Patents by Inventor Murtaza Alibhai
Murtaza Alibhai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210371836Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: ApplicationFiled: March 17, 2021Publication date: December 2, 2021Inventors: Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth ARLAGADDA, Elizabeth CLARKE
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Patent number: 11021695Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: GrantFiled: April 20, 2018Date of Patent: June 1, 2021Assignee: Genomatica, Inc.Inventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
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Publication number: 20190093089Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: ApplicationFiled: April 20, 2018Publication date: March 28, 2019Inventors: Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth Arlagadda, Elizabeth CLARKE
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Patent number: 9951322Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: GrantFiled: February 22, 2017Date of Patent: April 24, 2018Assignee: REG Life Sciences, LLCInventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
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Publication number: 20170292121Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: ApplicationFiled: February 22, 2017Publication date: October 12, 2017Inventors: Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth Arlagadda, Elizabeth CLARKE
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Patent number: 9587231Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: GrantFiled: August 14, 2015Date of Patent: March 7, 2017Assignee: REG LIFE SCIENCES, LLCInventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
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Publication number: 20160046914Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: ApplicationFiled: August 14, 2015Publication date: February 18, 2016Inventors: Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth Arlagadda, Elizabeth CLARKE
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Patent number: 9175234Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: GrantFiled: December 23, 2009Date of Patent: November 3, 2015Assignee: REG Life Sciences, LLCInventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
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Patent number: 8183028Abstract: Compositions and methods for producing olefins are described herein. The olefins can be used to produced biofuels.Type: GrantFiled: December 22, 2008Date of Patent: May 22, 2012Assignee: LS9, Inc.Inventors: Murtaza Alibhai, Mathew Rude, Andreas Schirmer
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Publication number: 20110196180Abstract: Compositions and methods for producing olefins are described herein. The olefins can be used to produced biofuels.Type: ApplicationFiled: December 22, 2008Publication date: August 11, 2011Applicant: LS9, INC.Inventors: Murtaza Alibhai, Mathew Rude, Andreas Schirmer
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Publication number: 20100154293Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.Type: ApplicationFiled: December 23, 2009Publication date: June 24, 2010Inventors: Louis Hom, Na Trinh, Murtaza Alibhai
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Publication number: 20090044288Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting, of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait.Type: ApplicationFiled: July 18, 2008Publication date: February 12, 2009Inventors: Mark Abad, Murtaza Alibhai, Alice Clara Augustine, Amarjit Basra, Erin Bell, Terry L. Bradshaw, Paolo Castiglioni, Jaishree M. Chittoor-Vijayanath, Jill Deikman, Molian Deng, Michael D. Edgerton, Karen K. Gabbert, Barry S. Goldman, Balasulojini Karunanandaa, Susanne Kjemtrup-Lovelace, Timothy J. Leland, Adrian A. Lund, Linda Lutfiyya, Marcus McNabnay, Donald E. Nelson, Thomas G. Ruff, Beth Savidge, Paul Schaffer, Padmini Sudarshana, K. Sumathy, Carolyn Thai, Rebecca L. Thompson-Mize, Carl P. Urwin, H.G. Veena, T.V. Venkatesh, Steven T. Voss, Zhidong Xie
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Publication number: 20080010700Abstract: Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed to generally contribute to the allergenic properties of patatin proteins. Removal of glycosylation sites was observed to reduce or eliminate antibody binding. Permuteins are also disclosed which have a rearranged amino acid sequence while retaining enzymatic activity. Deallergenized proteins and permuteins can be used as insecticidal materials, as nutritional supplements, and as immunotherapeutic agents.Type: ApplicationFiled: June 28, 2007Publication date: January 10, 2008Inventors: Murtaza Alibhai, James Astwood, Charles McWherter, Hugh Sampson
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Publication number: 20060206962Abstract: Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed to generally contribute to the allergenic properties of patatin proteins. Removal of glycosylation sites was observed to reduce or eliminate antibody binding. Permuteins are also disclosed which have a rearranged amino acid sequence while retaining enzymatic activity. Deallergenized proteins and permuteins can be used as insecticidal materials, as nutritional supplements, and as immunotherapeutic agents.Type: ApplicationFiled: September 7, 2005Publication date: September 14, 2006Inventors: Murtaza Alibhai, James Astwood, Charles McWherter, Hugh Sampson
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Publication number: 20060143727Abstract: The compositions and methods disclosed herein provide novel DNA molecules that encode glyphosate resistant EPSPS proteins and plants containing these new proteins. The plants that express the new EPSPS proteins are themselves tolerant to the herbicidal effects of glyphosate.Type: ApplicationFiled: February 17, 2004Publication date: June 29, 2006Applicant: MONSANTO TECHNOLOGY LLCInventors: Murtaza Alibhai, Claire Cajacob, Paul Feng, Gregory Heck, Youlin Qi, Stanislaw Flasinski, William Stallings