Patents by Inventor Mustafa Varoglu

Mustafa Varoglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
    Publication number: 20240301406
    Abstract: The invention relates to methods for treating subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria, using iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and anti-C5 antibodies, e.g., eculizumab.
    Type: Application
    Filed: July 6, 2023
    Publication date: September 12, 2024
    Inventors: Nader Najafian, Jae Kim, Mustafa Varoglu, Gabriel Robbie
  • COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
    Publication number: 20210171946
    Abstract: The invention relates to methods for treating subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria, using iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and anti-C5 antibodies, e.g., eculizumab.
    Type: Application
    Filed: October 14, 2020
    Publication date: June 10, 2021
    Inventors: Nader Najafian, Jae Kim, Mustafa Varoglu, Gabriel Robbie
  • COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
    Publication number: 20190256845
    Abstract: The invention relates to methods for treating subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria, using iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and anti-C5 antibodies, e.g., eculizumab.
    Type: Application
    Filed: June 9, 2017
    Publication date: August 22, 2019
    Inventors: Nader Najafian, Jae Kim, Mustafa Varoglu, Gabriel Robbie
  • Mitomycin biosynthetic gene cluster
    Publication number: 20030134398
    Abstract: The invention provides a biosynthetic gene cluster for mitomycin, as well as methods of using gene(s) within the cluster to alter biosynthesis.
    Type: Application
    Filed: September 12, 2001
    Publication date: July 17, 2003
    Inventors: David H. Sherman, Yingqing Mao, Mustafa Varoglu, Min He, Paul Sheldon
  • Glycosylated kinamycins and methods of making and using them
    Publication number: 20030124679
    Abstract: The invention provides compositions, including pharmaceuticals, comprising glycosylated kinamycins. The compositions and methods of the invention can be used to treat infections, i.e., as antibiotics, and as anti-tumor agents. The compositions of the invention can also act as act as electrophilic azo-coupling agents in vitro or in vivo. The invention also provides enzymes capable of generating kinamycin, nucleic acids that encode them, antibodies that bind to them, and methods for making and using them.
    Type: Application
    Filed: June 27, 2002
    Publication date: July 3, 2003
    Inventors: Jay M. Short, Ashish Paradkar, Mustafa Varoglu, Eric J. Mathur
  • Mitomycin biosynthetic gene cluster
    Publication number: 20030124689
    Abstract: The invention provides a biosynthetic gene cluster for mitomycin, as well as methods of using gene(s) within the cluster to alter biosynthesis.
    Type: Application
    Filed: October 9, 2002
    Publication date: July 3, 2003
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Yingqing Mao, Mustafa Varoglu, Min He, Paul Sheldon
  • Mitomycin biosynthetic gene cluster
    Patent number: 6495348
    Abstract: The invention provides a biosynthetic gene cluster for mitomycin, for example, a mitomycin biosynthetic cluster from organisms such as Streptomyces, for instance, S. lavendulae, as well as methods of using gene(s) within the cluster to alter antibiotic biosynthesis and to prepare a polyketide synthase.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: December 17, 2002
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Sherman, Yingqing Mao, Mustafa Varoglu, Min He, Paul Sheldon