ALGENICSInventors: Muriel Bardor, Romain Louvet, Bruno Saint-Jean, Carole Burel, Bérangère Baiet, Jean-Paul Cadoret, Patrice Lerouge, Rémy Michel, Aude Carlier
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Publication number: 20160145664Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.Type: ApplicationFiled: November 4, 2015Publication date: May 26, 2016Applicants: Medicago Inc., Centre National de la Recherche Scientifique, Universite De RouenInventors: Thomas PACCALET, Muriel BARDOR, Christophe RIHOUEY, Véronique GOMORD, Loïc FAYE, Patrice LEROUGE, Stéphanie AQUIN, Louis-Philippe VEZINA, Marc-André D'AOUST
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Patent number: 9212372Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.Type: GrantFiled: February 9, 2007Date of Patent: December 15, 2015Assignees: Medicago Inc., Centre National de la Recherche Scientifique, Université De RouenInventors: Thomas Paccalet, Muriel Bardor, Christophe Rihouey, Véronique Gomord, Loïc Faye, Patrice Lerouge, Stéphanie Aquin, Louis-Philippe Vezina, Marc-André D'Aoust
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Publication number: 20140154707Abstract: Transformed Phaeodactylum tricornutum including a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an N-acetylglucosaminyltransferase I and/or an ?-Mannosidase II and wherein at least one ?-N-acetylglucosaminidase of the transformed Phaeodactylum tricornutum has been inactivated. A method for producing a glycosylated polypeptide includes the steps of (i) culturing a transformed P. tricornutum as defined previously and (ii) purifying the polypeptide that is expressed and glycosylated in the transformed P. Tricornutum. The use of such a transformed P. tricornutum for producing a glycosylated polypeptide is also described.Type: ApplicationFiled: July 27, 2011Publication date: June 5, 2014Applicants: UNIVERSITE DE ROUEN, L'INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER), ALGENICSInventors: Muriel Bardor, Romain Louvet, Bruno Saint-Jean, Carole Burel, Berangere Baiet, Jean-Paul Cadoret, Patrice Lerouge, Remy Michel, Aude Carlier
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Patent number: 8728761Abstract: Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides.Type: GrantFiled: February 12, 2009Date of Patent: May 20, 2014Assignees: Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), Centre National de la Recherche Scientifique—CNRS, Universite de RouenInventors: Jean-Paul Cadoret, Aude Carlier, Patrice Lerouge, Muriel Bardor, Carole Burel, Florian Maury
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Publication number: 20110045533Abstract: Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides.Type: ApplicationFiled: February 12, 2009Publication date: February 24, 2011Applicant: UNIVERSITE DE ROUENInventors: Jean-Paul Cadoret, Aude Carlier, Patrice Lerouge, Muriel Bardor, Carole Burel, Florian Maury
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Publication number: 20110008837Abstract: A method for synthesizing a protein of interest with a modified N-glycosylation profile within a plant, a portion of a plant, or a plant cell is provided. The method comprises co-expressing within a plant a nucleotide sequence encoding a first nucleotide sequence encoding a hybrid protein (GNT1-GalT) comprising a CTS domain of N-acetylglucosaminyl transferase (GNT1) fused to a catalytic domain of beta-1,4galactosyltransferase (GalT), the first nucleotide sequence operatively linked with a first regulatory region that is active in the plant, and a second nucleotide sequence for encoding the protein of interest, the second nucleotide sequence operatively linked with a second regulatory region that is active in the plant. The first and second nucleotide sequences are co-expressed to synthesize a protein of interest comprising glycans with the modified N-glycosylation profile within the plant, the portion of the plant, or the plant cell.Type: ApplicationFiled: June 13, 2008Publication date: January 13, 2011Inventors: Marc-Andre D-Aoust, Louis-Philippe Vezina, Stephanie Aquin, Estelle Marquet-Blouin, Muriel Bardor, Veronique Gomord, Christophe Rihouey, Thomas Paccalet, Carole Burel, Loic Faye, Patrice Lerouge, Christophe Sourrouille
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Publication number: 20090312240Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated a protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, CMP-Neu5Ac transporter and a sialyltransferase.Type: ApplicationFiled: February 9, 2007Publication date: December 17, 2009Inventors: Thomas Paccalet, Muriel Bardor, Chirstophe Rihouey, Véronique Gomord, Loïc Faye, Patrice Lerouge, Stéphanie Aquin, Louis-Philippe Vezina, Marc-André D'Aoust