Patents by Inventor Mustafa Yazicioglu

Mustafa Yazicioglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF REGULATING ADENO-ASSOCIATED VIRUS PRODUCTION
    Publication number: 20240101972
    Abstract: The presently disclosed subject matter relates to compositions and methods for regulating recombinant adeno-associated virus (rAAV) production in cell culture. In particular, the presently disclosed subject matter relates to strategies to overcome AAV Rep protein-mediated cytotoxicity by reversible post-translational regulation of the expression of AAV Rep and helper proteins, resulting in regulated rAAV production.
    Type: Application
    Filed: December 11, 2023
    Publication date: March 28, 2024
    Applicant: SPARK THERAPEUTICS, INC.
    Inventors: Mustafa Yazicioglu, Ahmet Yunus Ozdemir
  • Variant AAV and Compositions, Methods and Uses for Gene Transfer to Cells, Organs and Tissues
    Publication number: 20180187213
    Abstract: The invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and AAV-Rh74 and related AAV vector mediated gene transfer methods and uses. In particular, AAV-Rh74 and related AAV vectors target polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences.
    Type: Application
    Filed: December 6, 2017
    Publication date: July 5, 2018
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Katherine A. High, Mustafa Yazicioglu, Xavier Anguela
  • Variant AAV and compositions, methods and uses for gene transfer to cells, organs and tissues
    Patent number: 9840719
    Abstract: The invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and AAV-Rh74 and related AAV vector mediated gene transfer methods and uses. In particular, AAV-Rh74 and related AAV vectors target polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: December 12, 2017
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Katherine High, Mustafa Yazicioglu, Xavier Anguela
  • VARIANT AAV AND COMPOSITIONS, METHODS AND USES FOR GENE TRANSFER TO CELLS, ORGANS AND TISSUES
    Publication number: 20150023924
    Abstract: The invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and AAV-Rh74 and related AAV vector mediated gene transfer methods and uses. In particular, AAV-Rh74 and related AAV vectors target polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences.
    Type: Application
    Filed: July 22, 2014
    Publication date: January 22, 2015
    Inventors: Katherine High, Mustafa Yazicioglu, Xavier Anguela