Abstract: A method of manufacturing a thick, high-strength steel pipe for low temperature service comprising the steps of forming into tubular shape a steel plate having a thickness of over 12 mm and a specific composition, of which the C.sub.eq value is adjusted to less than 0.50, when the Mn content is less than 1.0 % whereas the C.sub.eq value is adjusted to less than 0.45 when the Mn content is over 1.0 % and less than 2.0 %, and nextly of welding said tube form at high speeds and high efficiency by the process of single electrode or multiple electrode large-current gas-shielded arc welding with one pass per electrode on each side of the seam at a specific condition, each electrode preferably consisting of a solid wire essentially containing less than 0.3 % Ti with or without the addition of less than 0.