Patents by Inventor Myriam-Laure Cubizolles
Myriam-Laure Cubizolles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11442055Abstract: The invention relates to a method for detecting an analyte present in a liquid specimen, including: injecting the liquid specimen into a detection chamber, the detection chamber having a non-zero volume enclosing polymeric beads covered with a reagent suitable for the analyte to be detected; capturing at least one image of at least one region of the detection chamber using a sensor; processing the image acquired by the sensor, which includes determining a texture level of the acquired image; and determining a concentration of the analyte depending on the texture level determined for the image.Type: GrantFiled: July 17, 2020Date of Patent: September 13, 2022Assignee: Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Myriam-Laure Cubizolles, Thomas Bordy, Frederic Revol-Cavalier
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Patent number: 11391652Abstract: A system for preparing a calibrated volume of blood plasma that includes a plurality of parts: a device for preparing the calibrated volume of blood plasma, which is in the form of a single card; a pneumatic-type actuating system SP; a treatment and command unit UC configured such as to execute a command sequence of different pneumatic command points of the pneumatic actuation system with a view to obtaining, from a taken blood sample, the calibrated volume of blood plasma. The device includes three distinct modules: a fluidic connection module M1 onto which a blood sampling device may be connected; a module M2 for separation of the blood plasma contained in the blood sample; a module M3 for obtaining at least one calibrated volume of blood plasma, after separation.Type: GrantFiled: November 14, 2019Date of Patent: July 19, 2022Assignee: Commissariat A L'Energie Atomique et aux Energies AlternativesInventors: Myriam-Laure Cubizolles, Manuel Alessio, Remco Den Dulk, Frederic Revol-Cavalier
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Publication number: 20220081706Abstract: A method for detecting target biological species in a biological sample, the method being implemented in a device that makes it possible to concatenate the preparation of a sample for a detection via selective capture and a detection via biomolecular amplification.Type: ApplicationFiled: September 10, 2021Publication date: March 17, 2022Applicant: Commissariat à l'Energie Atomique et aux Energies AlternativesInventors: Myriam-Laure CUBIZOLLES, Anne-Gaëlle BOURDAT, Maud SAVONNET
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Publication number: 20210018488Abstract: The invention relates to a method for detecting an analyte present in a liquid specimen, characterized in that it comprises steps of: injecting said liquid specimen into a detection chamber (23), said detection chamber (23) having a non-zero volume enclosing polymeric beads (25) covered with a reagent suitable for said analyte to be detected, capturing at least one image of at least one region of the detection chamber using a sensor (30), processing said image acquired by the sensor, this comprising determining a texture level of said acquired image, and determining a concentration of said analyte depending on the texture level determined for said image.Type: ApplicationFiled: July 17, 2020Publication date: January 21, 2021Applicant: Commissariat a I'Energie Atomique et aux Energies AlternativesInventors: Myriam-Laure CUBIZOLLES, Thomas BORDY, Frederic REVOL-CAVALIER
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Publication number: 20200158604Abstract: A system for preparing a calibrated volume of blood plasma that includes a plurality of parts: a device for preparing the calibrated volume of blood plasma, which is in the form of a single card; a pneumatic-type actuating system SP; a treatment and command unit UC configured such as to execute a command sequence of different pneumatic command points of the pneumatic actuation system with a view to obtaining, from a taken blood sample, the calibrated volume of blood plasma. The device includes three distinct modules: a fluidic connection module M1 onto which a blood sampling device may be connected; a module M2 for separation of the blood plasma contained in the blood sample; a module M3 for obtaining at least one calibrated volume of blood plasma, after separation.Type: ApplicationFiled: November 14, 2019Publication date: May 21, 2020Applicant: Commissariat A L'Energie Atomique et aux Energies AlternativesInventors: Myriam-Laure Cubizolles, Manuel Alessio, Remco Den Dulk, Frederic Revol-Cavalier
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Patent number: 10407711Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: GrantFiled: December 18, 2018Date of Patent: September 10, 2019Assignee: bioMérieuxInventors: Marie-Hélène Charles, Jean-Philippe Charrier, Myriam-Laure Cubizolles, Agnès Dupont-Filliard, Véronique Lanet, Florence Rivera, Laurent Veron, Lucie Baujard-Lamotte, Christine Peponnet
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Patent number: 10346983Abstract: The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood.Type: GrantFiled: July 10, 2018Date of Patent: July 9, 2019Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AU ENERGIES ALTERNATIVES, AVALUNInventors: Jean-Guillaume Coutard, Patrick Pouteau, Myriam Laure Cubizolles
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Publication number: 20190112632Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: ApplicationFiled: December 18, 2018Publication date: April 18, 2019Applicants: bioMérieux, Commissariat à l'Energie Atomique et aux Energies AlternativesInventors: Marie-Hélène CHARLES, Jean-Philippe CHARRIER, Myriam-Laure CUBIZOLLES, Agnès DUPONT-FILLIARD, Véronique LANET, Florence RIVERA, Laurent VERON, Lucie BAUJARD-LAMOTTE, Christine PEPONNET
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Patent number: 10190148Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: GrantFiled: May 2, 2013Date of Patent: January 29, 2019Assignees: bioMérieux, Commissariat à l'Energie Atomique et aux Energies AlternativesInventors: Marie-Hélène Charles, Jean-Philippe Charrier, Myriam-Laure Cubizolles, Agnès Dupont-Filliard, Véronique Lanet, Florence Rivera, Laurent Veron, Lucie Baujard-Lamotte, Christine Peponnet
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Publication number: 20190012788Abstract: The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood.Type: ApplicationFiled: July 10, 2018Publication date: January 10, 2019Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, AVALUNInventors: Jean-Guillaume COUTARD, Patrick POUTEAU, Myriam Laure CUBIZOLLES
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Patent number: 10126315Abstract: The method is provided for characterizing agglomeration of particles in a liquid containing an analyte, including introducing liquid into a fluid chamber; mixing the liquid with a bifunctional reagent, lighting the fluid chamber using an excitation light beam extending through the fluid chamber in a longitudinal direction (X); acquiring at least one image using a matrix photodetector, each image including pixels (In(x,y), x,y representing the coordinates of a pixel of an image, the image (I(x,y)) being formed by radiation transmitted by the lighted fluid chamber; and calculating from at least one acquired image (I(x,y)), at least one indicator (Ind2) characterizing the particle agglomeration. The photodetector can be positioned less than 1 cm from the fluid chamber, and during the calculation step, the calculated indicator (Ind2) is representative of the intensity of the pixels of the image. The method advantageously allows for characterizing the agglomeration of particles in a liquid.Type: GrantFiled: April 8, 2016Date of Patent: November 13, 2018Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVESInventors: Vincent Poher, Myriam-Laure Cubizolles, Patrick Pouteau, Cédric Allier, Johanna Spiaczka
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Patent number: 10049453Abstract: The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood.Type: GrantFiled: July 7, 2016Date of Patent: August 14, 2018Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, AVALUNInventors: Jean-Guillaume Coutard, Patrick Pouteau, Myriam Laure Cubizolles
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Patent number: 9921147Abstract: The invention is a method for characterizing a liquid sample, said liquid sample containing particles, the method comprising the following steps: a) illuminating said sample using a light source that is able to emit an incident light wave towards the sample; b) detecting, using a photodetector, a light wave transmitted by the sample thus illuminated; c) characterizing the sample depending on an intensity of the light wave detected by the photodetector. The method comprises, prior to step c), applying an acoustic wave to the sample, said acoustic wave forming pressure nodes and pressure antinodes in the sample, so as to separate, in the latter, a poor portion, poor in particles, and rich portion, rich in particles, such that, in step c), the sample is characterized: either on the basis of the intensity of the light wave transmitted by the poor portion; or on the basis of the intensity of the light wave transmitted by the rich portion.Type: GrantFiled: March 16, 2017Date of Patent: March 20, 2018Assignee: Commissariat A L'Energie Atomique et aux Energies AlternativesInventors: Vivian Aubert, Myriam-Laure Cubizolles, Cedric Poulain, Maxime Huet, David Rabaud
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Publication number: 20170268989Abstract: The invention is a method for characterizing a liquid sample, said liquid sample containing particles, the method comprising the following steps: a) illuminating said sample using a light source that is able to emit an incident light wave towards the sample; b) detecting, using a photodetector, a light wave transmitted by the sample thus illuminated; c) characterizing the sample depending on an intensity of the light wave detected by the photodetector. The method comprises, prior to step c), applying an acoustic wave to the sample, said acoustic wave forming pressure nodes and pressure antinodes in the sample, so as to separate, in the latter, a poor portion, poor in particles, and rich portion, rich in particles, such that, in step c), the sample is characterized: either on the basis of the intensity of the light wave transmitted by the poor portion; or on the basis of the intensity of the light wave transmitted by the rich portion.Type: ApplicationFiled: March 16, 2017Publication date: September 21, 2017Applicant: Commissariat A L'Energie Atomique et aux Energies AlternativesInventors: Vivian AUBERT, Myriam-Laure CUBIZOLLES, Cedric POULAIN, Maxime HUET, David RABAUD
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Publication number: 20170011517Abstract: The invention is a method for estimating the amount of analyte in a fluid sample, and in particular in a bodily fluid. The sample is mixed with a reagent able to form a color indicator in the presence of the analyte. The sample is then illuminated by a light beam produced by a light source; an image sensor forms an image of the beam transmitted by the sample, from which image a concentration of the analyte in the fluid is estimated. The method is intended to be implemented in compact analyzing systems. One targeted application is the determination of the glucose concentration in blood.Type: ApplicationFiled: July 7, 2016Publication date: January 12, 2017Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, AVALUNInventors: Jean-Guillaume COUTARD, Patrick POUTEAU, Myriam Laure CUBIZOLLES
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Patent number: 9506935Abstract: This method for estimating the quantity of an analyte contained in a liquid includes the following steps: introducing the liquid into a fluid chamber; mixing the liquid with a bi-specific reagent, the bi-specific reagent being configured for grafting on both a particle and an analyte present in the liquid; lighting the fluid chamber using an excitation beam emitted by a light source, the beam extending through the fluid chamber; acquiring at least one image using a matrix photodetector, the image being formed by radiation transmitted by the lighted fluid chamber; and estimating, from at least one acquired image, the quantity of said analyte in the liquid.Type: GrantFiled: December 4, 2014Date of Patent: November 29, 2016Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVESInventors: Maxime Huet, Vincent Poher, Myriam-Laure Cubizolles, Patrick Pouteau, Cédric Allier, Johanna Spiaczka
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Publication number: 20160299158Abstract: The method is provided for characterizing agglomeration of particles in a liquid containing an analyte, including introducing liquid into a fluid chamber; mixing the liquid with a bifunctional reagent, lighting the fluid chamber using an excitation light beam extending through the fluid chamber in a longitudinal direction (X); acquiring at least one image using a matrix photodetector, each image including pixels (In(x,y), x,y representing the coordinates of a pixel of an image, the image (I(x,y)) being formed by radiation transmitted by the lighted fluid chamber; and calculating from at least one acquired image (I(x,y)), at least one indicator (Ind2) characterizing the particle agglomeration. The photodetector can be positioned less than 1 cm from the fluid chamber, and during the calculation step, the calculated indicator (Ind2) is representative of the intensity of the pixels of the image. The method advantageously allows for charactering the agglomeration of particles in a liquid.Type: ApplicationFiled: April 8, 2016Publication date: October 13, 2016Inventors: Vincent POHER, Myriam-Laure CUBIZOLLES, Patrick POUTEAU, Cédric ALLIER, Johanna SPIACZKA
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Patent number: 9341636Abstract: The method according to the invention is capable of characterizing a variation in the speed of particles or agglomeration of particles, the particles, such as blood particles, being contained in a liquid (12). The characterization method includes the following steps: introducing the liquid (12) into a fluid chamber (14); lighting the fluid chamber (14) using an excitation light beam (18) emitted by a light source (16), the light beam (18) extending through the fluid chamber (14) in a longitudinal direction (X); acquiring at least one image using a matrix photodetector (20), the image being formed by radiation transmitted by the lighted fluid chamber (14); and calculating, from at least one acquired image, at least one indicator characterizing the variation of the speed or agglomeration of the particles. During the acquisition step, the photodetector (20) is positioned at a distance (D2) smaller than 1 cm from the fluid chamber (14) in the longitudinal direction (X).Type: GrantFiled: May 30, 2013Date of Patent: May 17, 2016Assignee: Commissariat à l'énergie atomique et aux énergies alternativesInventors: Vincent Poher, Myriam-Laure Cubizolles, Patrick Pouteau, Cédric Allier, Johanna Spiaczka
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Publication number: 20150160244Abstract: This method for estimating the quantity of an analyte contained in a liquid includes the following steps: introducing the liquid into a fluid chamber; mixing the liquid with a bi-specific reagent, the bi-specific reagent being configured for grafting on both a particle and an analyte present in the liquid; lighting the fluid chamber using an excitation beam emitted by a light source, the beam extending through the fluid chamber; acquiring at least one image using a matrix photodetector, the image being formed by radiation transmitted by the lighted fluid chamber; and estimating, from at least one acquired image, the quantity of said analyte in the liquid.Type: ApplicationFiled: December 4, 2014Publication date: June 11, 2015Inventors: Maxime HUET, Vincet Poher, Myriam-Laure Cubizolles, Patrick Pouteau, Cédric Allier, Johanna Spiaczka
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Publication number: 20150087003Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: ApplicationFiled: May 2, 2013Publication date: March 26, 2015Applicants: bioMérieux, Commissariat à I'Energie Atomique et aux Energies AlternativesInventors: Marie-Hélène Charles, Jean-Philippe Charrier, Myriam-Laure Cubizolles, Agnès Dupont-Filliard, Véronique Lanet, Florence Rivera, Laurent Veron