Patents by Inventor Murthy V. S. N. Yerramilli

Murthy V. S. N. Yerramilli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the detection and diagnosis of renal disease and periodontal disease
    Patent number: 12385927
    Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: August 12, 2025
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Giosi Farace, John J. Quinn, Murthy V. S. N. Yerramilli
  • Method for removing interfering components of a liquid sample prior to dispensing same on a chemical reagent test slide
    Patent number: 12366506
    Abstract: A method using a chemical analyzer for removing a component of a liquid sample which may interfere with a test performed on a test assay includes the steps of adding the liquid sample to a sample cup, transferring a volume of the liquid sample to a mixing cup containing an IMAC (Immobilized Metal Affinity Chromatography) resin containing porous beads to form a sample/resin solution in the mixing cup, using a pipette of the chemical analyzer to repeatedly aspirate the sample/resin solution into a disposable pipette tip of the pipette and expelling the sample/resin solution from the pipette tip into the mixing cup to achieve a mixed sample/resin solution in the mixing cup, and allowing the mixed sample/resin solution in the mixing cup to rest undisturbed so that the interfering component of the liquid sample adheres to the porous beads and the beads settle to a bottom portion of the mixing cup, resulting in a refined liquid sample devoid of the interfering component and occupying an upper portion of the mixing
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: July 22, 2025
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Pamela Ann Cacavas, Lucius S. Fox, Robert W. Lachapelle, Wendy O'Malley LePage, Evan M. Peck, Dominic Pelletier, Eric Allen Steva, Murthy V. S. N. Yerramilli
  • Fluorescence quenching immunoassay
    Patent number: 12345641
    Abstract: The present invention relates to a method and reagents for determining the presence of or the amount of an analyte in a sample.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: July 1, 2025
    Assignee: IDEZZ Laboratories, Inc.
    Inventors: Jennifer E. Gagner, Kiamars Hajizadeh, Evan M. Peck, James R. Salter, Paul J. Travers, Christopher P. Turmel, Yingzi Wu, Hongzhi Xie, Murthy V. S. N. Yerramilli
  • Markers for renal disease
    Patent number: 12241900
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Grant
    Filed: February 5, 2024
    Date of Patent: March 4, 2025
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshimi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
  • Markers for renal disease
    Patent number: 11933792
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Grant
    Filed: July 28, 2022
    Date of Patent: March 19, 2024
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshimi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
  • Markers for renal disease
    Patent number: 11435365
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: September 6, 2022
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
  • Methods and compositions for the detection and diagnosis of renal disease and periodontal disease
    Patent number: 10725052
    Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: July 28, 2020
    Assignee: IDEXX LABORATORIES, INC.
    Inventors: Mahalakshmi Yerramilli, Giosi Farace, John J. Quinn, Murthy V. S. N. Yerramilli
  • Markers for renal disease
    Patent number: 10436797
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: October 8, 2019
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
  • Methods for detecting symmetrical dimethylarginine
    Patent number: 9970927
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: May 15, 2018
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Murthy V. S. N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
  • Methods for detecting symmetrical dimethylarginine
    Patent number: 9091684
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: July 28, 2015
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Murthy V. S. N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
  • Detection of degradation products of canine NT-proBNP
    Patent number: 8778699
    Abstract: A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits and device.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: July 15, 2014
    Assignee: Idexx Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V. S. N. Yerramilli
  • Detection of degradation products of feline NT-proBNP
    Patent number: 8481333
    Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: July 9, 2013
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V. S. N. Yerramilli
  • Phospholipid gel compositions for drug delivery and methods of treating conditions using same
    Patent number: 8361496
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: January 29, 2013
    Assignee: Idexx Laboratories Inc.
    Inventor: Murthy V. S. N. Yerramilli