Abstract: A method of reducing or preventing bubbles in a microfluidic sample liquid is provided. The method comprises providing a microfluidic sample holder comprising an enclosed fluid channel for holding at least part of the sample liquid, and filling at least part of the fluid channel with a sample liquid. The method further comprises: a step of pressurizing the sample liquid in the fluid channel to raise a sample liquid pressure to an elevated pressure higher than an ambient pressure and an operating pressure, a step of maintaining the sample liquid pressure at least at the elevated pressure for a predetermined period to cause dissolving of gas into the sample liquid, and a step of reducing the sample liquid pressure from the elevated pressure to the operating pressure. An associated system is also provided.

Abstract: A pressure sensing clip (1) and a system including a bandage (19) for detecting and displaying the pressure applied by a (compression) bandage (19) to a human or animal body in which the pressure sensing clip (1) has an inner bandage penetrating arm (2) and an outer arm (3) hingedly attached to the inner arm (2) at a hinge (4) so that the outer arm (3) is movable between a hingedly closed position with respect to the inner arm (2) and a hingedly open position. The device can be operatively attached to an applied compression bandage, or it can be placed beneath or between the bandage during bandage application so that the bandage covers the sensing part of the device. In the latter application, the ability of the arms of the device to adapt an open configuration allows the bandage to be applied over the inner arm leaving the outer arm to close once the bandage has been applied. The device can receive, store and transmit data to a user.