Patents by Inventor Muxiang Zhou

Muxiang Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUINOLINE DERIVATIVES AND USES IN MANAGING CANCER
    Publication number: 20240059658
    Abstract: Provided herein are compounds, pharmaceutical compositions including such compounds, and methods of using such compounds to treat diseases or disorders associated with MDM2 activity.
    Type: Application
    Filed: September 10, 2020
    Publication date: February 22, 2024
    Inventors: Muxiang Zhou, Lubing Gu, We Li, Zhongzhi Wu
  • Anthraquinone analogs and methods of making and using thereof
    Patent number: 10544090
    Abstract: Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: January 28, 2020
    Assignees: Georgia State University Research Foundation, Inc., Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Binghe Wang, Chaofeng Dai, Alexander Draganov, Xiaochuan Yang, Guojing Sun, Chunhao Yang, Weixuan Chen, Nanting Ni, Muxiang Zhou, Lubing Gu
  • Anthraquinone Analogs and Methods of Making and Using Thereof
    Publication number: 20150203442
    Abstract: Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.
    Type: Application
    Filed: July 10, 2013
    Publication date: July 23, 2015
    Inventors: Binghe Wang, Chaofeng Dai, Alexander Draganov, Xiaochuan Yang, Guojing Sun, Chunhao Yang, Weixuan Chen, Nanting Ni, Muxiang Zhou, Lubing Gu