Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.

Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.

Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.

Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.

Abstract: A method of directing an audio signal to an intended user by a remote-control device coupled to an audio/video device is described. The remote-control device sends an instruction to the audio/video device to transmit an audio signal. The remote-control device receives the audio signal and processes the audio signal to generate a directional audio. The directional audio is then routed to an intended user such that the directional audio signal is audible to the intended user, but not to other recipients in the vicinity.

Abstract: A method of directing an audio signal to an intended user by a remote-control device coupled to an audio/video device is described. The remote-control device sends an instruction to the audio/video device to transmit an audio signal. The remote-control device receives the audio signal and processes the audio signal to generate a directional audio. The directional audio is then routed to an intended user such that the directional audio signal is audible to the intended user, but not to other recipients in the vicinity.

Abstract: A method of directing an audio signal to an intended user by a remote-control device coupled to an audio/video device is described. The remote-control device sends an instruction to the audio/video device to transmit an audio signal. The remote-control device receives the audio signal and processes the audio signal to generate a directional audio. The directional audio is then routed to an intended user such that the directional audio signal is audible to the intended user, but not to other recipients in the vicinity.

Abstract: A method of directing an audio signal to an intended user by a remote-control device coupled to an audio/video device is described. The remote-control device sends an instruction to the audio/video device to transmit an audio signal. The remote-control device receives the audio signal and process the audio signal to generate a directional audio. The directional audio is then routed to an intended user such that the directional audio signal is audible to the intended user, other recipients in the vicinity.