Abstract: The present invention provides an electrospray ionization source, which includes: a capillary, including a spray tip; a first electrode which provides the spray tip with a spray voltage; and a second electrode. The electrical potential difference between the first electrode and the second electrode forms a separation electric field, which allows the electric field separation and electrospray ionization of the sample to be accomplished simultaneously, thereby improving the sensitivity of detection.

Abstract: The present invention provides a mobility electrophoresis separation device, its operating method, and an interface between liquid chromatography and mass spectrometry. The mobility electrophoresis separation device comprises a separation capillary, a syringe pump for injecting a buffer solution, a syringe for injecting a sample solution, and two electrodes disposed apart from each other on either side of the separation capillary. A sample solution is injected by a syringe at a position of the capillary channel, and a buffer solution is injected into the capillary channel upstream the first position, and carries the sample solution to flow downstream. While the mixed liquid flows through the capillary, an electric field is applied in the direction of the flow. Different ions in the sample are thus separated in the flow due to their different velocities traveling in the flow.

Abstract: A method for analyzing ionic structure, including: applying a radio frequency electric field on an ion mass analyzer to cause sample ions to be excited to a motion amplitude, the motion amplitude at this moment being recorded as a primary motion amplitude; continuously feeding carrier gas into the ion mass analyzer and keeping a certain degree of vacuum in the ion mass analyzer, the sample ions being collided with the carrier gas and the motion amplitude being decreased gradually, and collecting a time domain signal of an image current generated by the sample ions during the process; and analyzing the time domain signal through a time-frequency analysis method and obtaining time-varying characteristic curves indicating corresponding relations between the motion frequencies of the ions having corresponding sizes and the collision cross sectional areas of the ions and the carrier gas, thus distinguishing among ions having different sizes.

Abstract: The present invention provides an electrospray ionization source, which includes: a capillary, including a spray tip; a first electrode which provides the spray tip with a spray voltage; and a second electrode. The electrical potential difference between the first electrode and the second electrode forms a separation electric field, which allows the electric field separation and electrospray ionization of the sample to be accomplished simultaneously, thereby improving the sensitivity of detection.

Abstract: A method for analyzing ionic structure, including: applying a radio frequency electric field on an ion mass analyzer to cause sample ions to be excited to a motion amplitude, the motion amplitude at this moment being recorded as a primary motion amplitude; continuously feeding carrier gas into the ion mass analyzer and keeping a certain degree of vacuum in the ion mass analyzer, the sample ions being collided with the carrier gas and the motion amplitude being decreased gradually, and collecting a time domain signal of an image current generated by the sample ions during the process; and analyzing the time domain signal through a time-frequency analysis method and obtaining time-varying characteristic curves indicating corresponding relations between the motion frequencies of the ions having corresponding sizes and the collision cross sectional areas of the ions and the carrier gas, thus distinguishing among ions having different sizes.

Abstract: An ion trap-based device and method for analyzing and detecting bipolar ions is provided. The device includes multiple electrodes of an ion trap; a radio frequency voltage source configured to form a radio frequency electric field; a direct current voltage source configured to form a bias electric field, positive and negative ions in the ion trap being separated by the bias electric field; a first and second detectors, configured to detect the positive and negative ions, respectively. A bipole and quadrupole field direct current voltage detection modes may be employed. A single positive ion or negative ion operation mode in a conventional biological mass spectrometry method is improved, so that the positive and negative ion modes are performed simultaneously; without any resolution loss, the analysis speed is increased, the sample consumption is reduced, and the accuracy of quantitative analysis of the samples is improved.

Abstract: An ion trap-based device and method for analyzing and detecting bipolar ions is provided. The device includes multiple electrodes of an ion trap; a radio frequency voltage source configured to form a radio frequency electric field; a direct current voltage source configured to form a bias electric field, positive and negative ions in the ion trap being separated by the bias electric field; a first and second detectors, configured to detect the positive and negative ions, respectively. A bipole and quadrupole field direct current voltage detection modes may be employed. A single positive ion or negative ion operation mode in a conventional biological mass spectrometry method is improved, so that the positive and negative ion modes are performed simultaneously; without any resolution loss, the analysis speed is increased, the sample consumption is reduced, and the accuracy of quantitative analysis of the samples is improved.