Patents by Inventor Mustapha Haddach

Mustapha Haddach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Compositions, Uses and Methods for Making Them
    Publication number: 20160326176
    Abstract: Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: May 9, 2015
    Publication date: November 10, 2016
    Inventor: Mustapha Haddach
  • NOVEL COMPOSITIONS, USES AND METHODS FOR MAKING THEM
    Publication number: 20160257678
    Abstract: Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: November 6, 2015
    Publication date: September 8, 2016
    Inventor: Mustapha Haddach
  • Pyrazolopyrimidines and related heterocycles as CK2 inhibitors
    Patent number: 9303033
    Abstract: The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: April 5, 2016
    Assignee: SENHWA BIOSCIENCES, INC.
    Inventors: Mustapha Haddach, Joe A. Tran, Fabrice Pierre, Collin F. Regan, Nicholas Raffaele, Suchitra Ravula, David M. Ryckman
  • Quinolone analogs and methods related thereto
    Patent number: 8853234
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: October 7, 2014
    Assignee: Senhwa Biosciences, Inc.
    Inventors: Johnny Yasuo Nagasawa, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • 5-lipoxygenase-activating protein (FLAP) inhibitors
    Patent number: 8841295
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: September 23, 2014
    Assignee: Panmira Pharmaceuticals, LLC
    Inventors: John H. Hutchinson, Yiwei Li, Mustapha Haddach, Nicholas Simon Stock
  • PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS
    Publication number: 20140094448
    Abstract: The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds.
    Type: Application
    Filed: September 13, 2013
    Publication date: April 3, 2014
    Applicant: SENHWA BIOSCIENCES, INC.
    Inventors: Mustapha Haddach, Joe A. Tran, Fabrice Pierre, Collin F. Regan, Nicholas Raffaele, Suchitra Ravula, David M. Ryckman
  • Pyrazolopyrimidines and related heterocycles as CK2 inhibitors
    Patent number: 8575177
    Abstract: The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: November 5, 2013
    Assignee: Senhwa Biosciences, Inc.
    Inventors: Mustapha Haddach, Joe A. Tran, Fabrice Pierre, Collin F. Regan, Nicholas B. Raffaele, Suchitra Ravula, David M. Ryckman
  • 5-lipoxygenase-activating protein (FLAP) inhibitors
    Patent number: 8399666
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: March 19, 2013
    Assignee: Panmira Pharmaceuticals, LLC
    Inventors: John H. Hutchinson, Petpiboon Peppi Prasit, Mark Moran, Jillian F. Evans, Brian Andrew Stearns, Jeffrey Roger Roppe, Yiwei Li, Jasmine Eleanor Zunic, Jeannie M. Arruda, Nicholas Simon Stock, Mustapha Haddach
  • Pyrazolopyrimidines and related heterocycles as kinase inhibitors
    Patent number: 8367681
    Abstract: The invention provides compounds of general formula (I) that inhibit selected kinases (Pim and/or CK2 kinases) and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain infections and immunological disorders.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: February 5, 2013
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Mustapha Haddach, Joe Tran
  • PROTEIN KINASE MODULATORS
    Publication number: 20120208792
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
    Type: Application
    Filed: December 8, 2011
    Publication date: August 16, 2012
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Peter C. Chua, Mustapha Haddach, Johnny Y. Nagasawa, Fabrice Pierre, Jeffrey P. Whitten
  • OXINDOLE COMPOUNDS
    Publication number: 20120190669
    Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
    Type: Application
    Filed: January 20, 2012
    Publication date: July 26, 2012
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Mustapha Haddach, Johnny Yasuo Nagasawa
  • DEUTERATED SERINE-THREONINE PROTEIN KINASE MODULATORS
    Publication number: 20120129849
    Abstract: The present invention provides deuterated compounds having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. The deuterated compounds of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such deuterated compounds as therapeutic agents.
    Type: Application
    Filed: September 23, 2011
    Publication date: May 24, 2012
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Mustapha HADDACH, David M. Ryckman
  • Protein kinase modulators
    Patent number: 8168651
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: May 1, 2012
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. Chua, Mustapha Haddach, Johnny Y. Nagasawa, Fabrice Pierre, Jeffrey P. Whitten
  • Oxindole compounds
    Patent number: 8124649
    Abstract: The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 28, 2012
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Mustapha Haddach, Johnny Yasuo Nagasawa
  • QUINOLONE ANALOGS AND METHODS RELATED THERETO
    Publication number: 20110218184
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 8, 2011
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Johnny Yasuo NAGASAWA, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten
  • 5-lipdxygenase-activating protein (FLAP) inhibitors
    Patent number: 7977359
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: July 12, 2011
    Assignee: Amira Pharmaceuticals, Inc.
    Inventors: John H. Hutchinson, Petpiboon Peppi Prasit, Mark Moran, Jillian F. Evans, Brian Andrew Stearns, Jeffrey Roger Roppe, Yiwei Li, Jasmine Eleanor Zunic, Jeannie M. Arruda, Nicholas Simon Stock, Mustapha Haddach
  • Methods and compounds for treating retinol-related diseases
    Patent number: 7973079
    Abstract: Compounds that reduce serum retinol levels are used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods, compounds, and compositions to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: July 5, 2011
    Assignee: Revision Therapeutics, Inc.
    Inventors: Nathan L. Mata, Kim B. Phan, Tam V. Bui, Mustapha Haddach
  • PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS
    Publication number: 20110152240
    Abstract: The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds.
    Type: Application
    Filed: November 15, 2010
    Publication date: June 23, 2011
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Mustapha Haddach, Joe A. Tran, Fabrice Pierre, Collin F. Regan, Nicholas B. Raffaele, Suchitra Ravula, David M. Ryckman
  • 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS
    Publication number: 20110118315
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Inventors: John H. Hutchinson, Petpiboon Peppi Prasit, Mark Moran, Jillian F. Evans, Yiwei Li, Jasmine Eleanor Zunic, Jeannie M. Arruda, Nicholas Simon Stock, Brian Andrew Stearns, Mustapha Haddach, Jeffrey Roger Roppe
  • Quinolone analogs and methods related thereto
    Patent number: 7928100
    Abstract: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: April 19, 2011
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Johnny Yasuo Nagasawa, Fabrice Pierre, Mustapha Haddach, Michael Schwaebe, Levan Darjania, Jeffrey P. Whitten