Abstract: A device for removing and replacing a protective cover on a needle of a hypodermic syringe. The device includes a base member having a generally planar bottom surface together with means for securing the bottom surface to an external flat surface. A tubular member extends from the base member at a predetermined angle relative to the planar bottom surface. The tubular member includes an open end for receiving axially a needle with a protective cover and an inner surface defining an elongated cylindrical cavity having an inner diameter sligthly larger than the maximum diameter of the protective cover to be received therein. Tab means extending inwardly from the inner surface of the tubular member are provided to operably engage a lip on the protective cover when the cover is within the cavity. The lip is operable to engage at the tab means when the protective cover is urged thereagainst whereby the protective cover remains within the tubular member while needle is removed therefrom.