Patents by Inventor Muthusamy Kunnimalaiyaan

Muthusamy Kunnimalaiyaan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulating notch1 signaling pathway for treating neuroendocrine tumors
    Patent number: 8338482
    Abstract: Methods and pharmaceutical compositions for treating or suppressing symptoms of neuroendocrine (NE) tumors comprising increasing the levels or activities of Notch1 protein or other components of the Notch1 signaling pathway of the cancer cells. Also disclosed are pharmaceutical compositions for the methods.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: December 25, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Herbert Chen, Muthusamy Kunnimalaiyaan
  • Modulating Notch1 Signaling Pathway for Treating Neuroendocrine Tumors
    Publication number: 20080045445
    Abstract: Methods and pharmaceutical compositions for treating or suppressing symptoms of neuroendocrine (NE) tumors comprising increasing the levels or activities of Notch1 protein or other components of the Notch1 signaling pathway of the cancer cells. Also disclosed are pharmaceutical compositions for the methods.
    Type: Application
    Filed: July 20, 2007
    Publication date: February 21, 2008
    Inventors: Herbert Chen, Muthusamy Kunnimalaiyaan
  • Compositions and methods for treating neuroendocrine tumors
    Publication number: 20060121040
    Abstract: Methods and pharmaceutical compostions for treating or suppressing symptoms of neuroendocrine (NE) tumors comprising inhibiting the activities of GSK-3? of the cancer cells. Also disclosed are pharmaceutical compositions for the methods. Preferably, the pharmaceutical composition comprises Li+, SB216763, SB415286, indirubins, Paullones, Hymenialdisine, Azakenpaullone, Thienyl and phenyl ?-halomethyl ketones, CHR 99021, AR-A014418, Bis-7-azaindolylmaleimides, CHR 98023, CHR-98014, and ZM336372, or a pharmaceutically acceptable salt or derivative thereof.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 8, 2006
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Muthusamy Kunnimalaiyaan, Herbert Chen