Patents by Inventor Muriel Pipelier

Muriel Pipelier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW IMMUNOSTIMULATORS AND USE THEREOF IN IMMUNOTHERAPY
    Publication number: 20230088717
    Abstract: The present invention relates to a new family of iNKT stimulators, referred to as 6?-O-PEGm-NHR-GalCer, which are potent analogues of KRN7000. These iNKT stimulators can advantageously be used in therapy, in particular for the prevention and/or treatment of many diseases requiring a stimulation of an immune response, such as cancer, viral, bacterial or parasitic diseases, autoimmune diseases or inflammatory diseases. The iNKT cell stimulator of the invention may be coupled to a biological carrier, such as a therapeutic and/or targeting agent, or be vectorized, for example in nanoparticles, to be specifically delivered to target cells.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 23, 2023
    Inventors: Didier DUBREUIL, Allan PATINEC, Muriel PIPELIER, Jacques LE PENDU, Jacques LEBRETON, Virginie BLOT, Arnaud TESSIER
  • Method for making biochips
    Patent number: 9266726
    Abstract: A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method. Also, a kit for the preparation of the chips.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: February 23, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE (C.N.R.S), UNIVERSITE DE NANTES, UNIVERSITY OF FLORIDA
    Inventors: Charles Tellier, Muriel Pipelier, Didier Dubreuil, Bruno Bujoli, Daniel Talham
  • 2,9-dipyridyl-1,10-phenanthroline derivatives useful as actinide ligands, method for synthesizing same, and uses thereof
    Patent number: 9074266
    Abstract: The invention relates to novel compounds useful as ligands of actinides and which meet general formula (I) hereinafter: where: R1 and R2=H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; R3, R4, R5 and R6=H; a C1 to C12 hydrocarbon group; a monocyclic aryl or aryl-(C1 to C6)alkyl group; a —NR7R8 or —NR7COR8 group where R7=H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group, while R8=a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; an —OR9 or —SR9 group where R9=a C1 to C12 hydrocarbon group, a monocyclic C6 aryl or aryl-(C1 to C6)alkyl group. A further subject of the invention is a method for synthesizing these compounds and the uses thereof.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: July 7, 2015
    Assignees: Commissariat à l'énergie atomique et aux énergies alternatives, UNIVERSITE DE NANTES
    Inventors: Julia Bisson, Marie-Christine Charbonnel, Nathalie Boubals, Manuel Miguirditchian, Denis Guillaneux, Dominique Guillaumont, Cecile Marie, Didier Dubreuil, Muriel Pipelier, Virginie Blot
  • 2,9-DIPYRIDYL-1,10-PHENANTHROLINE DERIVATIVES USEFUL AS ACTINIDE LIGANDS, METHOD FOR SYNTHESIZING SAME, AND USES THEREOF
    Publication number: 20140030172
    Abstract: The invention relates to novel compounds useful as ligands of actinides and which meet general formula (I) hereinafter: where: R1 and R2?H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; R3, R4, R5 and R6?H; a C1 to C12 hydrocarbon group; a monocyclic aryl or aryl-(C1 to C6)alkyl group; a —NR7R8 or —NR7COR8 group where R7?H, a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group, whilst R8=a C1 to C12 hydrocarbon group, a monocyclic aryl or aryl-(C1 to C6)alkyl group; an —OR9 or —SR9 group where R9=a C1 to C12 hydrocarbon group, a monocyclic C6 aryl or aryl-(C1 to C6)alkyl group. A further subject of the invention is a method for synthesizing these compounds and the uses thereof.
    Type: Application
    Filed: March 28, 2012
    Publication date: January 30, 2014
    Applicants: UNIVERSITE DE NANTES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT
    Inventors: Julia Bisson, Marie-Christine Charbonnel, Nathalie Boubals, Manuel Miguirditchian, Denis Guillaneux, Dominique Guillaumont, Cecile Marie, Didier Dubreuil, Muriel Pipelier, Virginie Blot
  • ?-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
    Patent number: 8211859
    Abstract: The invention relates to ?-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the ?-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize ?-galactoceramide analogs by a mere metathesis reaction. The ?-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: July 3, 2012
    Assignees: Centre National de la Recherche Scientifique, Universite Paris Descartes, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Didier Dubreuil, Muriel Pipelier, Laurent Micouin, Thomas Lecourt, Vivien Lacone, Marc Bonneville, Jacques Lependu, Anne-Laure Turcot-Dubois
  • METHOD FOR MAKING BIOCHIPS
    Publication number: 20110118150
    Abstract: A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method. Also, a kit for the preparation of the chips.
    Type: Application
    Filed: July 15, 2010
    Publication date: May 19, 2011
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE NANTES, UNIVERSITY OF FLORIDA
    Inventors: Charles Tellier, Muriel Pipelier, Didier Dubreuil, Bruno Bujoli, Daniel Talham
  • ALPHA-GALACTOCERAMIDE ANALOGS, THEIR METHODS OF MANUFACTURE, INTERMEDIATE COMPOUNDS USEFUL IN THESE METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20110028411
    Abstract: The invention relates to ?-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the ?-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize ?-galactoceramide analogs by a mere metathesis reaction. The ?-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
    Type: Application
    Filed: October 18, 2007
    Publication date: February 3, 2011
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE
    Inventors: Didier Dubreuil, Muriel Pipelier, Laurent Micouin, Thomas Lecourt, Vivien Lacone, Marc Bonneville, Jacques Lependu, Anne-Laure Turcot-Dubois
  • Method for making biochips
    Patent number: 7795182
    Abstract: A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: September 14, 2010
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite de Nantes, University of Florida
    Inventors: Charles Tellier, Muriel Pipelier, Didier Dubreuil, Bruno Bujoli, Daniel Talham
  • Method for making biochips
    Publication number: 20060134717
    Abstract: A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.
    Type: Application
    Filed: July 22, 2003
    Publication date: June 22, 2006
    Inventors: Charles Tellier, Muriel Pipelier, Didier Dubreuil, Bruno Bujoli, Daniel Talham