Patents by Inventor Mwlod Ghareeb

Mwlod Ghareeb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for the measurement of tacrolimus in oral fluids by liquid chromatography tandem mass spectrometry
    Patent number: 10126316
    Abstract: Disclosed is a method of measuring tacrolimus levels in a subject. In exemplary embodiments, the method comprises the steps of: collecting oral fluid from the subject; homogenizing the oral fluid; combining the homogenized oral fluid with a precipitating solvent; separating oral fluid components on a liquid chromatography column by gradient elution with a mixture of a solvent A and a solvent B, wherein the solvent A is about 2 mM ammonium acetate/0.1% (v/v) formic acid in water and solvent B is about 2 mM ammonium acetate/0.1% (v/v) formic acid in MeOH and wherein the amount of solvent B is increased from about 50% (v/v) to about 98% (v/v); and quantifying the amount of tacrolimus in the oral fluid by mass spectrometry.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: November 13, 2018
    Assignee: Rhode Island Council on Postsecondary Education, Statutory Sucessor to the Rhode Island Board of Education, and Rhode Island Board of Governors for Higher Education
    Inventors: Fatemeh Akhlaghi, Mwlod Ghareeb
  • Systems and Methods for the Measurement of Tacrolimus in Oral Fluids by Liquid Chromatography Tandem Mass Spectrometry
    Publication number: 20170276693
    Abstract: Disclosed is a method of measuring tacrolimus levels in a subject. In exemplary embodiments, the method comprises the steps of: collecting oral fluid from the subject; homogenizing the oral fluid; combining the homogenized oral fluid with a precipitating solvent; separating oral fluid components on a liquid chromatography column by gradient elution with a mixture of a solvent A and a solvent B, wherein the solvent A is about 2 mM ammonium acetate/0.1% (v/v) formic acid in water and solvent B is about 2 mM ammonium acetate/0.1% (v/v) formic acid in MeOH and wherein the amount of solvent B is increased from about 50% (v/v) to about 98% (v/v); and determining amount of tacrolimus in the oral fluid by mass spectrometry.
    Type: Application
    Filed: March 22, 2017
    Publication date: September 28, 2017
    Inventors: Fatemeh Akhlaghi, Mwlod Ghareeb