Patents by Inventor Myron Spector
Myron Spector has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230000762Abstract: The present disclosure presents hydrogel compositions for use in the treatment of an ocular disorder (e.g., a retinal disease) and methods of treating an ocular disorder in a subject in need thereof with the hydrogel compositions. The hydrogel compositions can include hydroxyphenylpropionic acid (gelatin-HPA), hyaluronic acid-tyramine (HA-Tyr), a catalyzer (e.g., horseradish peroxidase (HRP)), a cell, a crosslinker (e.g., hydrogen peroxide), or any combination thereof. The methods include administering a therapeutically effective amount of a composition into an eye of the subject, wherein the composition includes any of the hydrogel compositions of the disclosure.Type: ApplicationFiled: December 3, 2020Publication date: January 5, 2023Inventors: Pierre A. Colombe, Deepti Singh, Myron Spector, Michael Young
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Publication number: 20140094809Abstract: A method of creating a penetration with reduced sidewall compaction in a surface of a bone or articular joint. The method includes the steps of positioning a surgical instrument in contact with the surface, applying a longitudinal force to the surgical instrument causing the surgical instrument to penetrate the surface thereby creating a penetration with at least one sidewall, and retracting the surgical instrument and strategically scraping a portion of the surgical instrument against a portion of the at least one sidewall to remove compacted material from the penetration, thereby creating a small surgically created wound in the surface having reduced compaction at the margins to promote rapid vascular penetration, cellular migration, and faster healing with an enhanced histologically confirmed maturing tissue. The surgical defect can be round or slit-like.Type: ApplicationFiled: December 4, 2013Publication date: April 3, 2014Inventors: Lanny L. Johnson, Myron Spector
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Publication number: 20140094806Abstract: A surgical instrument whose cutting portion is a sharp miniature chisel or awl shape with a series of ridges along the course of the cutting tool. Each ridge has, on its proximal surface, a concave surface. Upon retraction, the instrument is pushed against the side of the defect, allowing the compacted bone on the walls to be captured in the concave recesses of the instrument. Existing instruments compact bone against the walls of the surgical defect rather than removing the compacted bone or tissue. The creation of a small surgically created wound in subchondral bone, absent the thickened compacted bone at the margins, responds with rapid vascular penetration and cellular migration and faster healing with an enhanced histologically confirmed maturing tissue. The surgical defect can be round or slit-like. The instrument allows a wide spectrum of angle of attack to create the surgical defect in the bone and/or articular surface.Type: ApplicationFiled: October 2, 2012Publication date: April 3, 2014Inventors: Lanny Leo Johnson, Myron Spector
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Patent number: 8084428Abstract: A method of repairing a meniscal tear of a subject includes providing a sheet of collagen membrane material having on one side thereof a smooth barrier face which inhibits cell adhesion thereon and inhibits passage of cells therethrough. The sheet has a fibrous face opposite the smooth barrier face, the fibrous face allowing cell growth thereon. The collagen is predominantly collagen I. The sheet of collagen membrane material is fixed over a meniscal tear so that the fibrous face is oriented toward the meniscal tear.Type: GrantFiled: September 1, 2006Date of Patent: December 27, 2011Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Myron Spector, Peter Geistlich, Lothar Schloesser, Roland Jakob, Jean-Francois Clemence
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Publication number: 20100291173Abstract: A method of improving renal function in a mammal suffering from, or at risk of developing, at least partial renal failure or renal dysfunction, includes administering to renal tissue of the mammal, a combination comprising a non-viral vector comprising a non-viral particulate carrier which carries a therapeutically effective amount of genetic material capable of expressing a renal function-enhancing Osteogenic Protein-1/Bone Morphogenic Protein-7 (OP-1/BMP-7) polypeptide in the renal tissue.Type: ApplicationFiled: September 4, 2007Publication date: November 18, 2010Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Myron Spector, Peter Geistlich
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Publication number: 20090186062Abstract: A method of repairing a meniscal tear of a subject includes providing a sheet of collagen membrane material having on one side thereof a smooth barrier face which inhibits cell adhesion thereon and inhibits passage of cells therethrough. The sheet has a fibrous face opposite the smooth barrier face, the fibrous face allowing cell growth thereon. The collagen is predominantly collagen I. The sheet of collagen membrane material is fixed over a meniscal tear so that the fibrous face is oriented toward the meniscal tear.Type: ApplicationFiled: September 1, 2006Publication date: July 23, 2009Applicant: ED. GEISTLICH SOEHNE AG FUER CHEMISCHE INDUSTRIEInventors: Myron Spector, Peter Geistlich, Lothar Schloesser, Roland Jakob, Jean-Francois Clemence
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Publication number: 20060121609Abstract: This invention relates to gradient scaffolds, methods of producing the same, and methods of use thereof, in particular for applications in tissue engineering, repair and regeneration. The gradient scaffolding includes, inter-alia, scaffolds, which are varied in terms of their pore diameter, chemical composition, crosslink density, or combinations thereof, throughout the scaffolding.Type: ApplicationFiled: September 21, 2005Publication date: June 8, 2006Inventors: Ioannis Yannas, Lorna Gibson, Fergal O'Brien, Brendan Harley, Ricardo Brau, Stephen Samouhos, Myron Spector
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Publication number: 20040170664Abstract: Injured nerves are reconnected and regenerated by inserting injured nerve ends into a collagen tube having an outer compact smooth barrier surface preventing ingrowth of connective tissue, avoiding formation of scar tissue and allowing for unimpaired healing of injured nerves. The tube has an inner fibrous surface opposite the outer smooth barrier surface. The soft fibrous inner surface of the tube facilitates nerve growth promotion.Type: ApplicationFiled: March 10, 2004Publication date: September 2, 2004Applicant: Ed. Geistlich Soehne AGInventors: Myron Spector, Lothar Schloesser, Peter Geistlich
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Patent number: 6710025Abstract: The present invention is directed to therapeutic methods that are based upon an ability to modulate cellular contraction. This is accomplished by administering agents that either inhibit or induce the activity of alpha-smooth muscle actin.Type: GrantFiled: May 23, 2000Date of Patent: March 23, 2004Assignee: The Brigham and Women's Hospital, Inc.Inventor: Myron Spector
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Patent number: 6676969Abstract: A resorbable extracelluar matrix for reconstruction of cartilage tissue includes a purified collagen II derived from natural cartilage tissue from which non-collagen proteins have been removed.Type: GrantFiled: November 9, 2001Date of Patent: January 13, 2004Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Myron Spector, Zdenek Eckmayer
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Publication number: 20020048595Abstract: A resorbable extracelluar matrix for reconstruction of cartilage tissue includes a purified collagen II derived from natural cartilage tissue from which non-collagen proteins have been removed.Type: ApplicationFiled: November 9, 2001Publication date: April 25, 2002Inventors: Peter Geistlich, Myron Spector, Zdenek Eckmayer
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Patent number: 6352558Abstract: A method of promoting regeneration of surface cartilage of a joint includes the steps of forming punctures in a subchondral plate of an area of the joint to be treated, covering the puncture and the area to be treated with a chondrocyte-free patch made of a sheet of collagen membrane material without adding chondrocytes to the area to be treated, fixing the patch over the area to be treated, and allowing the area to be treated to regenerate cartilage without adding chondrocytes to the area to be treated.Type: GrantFiled: December 29, 1999Date of Patent: March 5, 2002Assignee: Ed. Geistlich Soehne AG fuer Chemische IndustrieInventor: Myron Spector
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Publication number: 20020018799Abstract: Injured nerves are reconnected and regenerated by inserting injured nerve ends into a collagen tube having an outer compact smooth barrier surface preventing ingrowth of connective tissue, avoiding formation of scar tissue and allowing for unimpaired healing of injured nerves. The tube has an inner fibrous surface opposite the outer smooth barrier surface. The soft fibrous inner surface of the tube facilitates nerve growth promotion.Type: ApplicationFiled: June 21, 2001Publication date: February 14, 2002Inventors: Myron Spector, Lothar Schloesser, Peter Geistlich
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Patent number: 6326029Abstract: A resorbable extracellular matrix for reconstruction of cartilage tissue, the matrix being substantially free from non-native collagen, and including a purified collagen II material formed form natural cartilage and having fibers of native collagen II which are physiologically acceptable for implant into a mammalian body.Type: GrantFiled: November 10, 1997Date of Patent: December 4, 2001Assignee: Ed Geistlich Soehne AG fuer Chemische IndustrieInventors: Peter Geistlich, Myron Spector, Zdenek Eckmayer
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Patent number: 6034296Abstract: An implantable self-powered sensing system for a bone fixation device, which includes a self-powered strain sensor mountable on or in a bone fixation device, is disclosed. The sensor is capable of measuring strain in the bone fixation device by generating a strain signal in response to stresses produced thereupon. The system also includes a telemetry unit powered by the generated strain signal and in communication with the sensor. The telemetry unit is activated by the sensor when the strain signal reaches a predetermined value and then transmits the strain signal from the sensor to an external receiver. The sensing system can also include a buffer unit in communication with the sensor and the telemetry unit for collecting and storing the strain signals for transmission by the telemetry unit as a cumulative strain measurement.Type: GrantFiled: December 4, 1997Date of Patent: March 7, 2000Inventors: Niell Elvin, Alex Elvin, Myron Spector
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Patent number: 4882149Abstract: Pharmaceutical depot preparation for implantation into base tissue comprising natural bone mineral from which the naturally associated fat and bone-proteins have been removed whereby said bone is sterile and non-allergenic, said bone mineral having absorbed thereon and/or adsorbed therein one or more physiologically active substances. The physiologically active substance is advantageously an antibiotic or taurolidine or tauraltam or a protein or polypeptide assisting bone regeneration.Type: GrantFiled: September 21, 1988Date of Patent: November 21, 1989Assignee: Ed. Geistlich Sohne A.G. fur Chemische IndustrieInventor: Myron Spector
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Patent number: 4773406Abstract: A bone fracture fixation device for fixation to a fractured bone is substantially free from resorbable materials and materials which soften on exposure to body fluids, and undergoes a gradual decrease in rigidity over the healing period of the fracture.Type: GrantFiled: July 2, 1987Date of Patent: September 27, 1988Assignee: Ed. Geistlich Sohne AG fur Chemische IndustrieInventors: Myron Spector, John D. Muzzy
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Patent number: 4756862Abstract: Prosthetic devices, such as orthopedic, dental and maxillofacial prostheses, are provided which are composed of an inner load bearing, functional component and an outer foamed or sintered porous coating of selected bioengineering thermoplastics. The bioengineering thermoplastic coating is provided in regions where long-term bone fixation is desired by tissue ingrowth. The coatings offer substantial biomechanical advantages over any material system previously reported. Also provided, are anatomically shaped devices comprised totally of bioengineering thermoplastics with select porous areas; these devices include bone gap bridges, bone caps, and alveolar ridge augmentation implants.Type: GrantFiled: June 23, 1986Date of Patent: July 12, 1988Assignee: Amoco CorporationInventors: Myron Spector, George T. Kwiatkowski, Walter H. Smarook, Michael J. Michno, Jr.
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Patent number: 4362681Abstract: Prosthetic devices, such as orthopedic, dental and maxillofacial prostheses, are provided which are composed of an inner load bearing, functional component and an outer foamed or sintered porous coating of selected bioengineering thermoplastics. The bioengineering thermoplastic coating is provided in regions where long-term bone fixation is desired by tissue ingrowth. The coatings offer substantial biomechanical advantages over any material system previously reported. Also provided, are anatomically shaped devices comprised totally of bioengineering thermoplastics with select porous areas; these devices include bone gap bridges, bone caps, and alveolar ridge augmentation implants.Type: GrantFiled: January 18, 1980Date of Patent: December 7, 1982Assignee: Union Carbide CorporationInventors: Myron Spector, George T. Kwiatkowski, Walter H. Smarook, Michael J. Michno, Jr.
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Patent number: 4164794Abstract: Prosthetic devices, such as orthopedic, dental and maxillofacial prostheses, are provided which are composed of an inner load bearing, functional component and an outer foamed or sintered porous coating of selected bioengineering thermoplastics. The bioengineering thermoplastic coating is provided in regions where long-term bone fixation is desired by tissue ingrowth. The coatings offer substantial biomechanical advantages over any material system previously reported. Also provided, are anatomically shaped devices comprised totally of bioengineering thermoplastics with select porous areas; these devices include bone gap bridges, bone caps, and alveolar ridge augmentation implants.Type: GrantFiled: April 14, 1977Date of Patent: August 21, 1979Assignee: Union Carbide CorporationInventors: Myron Spector, George T. Kwiatkowski, Walter H. Smarock, Michael J. Michno, Jr.