Patents by Inventor Mustafa N. Yazicioglu

Mustafa N. Yazicioglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SECRETABLE PROTEIN INDUCED IMMUNE TOLERIZATION AND TREATMENT OF AUTOIMMUNE, ALLERGIC AND OTHER DISEASES AND DISORDERS
    Publication number: 20230040275
    Abstract: Nucleic acids encoding fusion proteins that contain an unwanted antigen and a leader sequence for cell secretion are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat autoimmune, allergic and other diseases and disorders, such as multiple sclerosis.
    Type: Application
    Filed: November 19, 2020
    Publication date: February 9, 2023
    Applicant: SPARK THERAPEUTICS, INC.
    Inventors: David William ANDERSON, Brittney L. GURDA, Federico MINGOZZI, Mustafa N. YAZICIOGLU, William QUINN
  • Composition and methods for highly efficient gene transfer using AAV capsid variants
    Patent number: 11279950
    Abstract: Compositions and methods for AAV mediated gene therapy are disclosed. AAV vectors comprise protein capsid variants comprising therapeutically beneficial transgenes. AAV variants are provided which exhibit increased transduction efficiency when compared to AAV serotypes (e.g., AAV1, AAV2, AAV8, AAV-rh74), which lack the modifications disclosed herein. Such improved vectors are useful for transduction of a variety of tissues.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 22, 2022
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Mustafa N. Yazicioglu, Federico Mingozzi, Xavier Anguela, Katherine A. High
  • ENGINEERED AAV CAPSIDS WITH INCREASED TROPISM AND AAV VECTORS COMPRISING THE ENGINEERED CAPSIDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20210363192
    Abstract: The invention provides modified adeno-associated virus (AAV) capsid proteins. Modified AAV capsid proteins include, for example, capsid proteins modified to have a peptide insertion comprising a nuclear localization signal (NLS) sequence, capsid proteins modified to have an amino acid substitution at an RXXL site or a (L/P)PXY site, where X can be any amino acid, and capsid proteins modified to have one or more particular amino acid positions substituted with a different amino acid.
    Type: Application
    Filed: April 26, 2019
    Publication date: November 25, 2021
    Applicant: SPARK THERAPEUTICS, INC.
    Inventors: Xavier ANGUELA, Sean ARMOUR, Nicholas KEISER, Suryanarayan SOMANATHAN, Mustafa N. YAZICIOGLU
  • COMPOSITION AND METHODS FOR HIGHLY EFFICIENT GENE TRANSFER USING AAV CAPSID VARIANTS
    Publication number: 20180245098
    Abstract: Compositions and methods for AAV mediated gene therapy are disclosed. AAV vectors comprise protein capsid variants comprising therapeutically beneficial transgenes. AAV variants are provided which exhibit increased transduction efficiency when compared to AAV serotypes (e.g., AAV1, AAV2, AAV8, AAV-rh74), which lack the modifications disclosed herein. Such improved vectors are useful for transduction of a variety of tissues.
    Type: Application
    Filed: February 2, 2018
    Publication date: August 30, 2018
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Mustafa N. Yazicioglu, Federico Mingozzi, Xavier Aaguela, Katherine A. High
  • Composition and methods for highly efficient gene transfer using AAV capsid variants
    Patent number: 9909142
    Abstract: Compositions and methods for AAV mediated gene therapy are disclosed. AAV vectors comprise protein capsid variants comprising therapeutically beneficial transgenes. AAV variants are provided which exhibit increased transduction efficiency when compared to AAV serotypes (e.g., AAV1, AAV2, AAV8, AAV-rh74), which lack the modifications disclosed herein. Such improved vectors are useful for transduction of a variety of tissues.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: March 6, 2018
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Mustafa N. Yazicioglu, Federico Mingozzi, Xavier Anguela, Katherine A. High
  • COMPOSITION AND METHODS FOR HIGHLY EFFICIENT GENE TRANSFER USING AAV CAPSID VARIANTS
    Publication number: 20150065562
    Abstract: Improved compositions and methods for AAV mediated gene therapy are disclosed.
    Type: Application
    Filed: April 18, 2013
    Publication date: March 5, 2015
    Inventors: Mustafa N. Yazicioglu, Federico Mingozzi, Xavier Aaguela, Katherine A. High