Abstract: Various examples are provided related to methods and systems to reconstruct 3D image/map for the stiffness of soft tissues. In one example, a method includes obtaining particle velocities from generated mechanical waves in tissue of a subject; reconstructing a stiffness map of soft tissue in a region of interest (ROI) from the particle velocities; and generating an image of the stiffness map for rendering on a user device. In another example, a system includes an ultrasound scanner for shear wave elastography (SWE) and a computing or processing device that can obtain particle velocities; reconstruct a stiffness map of soft tissue in a ROI from the particle velocities; and generate an image of the stiffness map for rendering. The particle velocities can be generated from acoustic radiation forces produced by the ultrasound scanner.

Abstract: Various examples are provided related to estimation of viscoelasticity of an arterial or venous wall. In one example, a method includes obtaining ultrasound data of an arterial or venous wall for a defined acoustic radiation force; and determining viscoelasticity of the arterial or venous wall. The viscoelasticity can be determined based upon correlation between measured and simulated wall velocity of the ultrasound data in a space-time, a wavenumber-frequency, wavenumber-time, or space-frequency domain; or in a sequential manner by determining the elastic part of the modulus by matching measured and simulated phase velocities and determining the viscoelasticity part by matching measured and simulated wall velocities; or a combination of both. The simulated velocity can be determined for a wall thickness and viscoelastic modulus of the arterial or venous wall through full wave analysis. In another example, a system includes an ultrasound scanner and a computing device that can implement the method.