Patents by Inventor Mustafa H. Ghanem

Mustafa H. Ghanem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric antigen receptors to control HIV infection
    Patent number: 10246505
    Abstract: The present disclosure is directed to novel multispecific chimeric antigen receptor (CAR) proteins and DNA sequences encoding these proteins. The CARs comprise at least two extracellular domains fused, via a transmembrane domain to a cytoplasmic signaling domain comprising two signaling domains. The disclosure further relates to nucleic acids encoding the novel CARs, to host cells expressing the novel CARs, and to methods of using the CARs to co-stimulate effector functions in the cells and for using cells expressing the receptors for treatment of disease and viral infections. The disclosure also relates to methods of generating a recombinant T cell with reduced susceptibility to HIV infection.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: April 2, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Edward A. Berger, Mustafa H. Ghanem, Barna Dey
  • CHIMERIC ANTIGEN RECEPTORS TO CONTROL HIV INFECTION
    Publication number: 20170267739
    Abstract: The present disclosure is directed to novel multispecific chimeric antigen receptor (CAR) proteins and DNA sequences encoding these proteins. The CARs comprise at least two extracellular domains fused, via a transmembrane domain to a cytoplasmic signaling domain comprising two signaling domains. The disclosure further relates to nucleic acids encoding the novel CARs, to host cells expressing the novel CARs, and to methods of using the CARs to co-stimulate effector functions in the cells and for using cells expressing the receptors for treatment of disease and viral infections. The disclosure also relates to methods of generating a recombinant T cell with reduced susceptibility to HIV infection.
    Type: Application
    Filed: November 25, 2014
    Publication date: September 21, 2017
    Applicants: Health and Human Services
    Inventors: Edward A. Berger, Li Liu, Bhavik Patel, Steven A. Rosenberg, Richard A. Morgan, Mustafa H. Ghanem, Barna Dey