Patents by Inventor Murli KRISHNA

Murli KRISHNA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using human FC-bearing IGG antibodies to polyethylene glycol
    Patent number: 10451634
    Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: October 22, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Murli Krishna, Alexander T. Kozhich, Martin J. Corbett, Zheng Lin, Steven P. Piccoli
  • HUMAN FC-BEARING IGG ANTIBODIES TO POLYETHYLENE GLYCOL
    Publication number: 20180038872
    Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.
    Type: Application
    Filed: September 29, 2017
    Publication date: February 8, 2018
    Inventors: Murli Krishna, Alexander T. Kozhich, Martin J. Corbett, Zheng Lin, Steven P. Piccoli
  • Antibodies to polyethylene glycol
    Patent number: 9804170
    Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 31, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Murli Krishna, Alexander T. Kozhich, Martin J. Corbett, Zheng Lin, Steven P. Piccoli
  • HUMAN FC-BEARING IGG ANTIBODIES TO POLYETHYLENE GLYCOL
    Publication number: 20160231328
    Abstract: Polyethylene glycol (PEG) is often conjugated with therapeutic proteins to enhance their PK properties. PEG may, however, be immunogenic, and the presence of PEG in food and cosmetics is believed to result in pre-existing anti-PEG antibodies in humans. Polyclonal and monoclonal antibodies reactive to PEG are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies exhibit preferential binding based on the size of PEG with molecular weight ranging from 350 daltons to 40 kD. Anti-PEG antibodies of the invention are engineered to comprise human Fc regions to enable non-bridging immunoassay formats.
    Type: Application
    Filed: February 8, 2016
    Publication date: August 11, 2016
    Inventors: Murli KRISHNA, Alexander T. Kozhich, Martin J. Corbett, Zheng Lin, Steven P. Piccoli