Patents by Inventor Myron R. Melamed

Myron R. Melamed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of halogenated precursors incorporated into DNA
    Patent number: 5747258
    Abstract: A method for detecting halogenated precursors incorporated into DNA is presented. The method is based on the selective photolysis of DNA by ultraviolet (UV) light at the sites of an incorporated halogenated precursor, such as the thymidine base analogs 5-bromo-2-deoxyuridine (BrdUrd), 5-iodo-2-deoxyuridine (IdUrd), 5-fluoro-2-deoxyuridine (FdUrd), or 5-chloro-2-deoxyuridine (CldUrd). The 3'-hydroxyl termini of the DNA single strand breaks generated during photolysis may be marked directly or indirectly with a fluorescent label. The DNA termini are directly labeled with fluorochrome-conjugated deoxyuridine triphosphate (dUTP) catalyzed by exogenous terminal deoxynucleotidyl transferase or DNA polymerase (nick translation system). The DNA termini are indirectly labeled with either biotin- or digoxygenin-conjugated dUTP; the incorporated biotin or digoxygenin is then detected following binding of fluorochrome-conjugated avidin or anti-digoxygenin antibody, respectively.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: May 5, 1998
    Assignee: New York Medical College
    Inventors: Zbigniew D. Darzynkiewicz, Xun Li, Frank N. Traganos, Myron R. Melamed
  • Cell-surface glycoproteins of human sarcomas
    Patent number: 5059523
    Abstract: This invention provides a method of identifying mesenchymal tissues as normal, proliferatively active or malignant. This invention also provides a method of distinguishing subsets of sarcomas with distinctive antigenic phenotypes. This invention also provides a method of diagnosing mesenchymal tumors. Finally, this invention provides a monoclonal antibody designated G171 and the hybridoma cell line producing said monoclonal antibody (ATCC No. HB9254).
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: October 22, 1991
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Wolfgang J. Rettig, Pilar Garin-Chesa, H. Richard Beresford, Herbert F. Oettgen, Myron R. Melamed, Lloyd J. Old
  • Method for characterizing types of renal carcinoma and prognosis
    Patent number: 4935344
    Abstract: Antigenic profiles of renal carcinoma specimans developed with panels of monoclonal antibodies derived from several different tissues serve as useful clinical indicators for cancer type, cancer subset as well as histiogenesis and prognosis indicators.
    Type: Grant
    Filed: March 7, 1986
    Date of Patent: June 19, 1990
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Neil H. Bander, Carlos Cordon-Cardo, Connie L. Finstad, Willet F. Whitmore, Myron R. Melamed, Herbert F. Oettgen, Lloyd J. Old
  • Monoclonal antibodies to human lung cancers and method
    Patent number: 4865998
    Abstract: A panel of monoclonal antibodies produced from normal human lung fibroblasts and human lung tumors as immunogen is used to diagnose the presence of lung tumors and differentiate between those which are benign and those which are cancerous.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: September 12, 1989
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Hans-Joachim Feickert, Wolfgang Rettig, Karen Chorney, Carlos Cordon-Cardo, Myron R. Melamed, Kenneth O. Lloyd, Herbert F. Oettgen, Lloyd J. Old, Bernd Anger
  • Monoclonal antibodies to human bladder and ureter cancers and method
    Patent number: 4643971
    Abstract: A panel of monoclonal antibodies, produced from human bladder tumors as immunogen, is used to diagnose the presence of transitional cell carcinoma in patients. The panel is also used to identify and differentiate low grade non-invasive papillomas from invasive life-threatening transitional cell carcinomas, thereby enabling decisions as to the extent of bladder surgery. These mAbs can also be used as a panel for tissue typing of normal and abnormal cell specimens.
    Type: Grant
    Filed: December 30, 1983
    Date of Patent: February 17, 1987
    Assignee: Sloan-Kettering Institute
    Inventors: Yves Fradet, Carlos Cordon-Cardo, Willet F. Whitemore, Jr., Myron R. Melamed, Lloyd J. Old, Kenneth O. Lloyd
  • Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies
    Patent number: 4579827
    Abstract: A panel of monoclonal antibodies produced from human gastrointestinal tumors as immunogen is used to diagnose the presence of colon cancer. The antibody panel subsets the human gastrointestinal tract in its reactivity vis-a-vis esophagus, stomach, small intestine and colon. The panel is useful as a diagnostic probe for cancer.
    Type: Grant
    Filed: March 11, 1983
    Date of Patent: April 1, 1986
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Junichi Sakamoto, Carlos Cordon-Cardo, Eileen Friedman, Connie L. Finstad, Warren E. Enker, Myron R. Melamed, Kenneth O. Lloyd, Herbert F. Oettgen, Lloyd J. Old