Patents by Inventor Mustafa Vali

Mustafa Vali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
    Patent number: 10130598
    Abstract: The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: November 20, 2018
    Assignee: The Johns Hopkins University
    Inventors: Jean-Francois Geschwind, Mustafa Vali
  • Methods and Compositions for Administration of 3-Halopyruvate and Related Compounds for the Treatment of Cancer
    Publication number: 20170224641
    Abstract: The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
    Type: Application
    Filed: October 3, 2016
    Publication date: August 10, 2017
    Inventors: Jejan-Francois Geschwind, Mustafa Vali
  • Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
    Patent number: 9492417
    Abstract: The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: November 15, 2016
    Assignee: The Johns Hopkins University
    Inventors: Jean-Francois Geschwind, Mustafa Vali
  • METHODS OF TREATMENT USING 3-BROMOPYRUVATE AND OTHER SELECTIVE INHIBITORS OF ATP PRODUCTION
    Publication number: 20150359764
    Abstract: The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.
    Type: Application
    Filed: August 26, 2015
    Publication date: December 17, 2015
    Inventors: Jean-Francois Geschwind, Mustafa Vali
  • Therapeutics for Cancer Using 3-Bromopyruvate and Other Selective Inhibitors of ATP Production
    Publication number: 20100203110
    Abstract: The present invention relates to methods of treating a cancerous tumor in a subject comprising administering to the subject an effective amount of 3-bromopyruvate. The 3-bromopyruvate may be administered intraarterially directly to a tumor as a continuous intraarterial infusion. The present invention also relates to methods for identifying agents that inhibit type II hexokinase activity.
    Type: Application
    Filed: December 17, 2007
    Publication date: August 12, 2010
    Applicant: The Johns Hopkins University
    Inventors: Jean-Francois Geschwind, Mustafa Vali
  • Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
    Publication number: 20100137434
    Abstract: The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
    Type: Application
    Filed: August 21, 2009
    Publication date: June 3, 2010
    Inventors: Jean-Francois Geschwind, Mustafa Vali