Abstract: In various embodiments, a compensator can be attachable to an anvil of a fastening instrument. The compensator can comprise a support layer configured to be attached to the anvil and a scaffold attached to the support layer. In at least one embodiment, the scaffold can comprise a plurality of scaffold layers comprised of a biocompatible material and a plurality of cavities, wherein the layers and the cavities can define a matrix favorable to tissue and cellular ingrowth.

Abstract: In various embodiments, a compensator can be attachable to an anvil of a fastening instrument. The compensator can comprise a support layer configured to be attached to the anvil and a scaffold attached to the support layer. In at least one embodiment, the scaffold can comprise a plurality of scaffold layers comprised of a biocompatible material and a plurality of cavities, wherein the layers and the cavities can define a matrix favorable to tissue and cellular ingrowth.

Abstract: A staple cartridge for stapling the tissue of a patient is disclosed. The staple cartridge comprises a cartridge body, a plurality of staples, and a compressible tissue thickness compensator configured to adapt in thickness in response to the thickness of the tissue and adaptively apply different pressures to the tissue based on the thickness of the tissue captured within the staples. The compressible tissue thickness compensator comprises a plurality of fibers comprising a first matrix oriented in a first direction and a second matrix oriented in a second direction that is different than the first direction. A network of interstices is defined intermediate and among the first matrix and the second matrix. The network of interstices comprises a plurality of cavities that promote tissue and cellular ingrowth between the first and second matrices of fibers.

Abstract: An implant having an adhesive structure comprising a planar surface having two sides and rectangular cuboid-based protrusions having pyramidal tips extending from at least one of said sides, optionally having a porous basic supporting structure, and methods of making and using such implants.

Abstract: A stapling system for stapling tissue is disclosed. The stapling system comprises a cartridge body, staples removably stored in the cartridge body, and an implantable layer. The implantable layer comprises a first portion comprising a first density, wherein the first portion is comprised of a material. The implantable layer further comprises a lattice comprising a second density, wherein the first density is different than the second density, and wherein the lattice is comprised of the material. The implantable layer further comprises a medicament which promotes tissue ingrowth into the layer in a specified pattern.

Abstract: In various embodiments, a compensator can be attachable to an anvil of a fastening instrument. The compensator can comprise a support layer configured to be attached to the anvil and a scaffold attached to the support layer. In at least one embodiment, the scaffold can comprise a plurality of scaffold layers comprised of a biocompatible material and a plurality of cavities, wherein the layers and the cavities can define a matrix favorable to tissue and cellular ingrowth.

Abstract: A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

Abstract: In various embodiments, a compensator can be attachable to an anvil of a fastening instrument. The compensator can comprise a support layer configured to be attached to the anvil and a scaffold attached to the support layer. In at least one embodiment, the scaffold can comprise a plurality of scaffold layers comprised of a biocompatible material and a plurality of cavities, wherein the layers and the cavities can define a matrix favorable to tissue and cellular ingrowth.

Abstract: A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.

Abstract: A method of separating blood by providing a horizontal substrate having a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film, depositing a whole blood sample on an upper surface of the substrate, collecting red blood cells on the upper surface of the pillars and permitting remaining components of said whole blood sample to flow downward and through the pillars.

Abstract: A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.

Abstract: In various embodiments, a compensator can be attachable to an anvil of a fastening instrument. The compensator can comprise a support layer configured to be attached to the anvil and a scaffold attached to the support layer. In at least one embodiment, the scaffold can comprise a plurality of scaffold layers comprised of a biocompatible material and a plurality of cavities, wherein the layers and the cavities can define a matrix favorable to tissue and cellular ingrowth.

Abstract: The present invention relates to a medical device for placement at a predetermined location within a passageway of the human body, and more particularly, relates to a flexible embolization device which may be delivered by a catheter to a pre-selected position within a blood vessel to thereby embolize a blood vessel or a blood vessel defect, such as an aneurysm or fistula. Specifically, the embolization device comprises an elongated coil having a lumen, the coil and lumen being at least partially embedded in an elongated foam member comprising, in some embodiments, a flexible, biodegradable, water insoluble, open, interconnecting-cell foam material having embolic characteristics, and capable of allowing cell proliferation into the open cell foam interior.

Abstract: A vascular embolization device comprises an elongated coil having a lumen, said coil and lumen being at least partially embedded in an elongated foam member comprising a flexible, biodegradable, water insoluble, open, interconnecting-cell foam material having embolic characteristics, and capable of allowing cell proliferation into the open cell foam interior. A manufacturing method is disclosed.

Abstract: The present invention relates to a medical device for placement at a predetermined location within a passageway of the human body, and more particularly, relates to a flexible embolization device which may be delivered by a catheter to a pre-selected position within a blood vessel to thereby embolize a blood vessel or a blood vessel defect, such as an aneurysm or fistula. Specifically, the embolization device comprises an elongated coil having a lumen, the coil and lumen being at least partially embedded in an elongated foam member comprising, in some embodiments, a flexible, biodegradable, water insoluble, open, interconnecting-cell foam material having embolic characteristics, and capable of allowing cell proliferation into the open cell foam interior.