Abstract: A hypodermic syringe capable of pre-filling aseptically from either end. Both ends of the rimmed syringe barrel are sealed and capped with standard vaccine or syringe vial closures and crimped aluminum seals. Both ends of the pre-filled and sealed syringe maintain assured sterility integrity by guaranteed microbe-proof barriers during the entire shelf life of package or container. The syringe is prepared for use by simply removing protective caps or seals. The needle assembly is packaged separately and placed in position on syringe by a simple action.

Abstract: A pre-filled syringe-needle assembly in which the needle is covered with a shield-closure unit to assure sterility. Said shield-closure unit comprises a tube which covers the needle and a plug for said tube, one end of said tube being adapted for fitting tightly over the reduced part of the barrel of a syringe, and the other end being covered by the plug, both said end and plug covering it being adapted to provide an air-tight fit between them, said plug being sufficiently long to engage the tip of the needle inside the tube.